A couple of abstracts of possible interest. The second I have posted before, but there have been many thousands of posts and new members since last time.
World J Gastroenterol. 2009 Jun 21; 15(23): 2834–2838.
Published online 2009 Jun 21. doi: 10.3748/wjg.15.2834
Consequences of dysthyroidism on the digestive tract and viscera
Ronald Daher, Thierry Yazbeck, Joe Bou Jaoude, and Bassam Abboud
Thyroid hormones define basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and deficiency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo- and hyperthyroidism. Specific digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto’s thyroiditis and Grave’s disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to confirm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations.
Keywords: Hypothyroidism, Hyperthyroidism, Gastrointestinal motility, Intestine, Liver, Viscera
Full paper available here:
Klin Med (Mosk). 2006;84(2):71-4.
[Hiatus hernia and gastroesophageal reflux disease as a manifestation of a newly revealed hypothyroidism].
[Article in Russian]
Savina LV, Semenikhina TM, Korochanskaia NV, Klitinskaia IS, Iakovenko MS.
The aim of the study was to reveal hypothyroidism (HT) in patients with hiatus hernia (HH), treated at Russian Centre of Functional Surgical Gastroenterology. The subjects were 64 women: 18--with HH and diffuse or diffuse nodular goiter, 36--with HH, and 10--without endocrine or somatic disease background. The examination included the evaluation of the thyroid and metabolic status, endoscopy, and 24-hour ph-metry. The results show that one of the early signs of HT is HH and gastroesophageal reflux disease. The latter in HT patients is associated with gastrointestinal motor-evacuatory disturbances rather than with acid exposition in the distal esophagus.
PMID: 16613012 [PubMed - indexed for MEDLINE]
Abstract only available here: