Thyroid UK

"We discovered a small amino acid sequence - we call it p10 because it is 10 amino acids long -- within the TSH receptor protein," Schöneberg explains. This sequence "functions as activator of the receptor upon binding of the hormone or autoantibodies."

In other words, the receptor itself flips the switch -- when it should and when it shouldn't.

CREDIT

Journal of Biological Chemistry (doi: 10.1074/jbc.M115.701102)