Triphala update

[Mutleyforever]

Unfortunately I have had to ( temporarily I hope ) stop Triphala. I had been experiencing venous pain behind my left knee for a couple of weeks, it affected me badly when walking and even if I rested. Initially I did not connect the two, but since I had stopped everything else, I had to stop it to see if that was the culprit…….It was, anyway I have decided to concentrate on upping my acid levels, to help my digestion with apple cider vinegar twice a day, and so far, so good.

[Meleber]

It's always trial and error when looking for something that could help to alleviate our symptoms. Good to know that you probably did find the cause of the pain but unfortunately for you it seems to be related to Triphala. Cascara Sagrada or senna could also be options to try, if you haven't tried them before already. I've had good experiences with cascara in the past for alleviating my IBS C symptoms. Now on a trial with prucalopride and using a mix of bisacodyl / triphala / cascara as additional laxatives in the startup phase. My bowels didn't react 'immediately' and that's why I need to take 'rescue' medication too. My trial with prucalopride is for a month so will end the 1st of December.

PS Maybe you could find a Ayurvedic practitioner to ask why you had an adverse reaction 🤔

[Mutleyforever in reply to Meleber]

Thanks Meleber, my slow transit does not need treatment now, I don’t need to take any medication but know that I am still dysfunctional, with visceral pain etc. I’m pretty sure I have low stomach acid that is behind all this ( quite common due to ageing and stress) , and also a trigger for ibs but completely overlooked by medics. Anyway I’m back on Apple cider vinegar, and maybe herbal bitters, ….see how that goes 😊

[Meleber in reply to Meleber]

Research

Source: "Potential Inhibitory and Inducing Effects of Triphala Formulation on Cytochrome P450 Enzymes" tis.wu.ac.th/index.php/tis/...

"Abstract

Triphala formulation is one of the most common traditional medicines used for several health conditions. The study aimed to investigate the inhibitory and inducing potentials of Triphala formulation, including its active compounds gallic acid and ellagic acid, on cytochrome P450 (CYP450) enzymes. The inhibitory effects of Triphala formulation, gallic acid and ellagic acid on the 5 major human CYP450 enzymes were evaluated using a bioluminescent CYP450 inhibition assay. Evaluation of inducing effect of Triphala formulation on CYP1A2 and CYP3A1 mRNA expression following daily oral doses of 1,000 and 5,000 mg/kg body weight for 28 days was evaluated using RT-PCR. Gallic acid potently inhibited CYP1A2, CYP2C9 and CYP2C19 with a non-competitive nature, while the inhibitory potencies on CYP2D6 and CYP3A4 were weak. Chronic dosing of Triphala formulation at 1,000 and 3,000 mg/kg body weight significantly induced mRNA expression of CYP1A2 but not CYP3A1. Results suggest the propensity of metabolic drug interactions when Triphala formulation was concurrently administered with other conventional drugs or herbal medicines.

HIGHLIGHTS

Gallic acid potently inhibited CYP1A2, CYP2C9 and CYP2C19 with a non-competitive nature

Triphala formulation at the dose of 1,000 and 3,000 mg/kg body weight significantly induced mRNA expression of CYP1A2

Results suggest the propensity of metabolic drug interactions when Triphala formulation is concurrently administered with conventional drugs or herbal products by human CYP450 enzymes, particularly CYP1A2, CYP2C9 and CYP2C19

Conclusions

The results of the in vitro study suggest the propensity of gallic and ellagic acid to inhibit hepatic metabolism of the co-administered herbal products or drugs by human CYP450 enzymes, particularly CYP1A2, CYP2C9 and CYP2C19. The induction study in rats showed the potential inducing effect of Triphala formulation on CYP1A2.

Until the correlation between plasma concentrations of gallic acid/ellagic acid and clinical relevance drug interaction has been confirmed, caution should be exercised when administering Triphala formulation with drugs with narrow therapeutic index values such as warfarin, cyclosporine and digoxin, as well as in patients with impaired hepatic function."

[Meleber in reply to Meleber]

Research: Heliyon

. 2022 Jun 20;8(6):e09764. doi: 10.1016/j.heliyon.2022.e09764

Inhibitory effects of Triphala on CYP isoforms in vitro and its pharmacokinetic interactions with phenacetin and midazolam in rats

Source: pmc.ncbi.nlm.nih.gov/articl...

"This present study is the first to investigate direct in vitro and in vivo evidence of the pharmacokinetic interactions between Triphala and the CYP-probes of phenacetin and midazolam in rats via CYP1A and 3A inhibition.

Clinical caution needs to be thus taken when drugs metabolized by CYP1A2 and/or 3A4 enzymes are used in combination with Triphala extract, since adverse events of these drug may be pronounced by Triphala intake."

[janetmtt]

oh that is a shame wonder why it did that - anyone know the reason why

[Mutleyforever in reply to janetmtt]

Hi, yes I was surprised but it does affect blood flow , maybe lowering blood pressure, usually good things, but if you have pre existing conditions it can interfere, which seems to have occurred 👎

[xjrs]

This is what I found on Triphala side effects, but it doesn't mention your experience, though may be some indirect cause:

onlymyhealth.com/side-effec...

Just goes to show that even natural products can have side effects like medicines do and need to be treated with an element of caution. As with many things you won't know until you try and everyone is different.

[Mutleyforever in reply to xjrs]

Oh yes, herbal remedies can be powerful, not to be taken lightly, that is why I try one thing at a time when it is a new addition!

[xjrs in reply to Mutleyforever]

Great approach 👍🙂.

[janetmtt]

Such a shame as I am thinking of trying it and looking at the blurb it does say it reduces inflammation and can help joint pain etc. Could it have been a kind of detox on you - is it worth trying it again

[Mutleyforever]

Yes I’m sure it has potential and I may go back to it, but if I do have low stomach acid ,I need that to improve really or my digestion will not improve, so back on acv ( apple cider vinegar), wish me luck