Tricyclic Antidepressants have good reviews - IBS Network

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Tricyclic Antidepressants have good reviews

alwayshope111 profile image
7 Replies

I was looking into how an intestine afflicted with IBS functions, and I found two interesting and indepth articles that helped me to understand these functions:

ncbi.nlm.nih.gov/pmc/articl...

badgut.org/information-cent...

They're a bit complicated and took me a while to understand but do give them a look if you can.

My take away from these articles is that tricyclic antidepressants may work to dull or even nullify the gas-associated pain and nausea that comes with IBS. I'm not in the right head space to explain it all in detail, apologies, but long story short, tricyclic antidepressants block certain receptors in the gut that would otherwise send neurotransmitters (such as serotonin) to the brain and set off a painful, nauseous and anxious response.

Two of these antidepressants, Nopramin and Nortryptyline have very good reviews on drugs.com. The dose needed is very small, so hopefully the side effects would be minimal for most. An option to consider if you're already tried many lifestyle changes to no avail.

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7 Replies
janetmtt profile image
janetmtt

Amytriptaline do the same

Bev40 profile image
Bev40

Hi thanks for this info 😃

janke profile image
janke

I`ve been on amitriptyline for many years for a variety of things and now strongly suspect that it has contributed to my bowel problems - in particular a tendency to having to strain when I go to the loo even if the BM is quite soft and needing to go 4 or 5 times a day. My gastroenterologist agrees and so I am now weaning myself off it. Try it to see if it helps - if not, come off it quickly

alwayshope111 profile image
alwayshope111 in reply tojanke

Yeah it can cause constipation in some depending on a few factors. May I ask, what dose are you taking?

janke profile image
janke in reply toalwayshope111

I`ve been on varying doses over the years - maximum 75 mg but mainly 50mg. I`m now down to 10 or 20 mg - I`m having to reduce very slowly because I have been on it so long

alwayshope111 profile image
alwayshope111 in reply tojanke

I hope you can find a dose that works for you, whether you have to come off it entirely or not, whatever makes you feel better. My doctor told me that for me personally he wanted to prescribe 10mg a day, as that usually works and at the same time shouldn't cause side effects. I've not yet tried them, my low carb diet seems to be working for now but if that goes bad I'll start taking them.

Blessedway profile image
Blessedway

This is great research! Good for you and all of us. My doc talked about this and I hear it works.

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