Can't seem to tolerate NDT

This is the third time I've endeavoured to switch to NDT from 20yrs on synthetic (thyroxine in Australia ) I actually feel worse on NDT , i can go for about 7 days before it all starts to slide downhill with spun out feelings, palpitations and sleeplessness. I've started on a dose of half grain am and half grain pm. I seriously think I do better on synthetic only ( no problems with it, just wondered what all the fuss is about with NDT ) does anybody else have the same problem?

17 Replies

  • I couldn't tolerate NDT, either, and I tried for years! I put on so much weight, totally out of control although I hardly had any appetite. I'm better off on synthetic T3 only.

    But it's like everything else : great for some people, not so good for others, because we're all different. And we waste our lives trying to force ourselves into the same little box as everyone else. Take what suits you best, that's my advice, and Don't worry about what other people do. :)

  • Totally agree !

  • Jmariabrunt, how much Levothyroxine were you taking? 1 grain NDT is bioactively equivalent to 75-100mcg Levothyroxine.

  • 200mg thyroxine for 20 yrs have tried NDT 3 times over past 18months this time is the longest I've ever gone (10days) but feeling dreadful started on one grain per day raised yesterdY to 1.5 but had to tKe to my bed !

  • Jmariabrunt, if you'd reduced thyroxine as you introduced and raised NDT you'd have spared yourself a hypo period. If you're tolerating 1.5 grains ok raise to 2 grains after a week and then to 2.5 grains two weeks later.


    I am not a medical professional and this information is not intended to be a substitute for medical guidance from your own doctor. Please check with your personal physician before applying any of these suggestions.

  • My endo ( and sttm) protocol said to stop thyroxine one day and start NDT the next ! Feeling so awful today on second day of raising to 1.5 grains it's so tempting to stop !

  • Jmariabrunt, the protocol's fine if you are able to switch from an equivalent Levothyroxine dose to equivalent NDT dose but you're bound to become hypothyroid when you stop 200mcg Levothyroxine and replace it with 1 grain which is equivalent to only 75-100mcg. At this stage it must be hard to determine whether you are hypothyroid, not tolerating NDT, or both.

  • Which brand? Some suit people more than others... All brands of ndt are not the same.

  • Pharmacy compounded

  • I also was so anxious to try NDT and was sadly disappointed. Now I take Levoxyl and Cytomel and I'm doing much better.

  • Jmariabrunt, clearly, as Clutter has pointed out, you aren't supplementing the right amount of NDT but I don't think you've given it enough time either. Personally I think it can take a while for the body to get used to the T3 and I had to do this very slowly in baby baby steps, or you might be better on a combination of NDT and synthetic to give a more accurate ratio of T4 to T3 in humans.

  • Didn't think you could mix synthetic and NDT ?

  • I do personally and it works well for me. I take 100mcg T4 and 1 grain NDT. The NDT gives me the T3 element as my T3 level was low.

  • If you are well on synthetic T4 be very very grateful indeed

    Theres 6 Hashimotos in my family between husband , daughter and 4 granddaughters

    the only one who is well on synthetic thyroxine is our other daughters little girl

    The rest suffer excrutiating joint pains on either Thyroxine or T3 and have no option but to take NDT

  • Now I don't know what to do , continue on NDT and hope things improve or go back to thyroxine where I didn't ever really have any problems !

  • it does take time and being on the right dosage and being with a dr that doesn't pay much attention to tsh to feel right on ndt. many drs still look at tsh and keep the dose too low...and don't test ft3.....but for me it takes PATIENCE........BEC it does take the body a while to get used to getting t3 and balance out all the systems in the body.....But on a nother note...many article written that state that people with adrenal fatigue will have problems on ndt.......or they will never feel optimal on t4 with still having hypo symptoms......vitamin c and b vitamins important to adrenals....sleeping 8 hours, and staying off sugar and caffeine.....

  • I changed from Armour, to Nature Thyroid both NDT, what a difference feel great on Nature Thyroid, it must be the different fillers they use. Like a lot of others I felt terrible on Thyroxine.

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