Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population

[helvella]

It appears there is the start of a probable avalanche of genetic information about thyroid disorders. This paper identifies four SNPs associated with Graves Disease but not, it seems, Hashimoto's.

(I don't think we have much of a grasp on whether this being a Chinese population has any impact on interpretation for non-Chinese. For now, I'd be tempted to assume no difference.)

Front Endocrinol (Lausanne). 2019 Jan 16;9:811. doi: 10.3389/fendo.2018.00811. eCollection 2018.

Variations in CD14 Gene Are Associated With Autoimmune Thyroid Diseases in the Chinese Population.

Jia X1, Wang B1, Yao Q1, Li Q1, Zhang J2.

Author information

1 Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai, China.

2 Department of Endocrinology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Abstract

Autoimmune thyroid diseases (AITDs) are chronic organ-specific autoimmune diseases and mainly include Graves' disease (GD) and Hashimoto's thyroiditis (HT). CD14 is an important component of the immune system as a receptor for gram-negative lipopolysaccharide (LPS). The genetic polymorphisms of CD14 have been confirmed to be associated with a variety of autoimmune diseases. However, its relationship with AITDs is still unclear. The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT. The results showed significant association of rs2915863 and rs2569190 with GD. The frequencies of rs2915863 genotypes and T allele in patients with GD differed significantly from their controls (P = 0.007 and P = 0.021, respectively). For rs2569190, frequencies of genotypes and G allele in GD patients also showed positive P-values (P = 0.038 and P = 0.027, respectively). The correlations between these two loci and GD are more pronounced in female GD patients and patients with a family history. In genetic model analysis, the allele model, recessive model, and homozygous model of rs2569190 and rs2915863 embodied strong correlations with GD after the adjusting of age and gender (P = 0.014, P = 0.015, P = 0.009, and P = 0.014, P = 0.001, P = 0.006, respectively). However, these four sites are not related to HT. We firstly discovered the relationship between CD14 gene polymorphism and GD, and the results indicate that CD14 is an important risk locus for AITD and its SNPs may contribute to host's genetic predisposition to GD.

KEYWORDS:

CD14; Graves' disease; Hashimoto's thyroiditis; autoimmune thyroid diseases; single nucleotide polymorphisms

PMID: 30700980

PMCID: PMC6343429

DOI: 10.3389/fendo.2018.00811

ncbi.nlm.nih.gov/pubmed/307...

Full paper freely available here:

ncbi.nlm.nih.gov/pmc/articl...

The Wiki article provides a basic introduction as to what a single-nucleotide polymorphism (SNP) is and why it can be important:

en.wikipedia.org/wiki/Singl...

[sarosent]

I have an account with Selfdecode.com to try and figure out my genetics, and I seem to have many Genes/SNP's pointing to a risk of Grave's disease even though I'm hypothyroid; these studies also refer to Chinese or Japanese population. CD14 didn't show up for me, however.

Helvella, do you have any experience with Selfdecode? I seem to often hit a dead-end. Maybe it's just too complex for me.

I sure hope there will be an avalanche of more studies of thyroid disease.

I do wonder how Pubmed defines Graves disease, or Hypothyroidism for that matter - based on T3, or just on TSH?