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CLL Society ASH 2021 Highlights from Day 2 of ASH 2021! Dr. Brian Koffman gives up updates
Brian Koffman gives up updates on the reversible non-covalently binding BTKi (Bruton’s
tyrosine
kinase inhibitor) pirtobrutinib (formerly LOXO-305), another reversable BTKi known as MK-1026 (formerly ARQ-531), 3-year follow-up data from the Ascend Trial: Acalabrutinib vs Rituximab plus Idelalisib
Brian Koffman gives up updates on the reversible non-covalently binding BTKi (Bruton’s
tyrosine
kinase inhibitor) pirtobrutinib (formerly LOXO-305), another reversable BTKi known as MK-1026 (formerly ARQ-531), 3-year follow-up data from the Ascend Trial: Acalabrutinib vs Rituximab plus Idelalisib
bkoffman
CLL CURE Hero
in
CLL Support
2 years ago
Medication help!
I have just changed over from armour NDT to tirosint and compounded t3. My t3 is in capsules so I can not split this dose twice in a day. I ended up having to take both before bed 2 hours after food. I am better taking my meds at bedtime due to side effects etc. I feel awful today after doing a straight
I have just changed over from armour NDT to tirosint and compounded t3. My t3 is in capsules so I can not split this dose twice in a day. I ended up having to take both before bed 2 hours after food. I am better taking my meds at bedtime due to side effects etc. I feel awful today after doing a straight
Ajva
in
Thyroid UK
2 years ago
How to split tirosint and t3 properly
I have finally been able to source tirosint and compounded t3 in the uk!! I am going on 50mg of tirosint and 11mg t3. However I am not sure how to split this dose through out the day. I am on armour 1 1/4 grains and I take this split morning and before bed. I did like the armour but I am still getting
I have finally been able to source tirosint and compounded t3 in the uk!! I am going on 50mg of tirosint and 11mg t3. However I am not sure how to split this dose through out the day. I am on armour 1 1/4 grains and I take this split morning and before bed. I did like the armour but I am still getting
Ajva
in
Thyroid UK
2 years ago
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Key ChallengesTo Inhibiting BTK
Bruton's
tyrosine
kinase (BTK) promotes the growth and survival of malignant B cells1 Sustained inhibition of BTK must be maintained at therapeutic concentrations in target tissues2 An interesting read@ https://www.brukinsa.com/hcp/btk-inhibition-challenges?
Bruton's
tyrosine
kinase (BTK) promotes the growth and survival of malignant B cells1 Sustained inhibition of BTK must be maintained at therapeutic concentrations in target tissues2 An interesting read@ https://www.brukinsa.com/hcp/btk-inhibition-challenges?
Tupelomojo
in
CLL Support
3 years ago
T4 dosing every other day?
I have just purchased tirosint t4 50mg caps. I have many and now need to reduce t4 down to 25 a day but can’t split them as they are oil caps. So can I just take 1 50mg cap every other day and it would work the same?
I have just purchased tirosint t4 50mg caps. I have many and now need to reduce t4 down to 25 a day but can’t split them as they are oil caps. So can I just take 1 50mg cap every other day and it would work the same?
ter1461
in
Thyroid UK
2 years ago
"A change in diet may reduce risk of lethal prostate cancer" Your thoughts on the study results below?
It is an essential part of many proteins and enzymes in the body and, when converted to
tyrosine
, is used to make the neurotransmitter dopamine. CholineTrusted Source is found mainly in animal products, such as meat, fish, eggs, and dairy, although pulses, nuts, and seeds are sources for vegans.
It is an essential part of many proteins and enzymes in the body and, when converted to
tyrosine
, is used to make the neurotransmitter dopamine. CholineTrusted Source is found mainly in animal products, such as meat, fish, eggs, and dairy, although pulses, nuts, and seeds are sources for vegans.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Did the Georgetown University Plan Stand a Chance?
appid=3a69da6e2e0544a7b0978790f8d31ad0 How Gleevec Transformed Leukemia Treatment and Cancer Research: For those that would like a little history on
tyrosine
kinase inhibitors.
appid=3a69da6e2e0544a7b0978790f8d31ad0 How Gleevec Transformed Leukemia Treatment and Cancer Research: For those that would like a little history on
tyrosine
kinase inhibitors.
Isthistheone
in
Cure Parkinson's
2 years ago
What to do about T3 anxiety?
Hi Everyone, I was Diagnosed with Hashimotos in 2011. Started with 25mcg Synthroid, over a number of years settled on 80 mcg Levothyroxine compounded SR with 12 mcg Liothyronine. Had thyroid lobectomy in November 2021 and my new endocrinologist switched me to 88 mcg Tirosint and 5 mcg Cytomel. I am experiencing
Hi Everyone, I was Diagnosed with Hashimotos in 2011. Started with 25mcg Synthroid, over a number of years settled on 80 mcg Levothyroxine compounded SR with 12 mcg Liothyronine. Had thyroid lobectomy in November 2021 and my new endocrinologist switched me to 88 mcg Tirosint and 5 mcg Cytomel. I am experiencing
KarmaMaya
in
Thyroid UK
2 years ago
Adding t3
I am on 50 mg of t4 and have very low t3 so now looking at adding some t3 in. How much would be a normal amount to add as it’s at the bottom of the range and should I also reduce t4? I’m on tirosint which is oil so the capsule can’t be split
I am on 50 mg of t4 and have very low t3 so now looking at adding some t3 in. How much would be a normal amount to add as it’s at the bottom of the range and should I also reduce t4? I’m on tirosint which is oil so the capsule can’t be split
ter1461
in
Thyroid UK
2 years ago
Internal Trembling, tinnitus and Insomnia
Ive been on the quest for thyroid health the "Natural way" for 4-5 years now. Originally Diagnosed with Hashimotos. Naturthroid or Something made me go hyper and I was diagnosed with High Graves antibodies..... and then Thyroid eye disease. :-(, Histamine intolerance etc... I did the AIP diet and
Ive been on the quest for thyroid health the "Natural way" for 4-5 years now. Originally Diagnosed with Hashimotos. Naturthroid or Something made me go hyper and I was diagnosed with High Graves antibodies..... and then Thyroid eye disease. :-(, Histamine intolerance etc... I did the AIP diet and
JannSimpson
in
Thyroid UK
2 years ago
Hypothyroid misery! would appreciate on my latest lab results
I take vitamin d, an iron supplement, hydroxocobalamin and adenosylcobalamin,
tyrosine
, zinc, selenium... I would welcome any informed commentary on my labs and situation as I will be meeting with the new practitioner again in five days...
I take vitamin d, an iron supplement, hydroxocobalamin and adenosylcobalamin,
tyrosine
, zinc, selenium... I would welcome any informed commentary on my labs and situation as I will be meeting with the new practitioner again in five days...
pecantrees
in
Thyroid UK
3 years ago
Neuroendocrine Prostate Cancer [NEPC]
Etk/Bmx, a
tyrosine
kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A 1998;95:3644-9. [Crossref] [PubMed] Kim J, Adam RM, Freeman MR.
Etk/Bmx, a
tyrosine
kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc Natl Acad Sci U S A 1998;95:3644-9. [Crossref] [PubMed] Kim J, Adam RM, Freeman MR.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Antibody test, optimal timing
hi from Poland I have been on Zanubrutinib (small molecule inhibitor of Bruton's
tyrosine
kinase) for three years. I had a moderna booster two weeks ago. I wonder after how long to do the antibody test.
hi from Poland I have been on Zanubrutinib (small molecule inhibitor of Bruton's
tyrosine
kinase) for three years. I had a moderna booster two weeks ago. I wonder after how long to do the antibody test.
BART4
in
CLL Support
2 years ago
Tirosint who have you used to get this prescription in the uk?
Has anyone uk based found a Dr or endo that can prescribe Tirosint or synthroid levo brands? I know by the list there are pharmacies that do prescribe it in the uk. I am just unsure who you go through to obtain this prescription?
Has anyone uk based found a Dr or endo that can prescribe Tirosint or synthroid levo brands? I know by the list there are pharmacies that do prescribe it in the uk. I am just unsure who you go through to obtain this prescription?
Ajva
in
Thyroid UK
2 years ago
Is It Time to Panic Now?
I've been feeling great on the Tirosint. Maybe too great. I talked my endo into a blood test just so we had range numbers. My TSH went from 0.5 last month to 5.0 this month. Endo did not test vitamins so I don't know my B12 or Ferrrtin. Endo and GP refuse to refer to oncology. My thyroid came out
I've been feeling great on the Tirosint. Maybe too great. I talked my endo into a blood test just so we had range numbers. My TSH went from 0.5 last month to 5.0 this month. Endo did not test vitamins so I don't know my B12 or Ferrrtin. Endo and GP refuse to refer to oncology. My thyroid came out
Audley1013
in
Thyroid UK
2 years ago
Should I have the goiter removed?
The immunologist put me on very high levels of D3/K2, b12, folate, all the B's omegas, oil of primrose, l-
tyrosine
, which I've taken religiously for over 6 months and it hasnt budged my thyroid function. In fact it's just kept dropping. TSH, T3 and T4.
The immunologist put me on very high levels of D3/K2, b12, folate, all the B's omegas, oil of primrose, l-
tyrosine
, which I've taken religiously for over 6 months and it hasnt budged my thyroid function. In fact it's just kept dropping. TSH, T3 and T4.
kaju20
in
Thyroid UK
3 years ago
Supplements for C-myelopathy
I added other supplements like lysine,
tyrosine
, phosphatidyl choline and Vit. E, D, krill oil, zinc, etc. and without these energy and ataxia are much worse. I just joined so wanting to know if anyone is taking something that really makes a difference esp. with lack of oxygen in the brain.
I added other supplements like lysine,
tyrosine
, phosphatidyl choline and Vit. E, D, krill oil, zinc, etc. and without these energy and ataxia are much worse. I just joined so wanting to know if anyone is taking something that really makes a difference esp. with lack of oxygen in the brain.
rideabike
in
Cervical Myelopathy
3 years ago
Tyrosine?
Hi, Anyone on here tried supplementing
tyrosine
to help with thyroid issues? Thanks A
Hi, Anyone on here tried supplementing
tyrosine
to help with thyroid issues? Thanks A
Compostella1
in
Thyroid UK
3 years ago
Availability Levothyroxine Brands
Hi, I have an allergy to acacia and have been taking the brand Aristo for some time as it has no Acacia or Lactose. Its becoming almost impossible to source this brand myself as most pharmacies are now sent Teva from their suppliers. What options are their that I could try as its coming to the point
Hi, I have an allergy to acacia and have been taking the brand Aristo for some time as it has no Acacia or Lactose. Its becoming almost impossible to source this brand myself as most pharmacies are now sent Teva from their suppliers. What options are their that I could try as its coming to the point
UB40Pug
in
Thyroid UK
2 years ago
REFINING MY PREVIOUS QUESTION (,,, food for thought): should it be preferable in PSP to take phenylalanine instead of tyrosin supplements?
Tyrosine
is a dopamine percursor and as such appears to be a good option for supplementation in PSP. “
Tyrosine
hydroxylase” is the enzyme responsible for catalyzing the conversion of the amino acid L-
tyrosine
to L-DOPA.
Tyrosine
is a dopamine percursor and as such appears to be a good option for supplementation in PSP. “
Tyrosine
hydroxylase” is the enzyme responsible for catalyzing the conversion of the amino acid L-
tyrosine
to L-DOPA.
BluesHealer
in
PSP Association
3 years ago
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