Not getting on with block and replace

[437jd]

I'm 6months in to my Graves treatment and over the last 9 weeks, since starting on levothyroxine for block and replace, I have had hyper symptoms; tremors, palpitations and my key sign- a strange vibration in my groin near my main artery- which laughed at by the medical profession. Yet deep down once this strange sensation occurs I know my levels are high. So, I was on 100mcg levo and 40mg carb up until 3 weeks ago and these symptoms flared up. Had my bloods which show over the range so the endo reduced me to 75mcg levo. Took this for 5 days and the symptoms continued. So I took the executive decision to reduce levo to 50 mcg. For a week I felt great! I had energy for the first time in months. This week the symptoms started again. Yesterday is was To the point that my tremors were visible and I took propanalol just to stop the palpitations. Today I haven't taken any levo just the carb and while I know levo builds up over time why do I feel an instant change? No tremors, steady pulse, no vibration.... can somebody please offer any advice......

[Nanaedake]

I don't know anything about Graves disease but have you tried a different formulation of levothyroxine to see if it makes a difference? What type are you taking there are several formulations available in the UK.

[437jd in reply to Nanaedake]

Thanks yes it might be the brand. I've taken it today just to see what happens......

[bantam12]

It may be that B&R just doesn't suit you, never worked for me.

[437jd in reply to bantam12]

Did you do tritation instead?

[bantam12 in reply to 437jd]

My Graves journey was a long one with a relapse many years after partial surgery, went back onto Carb then B&R which didn't work so I asked for RAI as I was fed up with the constant messing about with meds and doses.

[437jd in reply to bantam12]

There's no quick fix is there? Thyroid meds are just trial and error! Hope you're ok now.

[bantam12 in reply to 437jd]

There is no quick fix with either hyper or hypo but for me hypo is far easier to live with.

[Hypo88]

If I were you I'd be taking carbimazole only

[437jd in reply to Hypo88]

Thanks for replying. I'm scared I'll go hypo if I just take carbimazole. Feel like it's a catch 22 scenario!

[Clutter in reply to 437jd]

437jd,

You will need to reduce Carbimazole dose if you stop taking Levothyroxine and will need regular thyroid tests to check you are titrating the right amount of Carbimazole.

[437jd in reply to Clutter]

Thanks Clutter. I'll bare that in mind. I'm going to call my endos secretary and see if I can speak to him or at least arrange an earlier appointment or blood test.