IBS Network
20,531 members6,994 posts

Tricyclic Antidepressants have good reviews

I was looking into how an intestine afflicted with IBS functions, and I found two interesting and indepth articles that helped me to understand these functions:

ncbi.nlm.nih.gov/pmc/articl...

badgut.org/information-cent...

They're a bit complicated and took me a while to understand but do give them a look if you can.

My take away from these articles is that tricyclic antidepressants may work to dull or even nullify the gas-associated pain and nausea that comes with IBS. I'm not in the right head space to explain it all in detail, apologies, but long story short, tricyclic antidepressants block certain receptors in the gut that would otherwise send neurotransmitters (such as serotonin) to the brain and set off a painful, nauseous and anxious response.

Two of these antidepressants, Nopramin and Nortryptyline have very good reviews on drugs.com. The dose needed is very small, so hopefully the side effects would be minimal for most. An option to consider if you're already tried many lifestyle changes to no avail.

7 Replies
oldestnewest

Amytriptaline do the same

Reply

Hi thanks for this info 😃

1 like
Reply

I`ve been on amitriptyline for many years for a variety of things and now strongly suspect that it has contributed to my bowel problems - in particular a tendency to having to strain when I go to the loo even if the BM is quite soft and needing to go 4 or 5 times a day. My gastroenterologist agrees and so I am now weaning myself off it. Try it to see if it helps - if not, come off it quickly

Reply

Yeah it can cause constipation in some depending on a few factors. May I ask, what dose are you taking?

Reply

I`ve been on varying doses over the years - maximum 75 mg but mainly 50mg. I`m now down to 10 or 20 mg - I`m having to reduce very slowly because I have been on it so long

Reply

I hope you can find a dose that works for you, whether you have to come off it entirely or not, whatever makes you feel better. My doctor told me that for me personally he wanted to prescribe 10mg a day, as that usually works and at the same time shouldn't cause side effects. I've not yet tried them, my low carb diet seems to be working for now but if that goes bad I'll start taking them.

Reply

This is great research! Good for you and all of us. My doc talked about this and I hear it works.

1 like
Reply

You may also like...