High TSH, T4 within range : Hi, I’m a 23 year old... - Thyroid UK

Thyroid UK

126,353 members148,229 posts

High TSH, T4 within range

LPS1 profile image


I’m a 23 year old female and went to see my doctor yesterday regarding my underactive thyroid. I’ve been on levothyroxine for around 2 years now and am on a dosage of 75mg. I was shown history of my test results and each time my dose had been increased, my TSH would rise quite significantly. Surely this must mean the medication isn’t working if my TSH continues to increase? It is currently at 10.6 when it should be between 0.27-4.20 in the UK. My T4 is within range at 13.7 (should be between 12.00-22.00). My doctor suggested I raise the dosage of my medication again but I’m feeling hesitant. I also suffer from digestive issues and feel since being on the medication I’ve become quite anxious too.

Has anyone had any similar experiences or could give me some advice? Thanks

12 Replies
SlowDragon profile image

75mcg is only one step up from starter dose of 50mcg

The aim of Levothyroxine is to increase the dose slowly in 25mcg steps upwards until TSH is under 2 (many need TSH significantly under one) and most important is that FT4 in top third of range and FT3 at least half way in range

So your doctor is correct to say you need 25mcg dose increase in Levothyroxine

Anxiety is common hypothyroid symptom

NHS guidelines on Levothyroxine including that most patients eventually need somewhere between 100mcg and 200mcg Levothyroxine.


Bloods should be retested 6-8 weeks after each dose increase

For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested. Also important to test vitamin D, folate, ferritin and B12

Low vitamin levels are extremely common, especially if Thyroid antibodies are raised

If vitamins and antibodies have not been tested, request they are

Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and fasting. This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip, best not mentioned to GP or phlebotomist)

Last Levothyroxine dose should be 24 hours prior to test, (taking delayed dose immediately after blood draw).

Private tests are available. Thousands on here forced to do this as NHS often refuses to test FT3 or antibodies or all vitamins


Medichecks Thyroid plus ultra vitamin or Blue Horizon Thyroid plus eleven are the most popular choice. DIY finger prick test or option to pay extra for private blood draw. Both companies often have special offers, Medichecks usually have offers on Thursdays, Blue Horizon its more random

If antibodies are high this is Hashimoto's, (also known by medics here in UK more commonly as autoimmune thyroid disease).

About 90% of all primary hypothyroidism in Uk is due to Hashimoto's.

Low vitamins are especially common with Hashimoto's. Food intolerances are very common too, especially gluten. So it's important to get TPO and TG thyroid antibodies tested at least once .

Link about thyroid blood tests


Link about antibodies and Hashimoto's



List of hypothyroid symptoms


All four vitamins need to be regularly tested and frequently need supplementing to maintain optimal levels

Gut issues are extremely common with Hashimoto's. Gluten free diet can often help significantly

Hashimoto's frequently affects the gut and leads to low stomach acid and then low vitamin levels

Low vitamin levels affect Thyroid hormone

Poor gut function can lead leaky gut (literally holes in gut wall) this can cause food intolerances. Most common by far is gluten. Dairy is second most common.

According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps, sometimes significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Changing to a strictly gluten free diet may help reduce symptoms, help gut heal and slowly lower TPO antibodies

While still eating high gluten diet ask GP for coeliac blood test first or buy test online for under £20, just to rule it out first

Assuming test is negative you can immediately go on strictly gluten free diet

(If test is positive you will need to remain on high gluten diet until endoscopy, maximum 6 weeks wait officially)

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse







Levothyroxine should always be taken on empty stomach and then nothing apart from water for at least an hour after

Many people take Levothyroxine soon after waking, but it may be more convenient and more effective taken at bedtime

All medication at least two hours away from Levo. Some like HRT, PPI's, magnesium, iron or vitamin D, at least four hours away


Many people find Levothyroxine brands are not interchangeable.

Once you find a brand that suits you, best to make sure to only get that one at each prescription. Watch out for brand change when dose is increased or at repeat prescription.

Many patients do NOT get on well with Teva brand of Levothyroxine. Though it is the only one for lactose intolerant patients. Teva is the only brand that makes 75mcg tablet.

LPS1 profile image
LPS1 in reply to SlowDragon

Thank you for your advice. I’m on a gluten free and lactose free diet - I’ve had a full thyroid panel done privately along with vitamin levels and they were all in the normal range. It’s just the TSH that is elevated and keeps on increasing regardless of the dose. I do think the levothyroxine plays a part in irritating my stomach though which is why I don’t particularly want to increase.

SlowDragon profile image
SlowDragonAdministrator in reply to LPS1

If you are dairy free you will need Teva brand of Levothyroxine. Or, if Teva upsets you, then liquid Levothyroxine is possible, but it's expensive and likely need to see an endocrinologist to get prescribed

Your results clearly show you are under medicated and hypothyroid

Official NHS guidelines saying TSH should be between 0.2 and 2.0 when on Levothyroxine

(Many of us need TSH nearer 0.2 than 2.0 to feel well)

See box

Thyroxine replacement in primary hypothyroidism


Vitamin levels need to be optimal, not just within range

Vitamin D at least around 80nmol and around 100nmol may be better

Folate at least over ten

Serum B12 at least over 500

Active B12 at least over 70

Ferritin at least half way in range

shaws profile image

It seems to me, very obvious, that your doctor is another who doesn't know very much about the thyroid gland and its functions.

Like the majority of members on this forum, we have read and learn how best we, the patient, can improve by reading/asking questions and following advice.

The aim, once we're diagnosed as hypothyroid, is a TSH of 1 or lower and a Free T4 and Free T3 towards the upper part of the ranges.

When you give numbers, always quote the ranges as labs differ in their machines and so do the ranges.

The aim once we begin levothyroxine is to have a TSH of 1 or lower with both FT4 and FT3 in the upper part of the ranges. The aim is that we feel we have 'normal' health and can do everything we used to without effort.

Insist on an increase of 25mcg now and in six weeks get another test and so on every six weeks until your TSH is 1 or lower - not 'somewhere in the ranges' as most doctors seem to think

All blood draw should be at the very earliest, (make appointment well in advance). It should also be a fasting test (you can drink water) and allow a gap of 24 hours between last dose of levo and test and take afterwards.

The aim is a TSH of 1 or lower with both Frees (T4/T3) in the upper part of the ranges.

Vitamin B12, Vit D, iron, ferritin and folate have also to be optimum.

Everything in our body is affected by hypothyroidism and (I am not medically qualified) believe if you gradually increase your dose by 25mcg every six weeks that you will begin to feel a lot better, i.e. your digestion too. If everything in our body slows down due to insufficient hormone replacement, we will feel unwell, we will also have symptoms we didn't have before.

Always get a print-out of your results with the ranges. Also ask for B12, Vit D, iron, ferritin and folate to be checked. These also must be optimum and others will suggest how to improve them if they are also low. Symptoms will also occur if our dose is too low and this is a list.


All should disappear when our dose is optimum. Optimum means we feel well with no symptoms despite the numbers on the blood test results.

shaws profile image

This is a list of symptoms which should be relieved once on an optimum dose that suits us.


LPS1 profile image
LPS1 in reply to shaws

Thanks I appreciate your help

If your TSH is rising despite increases in dose - not that you've had many increases - it rather sounds like you aren't absorbing it. How do you take your levo? Do you take it on an empty stomach and wait at least an hour before eating or drinking anything other than water? Do you take any other medication/supplements at the same time as your levo?

LPS1 profile image
LPS1 in reply to greygoose

I was taking it first thing in the morning on an empty stomach. I now take it just before I go to bed on an empty stomach just to see if that makes any difference

greygoose profile image
greygoose in reply to LPS1

OK, that's good. :)

But, you still don't seem to be absorbing. Do you have low stomach acid? Have you had vit D, vit B12, folate and ferritin tested?

SlowDragon profile image
SlowDragonAdministrator in reply to LPS1

Hundreds of posts on here about low stomach acid and how to improve absorption

LPS1 profile image
LPS1 in reply to SlowDragon

Thank you

Thanks Slow Dragon and others for replies.

Especially the point about wanting TSH under 2 or even under 1, when levothyroxine dose is correct.

LPS1, and any other younger women reading - the “normal” range max of 4.2 is definitely not what you want if you are planning a family or having fertility problems.

For women pre-conception, the max was 2.5, back in 2015, when I had unfortunate reason to find out. My GP was not aware.

I can’t find the TSH guideline range (normal or pre-conception) in the NICE guidelines just now... if anyone knows of one, please post.

(Mine has gone up to 4 (from very low) in the last year, which GP is unconcerned about :-0

Not sure i feel different! Have gone gluten-free the last 9months, hoped to feel loads better but TPO abs are worse.

Due to talk to GP again, so will check the links above and go armed with info.)

You may also like...