Recently I have had some unpleasant episodes of missed heart beats. I Had tests over a year ago which confirmed I did have these episodes but all was okay. I was given Bisoprolol as an as and when option (changed from propranolol) and due to stressful times ended up taking half a 1.25 tablet everyday. When I tried to stop the above episodes started and now am getting them a few times daily. The doctor told me to change to 2.5. But my heart rate is quite low and in my last thyroid blood test my TSH was 9. I've upped my levothyroxine accordingly. What I was wondering was is it possible that due to low TSH and bisoprolol lowering heart rate that my heart is having to work too hard as they are almost working against each other and that I should really try to come off bisoprolol. I have another doctor's appointment booked. I just wondered if anyone had this problem. I almost feel the bisoprolol is having the opposite effect to what it should. Thanks.