So once again, TSH high. 572.20. t3 1.5 Synthyroid 300mcg daily. Armour 60mg daily. Nothing seems to work. Is it possible for your body to reject the meds after taking for over 46 yrs, Can you become immune to meds?. When hospitalized and injected thru veins the levels start to climb down.
off the chain tsh level: So once again, TSH high... - Thyroid UK
off the chain tsh level


You have posted before and, oddly, have never responded to previous replies. So as a result little is still known about of your overall health background. Have you had nutrients tested? Ferritin, folate, VitD and b12 are important levels to get results on as they effect conversion. Have you ever gone GF? Do you have your labs done after fasting, first thing in the morning and having no dosage for 24 hours? Do you take dosage on an empty stomach at least 1 hour before eating? I can't answer the question about immunity, but with so many questions remaining unanswered it will be difficult for anyone to weigh in with useful feedback.

In addition to Rusty's questions, do you take supplements containing biotin?
The theory of rejection seems highly unlikely, given that these are not drugs, but hormones. 300 mcg Synthroid is a high dose, but if you can't convert it, you might just as well take nothing. However, we cannot possibly know how well you convert without comprehensive results and ranges : FT4 and FT3. I cannot, for the life of me, see the point of adding in just one grain of NDT! That is 9 mcg T3! How is that supposed to help? Have you ever tried T3 only? That would seem the next logical step. But, if you don't talk to us, we'll never know, will we?

That TSH result is a duff result if ever I saw one. Get another TSH by a different test method.
Denise630,
1. Possible Lab error, retest sample or send it to a different lab with different analysis machinery.
2. Possibly heterophile antibodies to TSH interfering with the assay. Send samples to a different lab for testing, one which uses different machinery.
3. If you take biotin supplements or biotin in B Complex and the lab uses biotin in the assay it will skew results. Stop biotin or B Complex a day or two before blood tests.