Hi, I was diagnosed hypothyroid (hashimoto's) at Easter. I have rheumatoid arthritis, which is well controlled by humira injections (fortnightly). I went gluten free three years ago and also avoid some other foods. Problem is, I felt fantastic when I started on 50 mcg levothyroxin, but that faded after a couple of weeks. Each dose increase has helped for a short while and then symptoms have returned. I'm now on 100 mcg and haven't noticed any improvement, in fact I felt worse, depressed and tearful all the time. I persuaded GP to let me take an extra 25 mcg alternate days but after my latest blood test they have phoned to say go back to 100 mcg. I feel so tired and have poor memory and can't think straight. Is anyone else on humira for RA? I know it's hard to get, I was lucky to be put in a trial 16 years ago, it worked, and I was allowed to continue on it. Maybe these ups and downs are normal? I would just like to get back the joy and energy I felt when I first started on levothyroxin. Such a shame it didn't last!