Some are nervous about taking T3 but I am sure you will feel much better. I, personally, have always taken dose once daily as it is more convenient (I do know many split but tablets are made to be taken once). If you are nervous, it's right to drop down to 75mcg levo but I'd take half a T3 tablet to begin with (then increase by half after 2 weeks -or quarter if you prefer). Always take note of your pulse and temp several times a day before you begin and afterwards, i.e too fast or high, drop back to previous dose. T3 I think you are aware is the active hormone and it is T3 only which is needed in our receptor cells, its work then begins and lasts between 1 to 3 days.
Two links may be helpful:-
Excerpt from link below:-
These clinical and experimental findings argue against that idea of "cycling" enabling patients to maintain improvement after stopping their use of T3. With increases and decreases in dosage, the only thing that has cycled in our patients is their fibromyalgia status. So, do I believe that "cycling" will "cure" cellular resistance to thyroid hormone? Unequivocally, no!
Third, the leaflet on Cytomel pharmacies give patients when they fill their prescriptions states, "POSSIBLE SIDE EFFECTS: NO COMMON SIDE EFFECTS HAVE BEEN REPORTED with proper use of this medication." This information is accurate—when plain, full-strength, one-time-per-day doses of T3 are used properly, there are no adverse effects. The only adverse effects occur when a patient takes a dosage that for her is excessive. With Cytomel, if overstimulation occurs, it can be stopped with one or two small doses of propranolol. Or the patient can simply reduce her dosage of Cytomel the next time she takes it. I want to emphasize, however, that when our protocol is used properly, there is no overstimulation to be avoided by using timed-release T3. The protocol has safeguards against adverse effects. And finally, why do I specify that the typical patient use one full dose of non-timed-release Cytomel for life? Because extensive testing has shown that this is safe, effective, and most economical—when used within the context of our entire protocol.
The above doctor was also a scientist and logician who also took one daily dose of T3 (150mcg). Dr. Lowe is a devout critical rationalist and before his death was an Adviser to Thyroiduk.org.uk.
I am not medically qualified - only have my own experience and am well now.