Levothyroxine and antihistamines: Please can... - Thyroid UK

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Levothyroxine and antihistamines

StillEverHopeful profile image

Please can anyone advise me if it is ok to take antihistamines with Levo?

Suddenly I am having trouble getting my regular anti depressant (clomipramine 10mgx3) in a make that is not Teva (it causes itching).. I have phoned around loads of chemists and they all say they can only get teva and to take it with antihistamines to sort out the horrible itching.(as an aside I do wonder if my longstanding depression/anxiety were symptoms of poor thyroid function)

I'm not happy about it but feel I don't have any choice. The last few months the awful thyroid fatigue has started to lift and I am doing a bit more 'normal' and am anxious that if the GP changes my Anti depressant or I add antihistamines that I will suffer a setback.

I'm so grateful for you all on this forum.

7 Replies
shaws profile image

Take the anti-histamine one hour before levo. You should be o.k.

Re your anti-depressant? Has your doctor checked both your Frees? i.e. FT4 and FT3. If T3 is too low that could be the cause of 'depression' but I doubt doctors are aware of this.

These are two links:



I’ve just realised I haven’t thanked you shaws.

I decided to stop the antidepressant under active thyroid has probably been a big part of my depression, so now my Frees are finally in upper half of range I’ve stopped taking them. Have had some withdrawal symptoms (a bit snappy ) but also had a stinker of a cold for nearly two weeks.

shaws profile image
shawsAdministrator in reply to StillEverHopeful

No thanks are necessary :)

If we've been on other medications, sometimes a gradual reduction rather than 'cold turkey' might be better. FT3 is a good test but not done on the NHS (if you are in the UK) but the fact that you feel better is good.

I managed to get my GP to do T3 after a medichecks test said it was boarder line low in range 😀 and I’m in the UK 🇬🇧. I was also referred to an Endo who I have a review with in a few weeks and she has included in t3 bloods again.

I was on the lowest dose possible for the antidepressant & hadn’t stopped before as I didn’t want to alter too many things at once, so not too much cold turkey rather just not being able to choose when.

shaws profile image
shawsAdministrator in reply to StillEverHopeful

Yes I think you're doing the correct thing. Good luck that your appointment goes well.

Mentalhealthdaily/levothyroxine adverse reactions..

We have to take a stand against shite t4 brands and the toxicity there causing.

Masking the side effects with ...belive me in the past 7 years I've had most psychiatric medications..

Penny dropped ,Good luck on your Mission 🚀x

StillEverHopeful profile image
StillEverHopeful in reply to

I have a note on my levo and a specific antidepressant prescription saying “not Teva” the chemist can provide levo in another make but the antidepressant there is a supply issue and currently only in Teva. I have now stopped the antidepressant and waiting for withdrawal symptoms to pass... but I also have cold/cough which could be reason for some symptoms. Hoping once cold passes all withdrawal symptoms will too.

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