Has anyone else tried Amitriptyline? 48 hours ago my Doc gave me some to try saying it would help me get a full nights sleep and also help my stomach/bowel to relax at night as my mind is at rest too. Then last night out of the blue I had the worst IBS-D I have had in easily a year. Coincidence? I'm not sure what to think anymore. One minute I seem to feel fine although my stools are never 100% solid then this.