In summary, thyroid peroxidase (TPO) antibodies are the most common type of thyroid antibody. Although they are more strongly associated with Hashimoto’s, 80% of those with Graves’ disease will have elevated TPO antibodies. As for what causes elevated TPO antibodies, according to the triad of autoimmunity someone needs to have a genetic predisposition, exposure to an environmental trigger, and a leaky gut in order to develop autoimmunity, and thus elevated autoantibodies. As a result, in order to decrease TPO antibodies you need to find and remove the autoimmune trigger, heal the gut, and you might also need to do other things to reduce proinflammatory cytokines and increase glutathione levels.
TPO Antibodies in Hashimoto’s and Graves’ Disea... - Thyroid UK
TPO Antibodies in Hashimoto’s and Graves’ Disease by Dr Eric Osansky
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