Thyroid UK
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Does B12 supplementation require an increase in folate too?

I'm thinking about supplementing with straight, high-dose sublingual B12. But I remember reading that B12 and folate need to be balanced: does this mean that if I supplement with B12 I should also supplement with folic acid too?

My last B12 test came back at 477 pmol/l (197-?) and my serum folate was just under the bottom of the normal range (can't remember what the value was, sorry).

2 Replies

Hose, as your folate is deficient your GP should have prescribed folic acid 5mg. You can probably get 4mg folic acid OTC and self supplement or get methylfolate. The FA PIL recommends 4 months supplementation but my folate was good after 4 weeks x 5mg and my prescription stopped. I continued supplementing B12 without folic acid.

ps it's a good idea to take a B complex too to keep the 'B's balanced.


I am sure you know that the B12 should, preferably, be methylcobalamin. This is a link for info:-


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