I just came across this statement on a website. As these are my main concerns how do I tell if the T3 is unsteady or just not enough? I have been taking T3 now for 6 weeks and am now taking 45 mcg at 9/12/4pm but am considering taking it all at once. When I first started I was taking 15 mcg sustained release four times per day and noticed more of a change with this. Any thoughts? I have read that SR is not as good. Really not sure what to do. Main concern is facial puffiness and pain. Considering taking the dose all at once to see if improvement occurs as per Dr Lowe.