It is good that you are trying to assist your wife in her illness. You are not the first husband to have the worry because they know their wives so well and want to understand but doctors/endos have no interest in solving the problem. Which should be easy when on the correct thyroid hormones for that patient.
The GPs hands are tied because the guidelines state that T4 (levothyroxine) only is to be prescribed. GPs who say, if the person is hypo, that symptoms are nothing to do with the illness are completely unknowledgeable about how our metabolism is fed with proper hormones and T3 is king.
I am assuming your wife has been diagnosed with hypothyroidism and given levothyroxine. (probably too low a dose) and has recurring symptoms which are being diagnosed as 'something other than thyroid' which is rubbish of course.
I was far more unwell when, finally, given levothyroxine that it was a complete mystery why!
Through Thyroiduk.org.uk (no HU then) and I found my way through to goodhealth.
I have also paid for Private consultations and I should have saved my money. Some members have had good Endos but they appear to be few and far between.
If you email email@example.com and ask for her list of recommended doctors. You can then select a couple and put up a new post with their names and ask for information to be sent to you by private message. No info is allowed on the forum without the expresss permission of the doctors especially if they 'think outside the box'.
When your wife has a blood test for thyroid hormones it should be as early as possible and don't eat before it although you can drink water. If on thyroid hormones allow 24 hours between the last dose and the test and take levo afterwards. This keeps the TSH at its highest and may prevent the GP adjusting hormones unnecessarily so.
The doctors don't have to live with very unwell people due to the stupid regulations which state the blood tests alone are the diagnosis not the symptoms (they don't know any clinical symptoms but treat with another medication rather than a decent dose of thyroid hormones). The addition of T3 is often very helpful. I am fit and well on T3 only now and was also good on NDT (natural Dessicated Thyroid Hormones which contain all of the hormones a healthy gland would produce) instead they assume that most of us can convert levo (T4) to sufficient T3 (the only active hormone required in our receptor cells). Some people also have a gene defect and that result means that they cannot convert T4 whatsoever but doubt any doctor has heard of that.
If your GP hasn't tested Free T4 and Free T3 you can have these tested through a recommended lab and I'll give details:
Get a print-out of the results with the ranges and post for comments We can get well and I am one of those but it was a journey but successful in the end.
This is an archived link and there are other topics at the top of the page but the info is good. Dr Lowe died of an accident but was very humane for the suffering we undergo and unnecessarily so for many.