Has anyone any experience with using amitriptyline for IBS? I was on it for a brief period several years ago but stopped after a week due to side effects. I've read online since that these usually subside after 3 weeks. I've been really struggling with my IBS since starting a new job two months ago. I've been on a Fodmap diet but nothing seems to get rid of my symptoms which are mainly abdominal cramps and spasms. I was thinking of asking my GP to prescribe amitriptyline for me again but I wanted to see if anybody had any success with it.