I recently wrote a post about a flare up starting on Friday (20th June) and it's still going on five days later. As soon as I think it's settled down, it goes bad again. It's making me feel unwell and I'm so fed up of it going on, it just doesn't seem to be stopping. I am currently taking amitriptyline 30mg. Started off at 10mg and after a while realised it wasn't working, then went to 20mg and now 30mg and I am still having so many flare ups that last for days and make me feel just horrible. (Sick, tired ect). My GP said we will just have to increase the dosage until it is working but I am starting to wonder if it is working at all or if I just need quite a high dose. It is IBS-D by the way.