I have been diagnosed with Grave's Disease. Consultant has been controlling it since last November with Carbimazole. At last consultation he said that they had increased/decreased dosage several times and had not got levels under control so he wanted to move to block and replace. After about 5 weeks I seem to have every thyroid symptom going all at once so have stopped block and replace and immediately felt better. Have gradually improved over a few days although still not right so am trying some carbimazole to see if that works. Despite consultants concern, mostly with carbimazole I have been OK if not perfect. Has anyone else had problems with block and replace and any idea what could be wrong?