Experiences with

Nilutamide

This was initially described for older agents, such as flutamide, bicalutamide, and nilutamide; moreover, before the approval of enzalutamide and abiraterone, this phenomenon could be used to postpone the beginning of chemotherapy in mCRPC [7]. AAWS after enzalutamide is not well established.

My Dads new oncologist switched his steroid from prednisolone to dexamethasone - she was distressed at first appointment to see he was on zytiga and prednisolone. She said research pretty clear that dexamethasone is better. On today's PSA results she is clearly correct. We thought that he had become

"Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard non-steroidal antiandrogen ([NSAA] bicalutamide, nilutamide, or flutamide), or enzalutamide at 160 mg per day plus TS in arm B. " "The 5-year OS rates were 81% and 66% for those with

Seems to imply that the only ones you really need are bicalutamide or nilutamide (!).

When getting Eligard shots after prostatectomy and radiation it was holding PSA level down. It also turned my thoughts angry and disgruntled. Doctor Larock from Mattapoisett is treating me with Flutamide and Bicalutimide 1 pill day each. Thanks Jesus I can write this and feel pretty good for 75. Eligard

New paper below [1]. "Between Nov 15, 2011, and Jan 17, 2014, 1003 patients were randomly assigned to standard of care (n=502) or standard of care plus abiraterone (n=501) in the abiraterone trial. "Between July 29, 2014, and March 31, 2016, 916 patients were randomly assigned to standard of care

This is a very informative research paper on the mechanisms involved with current treatments that target the AR in PCa. Interestingly, it compares/contrast the actions (both as agonistic and antagonistic) of the ADT drugs (Bicalutamid, Flutamide, Enzalutamide, Apalutamide, Darolutamide, & Hydrocortisone

Here is a very cool link on all the inhibitors. This link is awesome and it covers all inhibitors for all of the cancer pathways. Half way down under "Other Androgen Receptor Products" you will see two graphics; one is "Download Inhibitor Catalog", the other is download the "Androgen Receptor Signaling

Antiandrogens include bicalutamide (Casodex), nilutamide (Nilandron), enzalutamide (Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa). PSA, prostate-specific antigen. [Color figure can be viewed at wileyonlinelibrary.com] 2.3 Why does prostate cancer become castration resistant?

Cheerr had asked: "Which test is recommended for Pca patients - Total or Free." I belatedly remembered a German study [1] that took a look at the issue. This could be important - hence the new post. "Despite the fact that free testosterone (FT) is the biologically active form, it is common practice

According to the cancer.gov fact sheet for Hormone Therapy for Prostate Cancer, there are 5 types of CAB, Complete Androgen Blockade. I've been on bical. for about 20 months. However, against advice, I have not had radiation nor surgery. The combo I'm using is finasteride, tamsulosin and bicalutamide

I was doing some research on ARL702H, which the Guardiant360 revealed for my husband. I think ARL702H is brought on from being on Zytiga + prednisone. - and this may be why switching from predisone to dexamethasone can help the Zytiga to continue working: Role of Androgen Receptor in Prostate Cancer

New paper from Japan [1]. The antiandrogen flutamide was approved by the FDA for PCa thirty years ago. Bicalutamide had been approved by the FDA a few years earlier. The paper presents an anecdotal case of a man "in whom flutamide controlled disease progression for 10 years" "after bicalutamide failure

(Textbook of pharmacology and therapeutics discusses the androgen receptor antagonists flutamide, bicalutamide, nilutamide and enzalutamide, but not apalutamide). https://www​.accessdata​.fda.gov/scripts/cder/daf/ (FDA Drug Approvals website that has product labels [package inserts], letters of approval

Replacement of Bicalutamide and (God forbid a toxic Nilutamide). While visiting relatives in Europe my Urologist there was suggesting ; KETOCONAZOLE As a Bicalutamide replacement. I am still on 4 month LUPRON . Any experience or comment on this please. Thanks and greetings to all ! Victor

"To celebrate the [i]Prostate Cancer and Prostatic Diseases[/i] satellite meeting in Shangai on 7 December 2018, Dr Stephen Freedland and Dr Dingwei Ye selected some of our top papers from China." https://www.nature.com/documents/PCAN_Best_of_China_collection_v2.pdf I was particularly interested in

My husband, age 58, was diagnosed July 2016. PSA 477, Gleason 9. Oncologist advised against any treatment. Urologist started with Firmagon, monthly. He suggested Docetaxel - oncologist later agree and chemo treatment started - treatment was tolerated well. Different treatments were introduced: Prednisone

We have plenty of them now. Flutamide, nylutamide, bicalutamidee, ensulutamide, ampulutamide, darolutamide. Are there any more? There are also adjuncts to these. I use avodart, some in clinical trials. I failed casodex after 7+ yrs than xtandi for a year with lupron which I think wasn't necessary since

New study below. Six months back I started a thread: "Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)" https://healthunlocked.com/advanced-prostate-cancer/posts/137369286/non-pca-prescription-drugs-thalidomide-lenalidomide-revlimid 18 months earlier, I had posted the Mainsail trial

hello all! As some of you know, i've started taking Synthroid about a month ago (25 mcgs/ day) Still haven't gone back for my 6 weeks to potentially up the dose. I'm also taking 5000 IU of Vitamin D3 + 50 mcg of K2 every other day. I'm also supposed to start taking Flutamide (anti-androgen) for my PCOS