I was diagnosed in 2007 with our 'little problem!' I've just had my bloods done and the TSH has risen from 0.09 to over 0.3 and T4 - I don't know if it was the free variety or not - has gone from 19 to over 20. My problem is, I also have IBS and have to take merbeverine first thing in the morning 20 minutes before food. Now you can see my dilema!! When should I take my thyroxin so that it has the maximum effect and not be troubled by taking it with other meds? I tried taking it at night but woke up the next day feeling decidedly 'off balance' - I also take betahistine for an inner ear problem and beta blockers for migraine! I know - I'm falling to bits!! I would be grateful for any advice. Thanks very much bloggers.