I have had 20 years of IBS - no symptoms for weeks/months, then flare ups out of nowhere. As I reached 50 three years ago my flare ups seem to be more painful and disruptive to my life, when they happen. My GP is great and he's very careful and thorough. I wonder whether anyone else has found the same? When you look at the optimum age for IBS it seems to be between 20-40. My anxiety went through the roof after the menopause too - so that could be part of the reason, I just don't know.