I am not medically qualified but will say I think your dose of 25mcg is still too small, unless you are very frail. If you cursor to the question dated June 8, 2001 to read the answer. You may have to copy and paste the link as I don't think they work yet with this new system.
This is an extract from Pulse Online by Dr Toft ex of the BTA:-
6 What is the correct dose of thyroxine and is there any rationale for adding in tri-iodothyronine?
The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range – 0.2-0.5mU/l.
In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l. Most patients will feel well in that circumstance.
But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l.
I cannot link to the following but for your information I have copied this re PCOS:-
Multiple Ovarian Cysts as
a Major Symptom of Hypothyroidism
The case I describe below is of importance to women with polycystic ovaries. If
they have evidence, such as a high TSH, that conventional clinicians accept as evidence
of hypothyroidism, they may fair well. But the TSH is not a valid gauge of a woman's
tissue thyroid status. Because of this, she may fair best by adopting self-directed
care. At any rate, for women with ovarian cysts, this case is one of extreme importance.
In 2008, doctors at the gynecology department in Gunma, Japan reported the case
of a 21-year-old women with primary hypothyroidism. Her doctor referred her to the
gynecology department because she had abdominal pain and her abdomen was distended
up to the level of her navel.
At the gynecology clinic she underwent an abdominal ultrasound and CT scan. These
imaging procedures showed multiple cysts on both her right and her left ovary.
The woman's cholesterol level and liver function were increased. She also had a
high level of the muscle enzyme (creatine phosphokinase) that's often high in hypothyroidism.
Blood testing also showed that the woman had primary hypothyroidism from autoimmune
It is noteworthy that the young woman's ovarian cysts completely disappeared soon
after she began thyroid hormone therapy. Other researchers have reported girls with
primary hypothyroidism whose main health problems were ovarian cysts or precocious
puberty. But this appears to be the first case in which a young adult female had
ovarian cysts that resulted from autoimmune-induced hypothyroidism.
The researchers cautioned clinicians: "To avoid inadvertent surgery to remove an
ovarian tumor, it is essential that a patient with multiple ovarian cysts and hypothyroidism
be properly managed, as the simple replacement of a thyroid hormone could resolve
the ovarian cysts."
1. Kubota, K., Itho, M., Kishi, H., et al.: Primary hypothyroidism presenting as
multiple ovarian cysts in an adult woman: a case report. Gynecol. Endocrinol.,