Does anybody know if there are factors that can effect how T3 gets taken up in the cells.
I just more then doubled my dose of T3 but i had to drop it down a little because my pulse was hitting 90 plus but yet no movement on my temps. And no change in my symptoms.
Probably of absolutely no practical use whatsoever. That's assuming any of us can make more than a tiny bit of sense of yet another fiendishly complicated bit of management of thyroid hormone in the human body.
thyroidmanager.org/chapter/...
Always remember that adjustment to a dose of thyroid hormone can take a long time to have the desired effect. It is a bit concerning that you have made what sounds like such a large adjustment to your dose.
Doubling your dose sounds extreme, especially in light of no lab results, and no info on your current dose to support such an increase. We always have dosage increases done gradually, in increments and in multi-week intervals - no charging ahead here! For us to make more educated choices in our care it requires current lab results, and careful overview of our nutrient levels. Without this information there can be no accurate conversation about your treatment plan.
Whoa - slow down a bit you guys. No assumptions please. But yeah I suppose I over condensed my story.
Went from 50 to 100 T3 over a period of a few months based on blood test results and my doctors advice.
My main question- are there essential nutrients that are necessary for getting T3 into cells. Or other health conditions that impact T3.
I've had hashis since 2003, yet I've never felt any major improvement on T3. Lately it seems I've reach a new low. No motivation for much of anything. Weight gain, loss of appetite, hair loss, depression, mood swings, etc...
Absolutely there are essential nutrients.
Thorough lab results can show us our levels of Ferritin, folate, B12 and D3. These form the key ones we tend to be deficient in due to malabsorption issues/gut problems common in thyroid disease. (This is one of the reasons it is often recommended we try adapting a gluten free diet as it can reduce inflammation levels). Many of us have bloodwork done via private labs in order to obtain all this information as they are not commonly tested. (even free T3 is often not tested!
The thyroid UK site has a helpful link to a few of these:
thyroiduk.org.uk/tuk/testin...
And an excellent post for any newbie looking for very good info on those nutrients follows:
This conversion needs a sequence of minerals, vitamins and cofactors to work and can be blocked by other seemingly disconnected Primary causes such as low stomach acid and leaky gut or heavy metal build up. Another important consideration is that the deiodinase enzyme DIO2 iwhich removes the Iodine from T4 to make active T3 within every cell might be genetically compromised. If so you have a DIO2 polymorphism ensure that your bio unique system can be supported to be the best it can be.
Key ingredients can be found on the Thyroid UK website. I've been focusing on methylation pathways, binding heavy metals, supporting mitochondria.. Anything to remove the intracellular toxic load.
I'm using an infra red sauna regularly as I discovered after testing that the rubbish needs to be removed before the T3 can do it magic. Magnesium has been really important for me as my metabolism improved. Epson salt baths and magnesium gel/oil has been a godsend.
Test don't guess and if possible use the guidance of a functional nutritionist. Pm me if you want a reference.
Best Wishes
Mourneadventurer
Do you have the Dl02 polymorphism Mourneadventurer? I know I have it along with others affecting thyroid hormone absorption and it's caused me no end of trouble.
Everything that you're saying about DIO2 polymorphism has to do with converting T4 to T3. I am extremely T4 intolerant i can only take T3. So a DIO2 polymorphism would not apply...or?
Im not concerned with conversion. What gets the T3 into cells? When I took T4 my health deteriorated so severly i was rushed to the hospital. I was a close call. Right now I feel like falling down the same rabbit hole. My hair is now falling out, no appetite yet weight gain, depression, I'm withdrawing from life. Why isn't my T3 working?
Yes unfortunately I am heterozygous. However I'm glad I've discovered this along with methylation issues. This probably underlies everything else.
Vitamin B's are crucial.
Best Wishes
Mourneadventurer
Adding t3 into the mix?
NHS endocrine clinics that prescribe T3 Liothyronine
Research into getting T3 meds 
T3
Cutting T3 tablets into quarters success. 
