Yes, we're hoping for a good outcome, having worked hard to submit as soon as we could. Essentially the study shows that no overarching reference range for TSH exists. It is affected by age, weight, size of the active gland, and most important, T4 therapy but not the sex of the subject and only marginally by smoking habit. This is also different in pregnancy, though we have not studied this condition here - a clinical trial is being planned to address this in more detail. There are however many papers showing the effects of pregnancy on TSH etc. Using an overarching TSH range means that it is set too wide, and false negatives can arise, because some people can be within the wide range but outside the narrower range specific for their situation. The relation between FT4, FT3 and TSH and the setting of reference ranges is for all parameters conditional ie based on the individual's particular physiological and genetic characteristics. Nothing is set in stone and therefore a return has to be made to carefully considering patient presentation and using tests as either confirmatory or suggesting further examination, but not as dictates in a statistical sense of the word. If and when we get the new paper published, we are going to try to depict the fluid situation pictorially but this won't start until May earliest.