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Venetoclax
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classes of drugs for cll
BCI-2-
venetoclax
4. ROR1- circumuzamab 5. monoclonal anti- Gazyva
BCI-2-
venetoclax
4. ROR1- circumuzamab 5. monoclonal anti- Gazyva
Hidden
in
CLL Support
4 years ago
Curious lumps
Through this website I learned that the imbruvica
venetoclax
was not FDA approved he will go to bat for me and argue my case to get approval. Even if they do not approve the drug combination, the
venetoclax
was no where near as expensive as the imbruvica.
Through this website I learned that the imbruvica
venetoclax
was not FDA approved he will go to bat for me and argue my case to get approval. Even if they do not approve the drug combination, the
venetoclax
was no where near as expensive as the imbruvica.
Italianpainter
in
CLL Support
4 years ago
New Clinical Trail EA9161 with great results!
“A Randomized Phase III Study of the addition of
Venetoclax
to Ibrutinib and Obinutuzumab versus Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)”. I had a new CT scan and bone marrow biopsy the week before I started treatment.
“A Randomized Phase III Study of the addition of
Venetoclax
to Ibrutinib and Obinutuzumab versus Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)”. I had a new CT scan and bone marrow biopsy the week before I started treatment.
Riven8
in
CLL Support
4 years ago
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Debulking Eliminates Need for Hospitalization Prior to Initiating Venetoclax Therapy in untreated CLL pts
In the recent CLL14 study, 64% and 22% of
venetoclax
-treated patients were medium and high risk for TLS, respectively.
In the recent CLL14 study, 64% and 22% of
venetoclax
-treated patients were medium and high risk for TLS, respectively.
Jm954
Administrator
in
CLL Support
4 years ago
Critically low white cell count
He's been anemic for months (very low platelets, HGB and red cells) while transitioning to
Venetoclax
/Gazyva combo since after Christmas. After 4 units of blood this weekend his HGB finally raised to 9 from 5 but white cell count is .5 when yesterday it was .9.
He's been anemic for months (very low platelets, HGB and red cells) while transitioning to
Venetoclax
/Gazyva combo since after Christmas. After 4 units of blood this weekend his HGB finally raised to 9 from 5 but white cell count is .5 when yesterday it was .9.
Anavadya
in
CLL Support
4 years ago
SKIP VENETOCLAX, GO TO ACALABRUTINIB
My oncologist/hematologist indicated the treatment would be
Venetoclax
. I see the specialist on a consultation basis. Anyone face this situation?
My oncologist/hematologist indicated the treatment would be
Venetoclax
. I see the specialist on a consultation basis. Anyone face this situation?
cll2013
in
CLL Support
4 years ago
ASH 2019: U-MRD by subgroup (ibrutinib+venetoclax) CAPTIVATE trial
This is how we achieve personalized, precision medicine. 73% of patients achieved U-MRD4 in BM after 12 cycles of ibrutinib +
venetoclax
. This is shown as the dashed vertical line. Interestingly, the lowest U-MRD4 is the IGHV mutated subgroup. Hmm.
This is how we achieve personalized, precision medicine. 73% of patients achieved U-MRD4 in BM after 12 cycles of ibrutinib +
venetoclax
. This is shown as the dashed vertical line. Interestingly, the lowest U-MRD4 is the IGHV mutated subgroup. Hmm.
avzuclav
in
CLL Support
4 years ago
CD3xCD19 Dart Treatment Is Efficient in Venetoclax Resistant CLL and Reverses T Cell Dysfunction
and will be effective against
venetoclax
resistant CLL.
and will be effective against
venetoclax
resistant CLL.
Jm954
Administrator
in
CLL Support
4 years ago
venclexta and Imbruvica both owned by same company
Just for thought- i copied a paragraph from an article i read The study was supported by AbbVie, the manufacturer of
venetoclax
. AbbVie also owns Pharmacyclics, the manufacturer of ibrutinib . Several authors report relationships with industry, including AbbVie, as detailed in the article.
Just for thought- i copied a paragraph from an article i read The study was supported by AbbVie, the manufacturer of
venetoclax
. AbbVie also owns Pharmacyclics, the manufacturer of ibrutinib . Several authors report relationships with industry, including AbbVie, as detailed in the article.
Hidden
in
CLL Support
4 years ago
I have irregular heartbeat and treatment
Is it true that I can't take Ibrutinib or
Venetoclax
to treat my CLL. Is anyone familiar with this in the community. Thank You
Is it true that I can't take Ibrutinib or
Venetoclax
to treat my CLL. Is anyone familiar with this in the community. Thank You
Test_Tech
in
CLL Support
4 years ago
New Study: Study of Ibrutinib Resistance Development and Intervention with Venetoclax in CLL
This will determine: the incidence of Ibrutinib Resistance Mutations (IRmut) and Progressive Disease (PD) in this population, the ORR with Ibrutinib/
Venetoclax
, and the ability of this combination to eliminate IRmutations.
This will determine: the incidence of Ibrutinib Resistance Mutations (IRmut) and Progressive Disease (PD) in this population, the ORR with Ibrutinib/
Venetoclax
, and the ability of this combination to eliminate IRmutations.
Jm954
Administrator
in
CLL Support
4 years ago
First line above at 69Y: Venetoclax vs Ibrutinib vs BR
Is
Venetoclax
good first line treatment option? Regards
Is
Venetoclax
good first line treatment option? Regards
paula_dae
in
CLL Support
4 years ago
Venetoclax Added to Ibrutinib in High-Risk CLL Achieves a High Rate of Undetectable Minimal Residual Disease.
I would welcome the chance to add
venetoclax
to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients receiving the BTK inhibitor ibrutinib (ibr) for CLL rarely achieve CR with undetectable MRD (U-MRD) and require indefinite suppressive therapy.
I would welcome the chance to add
venetoclax
to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients receiving the BTK inhibitor ibrutinib (ibr) for CLL rarely achieve CR with undetectable MRD (U-MRD) and require indefinite suppressive therapy.
Jm954
Administrator
in
CLL Support
4 years ago
News about V+O and Acalabrutinib from EHA
Peter Hillman discusses one of the most promising,
Venetoclax
and Obinutuzumab. See https://cllsociety.org/2019/11/eha-2019-dr-peter-hillman-on-
venetoclax
-and-obinutuzumab-in-cll-chronic-lymphocytic-leukemia/ At EHA 2019, Dr.
Peter Hillman discusses one of the most promising,
Venetoclax
and Obinutuzumab. See https://cllsociety.org/2019/11/eha-2019-dr-peter-hillman-on-
venetoclax
-and-obinutuzumab-in-cll-chronic-lymphocytic-leukemia/ At EHA 2019, Dr.
bkoffman
CLL CURE Hero
in
CLL Support
4 years ago
A Phase 1/2 Study of Umbralisib, Ublituximab and Venetoclax in Patients with R/R CLL
Combining these agents with the BCL2 inhibitor
venetoclax
(Ven) may prevent drug resistance (Choudhary, Cell Death Dis 2015), avoid tumor lysis syndrome (TLS) and achieve undetectable minimal residual disease (MRD).
Combining these agents with the BCL2 inhibitor
venetoclax
(Ven) may prevent drug resistance (Choudhary, Cell Death Dis 2015), avoid tumor lysis syndrome (TLS) and achieve undetectable minimal residual disease (MRD).
Jm954
Administrator
in
CLL Support
4 years ago
Mantle Cell Lymphoma - Window 2 clinical trial
Then another 2-3 years in maintenance with Ibrutiniv,
Venetoclax
and Rituximab. Any idea or advice, please whether to join this trial?
Then another 2-3 years in maintenance with Ibrutiniv,
Venetoclax
and Rituximab. Any idea or advice, please whether to join this trial?
writepa
in
CLL Support
5 years ago
Treatment Coverage Under Medicare
Hello everyone, My husband is Medicare eligible and currently on watch and wait, but he is nearing treatment most likely with a drug such as Imbruvica or
Venetoclax
. Does anyone here know how these new drugs are classified per Medicare?
Hello everyone, My husband is Medicare eligible and currently on watch and wait, but he is nearing treatment most likely with a drug such as Imbruvica or
Venetoclax
. Does anyone here know how these new drugs are classified per Medicare?
bingbang
in
CLL Support
4 years ago
Updated Results: Combined Ibrutinib and Venetoclax for 1st lineTreatment for CLL
Michael J Keating et al Dec 2019 - ASH oral presentation Here they report updated data for the 80 pts with focus on MRD results. After 12 cycles of the combination, 45/69 (65%) achieved BM U-MRD remission. After 24 cycles of the combination, 23/29 (79%) achieved BM U-MRD remission. A total of 12 (15%
Michael J Keating et al Dec 2019 - ASH oral presentation Here they report updated data for the 80 pts with focus on MRD results. After 12 cycles of the combination, 45/69 (65%) achieved BM U-MRD remission. After 24 cycles of the combination, 23/29 (79%) achieved BM U-MRD remission. A total of 12 (15%
Jm954
Administrator
in
CLL Support
4 years ago
Mantle Cell Lymphoma Treatment
Just wonder if anyone participates in Window 2 clinical trial of MD Anderson where patients receive Ibrutinib in the first 4 months, combine with Rituximab and add
Venetoclax
in month 5. Chemo will be followed if in the medium and high risk.
Just wonder if anyone participates in Window 2 clinical trial of MD Anderson where patients receive Ibrutinib in the first 4 months, combine with Rituximab and add
Venetoclax
in month 5. Chemo will be followed if in the medium and high risk.
writepa
in
Non Hodgkin's Lymphoma Friends
5 years ago
Venetoclax too?
Does this also apply to a reduction in dosing or temporary halting of
Venetoclax
due to low WBC?
Does this also apply to a reduction in dosing or temporary halting of
Venetoclax
due to low WBC?
emmiekay
in
CLL Support
5 years ago
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