Experiences with

Sirolimus

https://www.pdsa.org/products-a-publications/e-news/2018-enews/item/1613-pdsa-enews-032818.html Rapamycin is being tested as a longevity drug.. It is not "approved" as an IPT drug, but it is available by prescription. I have heard of people ordering it from off shore sources. It is a generic drug

The aging brain exhibits a region-specific reduction in synapse number and plasticity. Although astrocytes play central roles in regulating synapses, it is unclear how changes in astrocytes contribute to age-dependent cognitive decline and vulnerability to neurodegenerative diseases. Here, we identified

Over the last few months, I've been noticing some trends, and as I spent another nearly sleepless night reading and watching videos, some of the pieces seem to be fitting together. In short, it seems that more and more theories and studies are focusing on mitochondria. In particular, a "biochemical defect

Thankfully copies are low and now on 1mg of Sirolimus to keep copies low Taking 0.5 Advagraf now as LFT's are still excellent and all well within range and the reduction has helped renal numbers dramatically. Anyone living with the HV88 virus?

Rapamycin (aka Sirolimus) is a very interesting drug of diverse effects. It is being explored in early trials for PC because of positive effects demonstrated in cell cultures of PC cell lines and in animal model (mice).

Conclusions: Rapamycin inhibits the activation of mTOR pathway, which contributes to protect against the loss of dopaminergic neurons and provide behavioral improvements in mice with Parkinson's disease. These results are partially related to the ability of rapamycin in inducing autophagy and reducing

Immunosuppressed Patients Respond to Booster Shots: Hope for a COVID Booster Vaccine for Lupus and Other Autoimmune Disease Patients? [Updated 8/12/21] August 11, 2021 TABLE OF CONTENTS 1) Will a COVID Booster Vaccine for Lupus Patients Increase Response Rates? 2) The COVID Booster Vaccine Study

Radiolab did an amazing piece on rapamycin: https://www.wnycstudios.org/podcasts/radiolab/articles/dirty-drug-and-ice-cream-tub "This episode, a tale of a wonder drug that will make you wonder about way more than just drugs. Doctor-reporter Avir Mitra follows the epic and fantastical journey of a

I am interested because of its' ability to stimulate autophagy in the mitochondria. https://www.lifeextension.com/magazine/2021/3/reduce-damaged-cells

Sirolimus (rapamycin) is the first, and only, treatment approved by the FDA for the treatment of LAM. However, this drug is not effective or well tolerated by some LAM patients, and declining lung function has been shown to continue after treatment.

All patients on the following medications have been centrally identified and will be contacted via the letter: • Azathioprine • Mycophenolate (both types) • Cyclosporin • Sirolimus • Tacrolimus [UNQUOTE] Hope this helps..

Trial IPT Drug https://www.pdsa.org/products-a-publications/e-news/2018-enews/item/1613-pdsa-enews-032818.html Rapamycin is an interesting drug. First, in trials as a cure for (I think) athletes' foot, it was never marketed for that because it was a powerful immune suppressor. It became the "go to

Patients also received oral doses of methoxsalen (10 mg), phenytoin (50 mg), and sirolimus (0.5 mg) once per day. Most patients had previously received ADT after radiation therapy or surgery, but ADT treatment was not permitted during the trial.

Findings In this cohort study of US recipients of lung transplants, sirolimus plus tacrolimus was associated with significantly better conditional survival from 1 year after transplant compared with mycophenolate mofetil plus tacrolimus (median survival, 8.9 vs 7.1 years after transplant).

Docetaxel is a common therapuetic used in advanced prostate cancers. There are some combinations you can ask your doctor about that will definitely and safely maximize its effects. Obviously we all all heard of radiation resistance but there is also such a thing as chemo drug-resistance. Countless research

Hi, I’m almost 6 months post transplant and my creatinine is around 2.2 and my doctors want me to go on sirolimus and stop my cellcept. I wanted to know is anyone taking sirolimus and have you had side effects?

Recently, my doctor is using rapamycin test on ald children patients. The test is from this literature, but the literature was published in 2015. Is there any similar test conducted in other places? https://link.springer.com/article/10.1007/s00401-014-1378-8

Hi everyone came across Gou Teng and have been trying for the last 3months. I find it does help with my tremor and energy. Thought I’d post and see what you think, I had never heard of it . Wishing everyone the best 🙂 Can you tell me about the Chinese herb gou teng, which I understand is helpful

Good article that provides an update - LOTS going on!! Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resistant Prostate Cancer Bryden Considine, DODaniel P. Petrylak, MD March 13, 2019 Volume: 33Issue: 3 Prostate

Has anyone been on sirolimus or is on it? Leeds are talking about putting me on this as my kidneys are not getting any better on advagraf, but I have heard a few bad things about this medication