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Scientists devise novel strategy to seek and destroy leukemia stem cells
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
** Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings. By overcoming challenges, such as
PhysAssist
in
MPN Voice
6 months ago
BESREMi now recommended as a Preferred First-line Cytoreductive Therapy for PV in Updated NCCN Clinical Practice Guidelines in Oncology
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
« The National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (NCCN Guidelines®) have recently been updated to include ropeginterferon alfa-2b-njft, marketed as BESREMi®, as a preferred first-line cytoreductive therapy option for the treatment of adults with symptomatic, low-risk
Manouche
in
MPN Voice
6 months ago
HU and Osteoblasts
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
Hi Group, I have ET Jak2 + and am 64yrs old My bone mass has been declining faster than I would have expected given my level of activity, genetic history and diet. I have seen some information that HU affects the production of osteoblasts as well. My info is from a quick read of Hydroxyurea Induces
nightshadow
in
MPN Voice
6 months ago
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Best treatment for Post PV/MF ?
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
I'm wondering Which medication is more effective for post pv/mf. Ruxolitinib or interferon? I was diagnosed with pv in 2017. 2 years of hydroxy, then ruxolitinib at 20mg a day. A bmb in december showed progression to mf. Grade 2 fibrosis. The rux has recently been increased to 30mg a day along with
MCW22
in
MPN Voice
6 months ago
Anyone with CLL and Myelodysplasia
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Anyone with CLL and Myelodysplasia? A month ago I was diagnosed with Myelodysplasia after undergoing a biopsy when I was at the end of the Venetoclax treatment.
Priss69
in
CLL Support
6 months ago
Transplant Route
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Hi everyone. I was diagnosed with primary MF 9 years ago and have been relatively well managed on Ruxolitinib for most of that time. Recently however my platelets have been consistently low, 37, 56, 59 and about same now. My spleen has enlarged again and I have been put on a reduced dose of Ruxolitinib
Cazbolac
in
MPN Voice
6 months ago
Request for experiences with Vitamin D
If anyone of you would be willing to share your personal experience with Vitamin D that would be appreciated. All good with what is thought to be true in the medicial field I am well versed in that angle. I have taken D3 with K2 and the results were not definitive so I discontinued. I have lived
If anyone of you would be willing to share your personal experience with Vitamin D that would be appreciated. All good with what is thought to be true in the medicial field I am well versed in that angle. I have taken D3 with K2 and the results were not definitive so I discontinued. I have lived
WIZARD6787
in
Pernicious Anaemia Society
10 days ago
We're closing this forum
After thorough consideration and evaluation, we want to inform you that Leukaemia Care's HealthUnlocked Online Forum Service will be closing on the 30th April 2024. Despite the closure of the HealthUnlocked forum, Leukaemia Care remains committed to supporting individuals affected by leukaemia through
After thorough consideration and evaluation, we want to inform you that Leukaemia Care's HealthUnlocked Online Forum Service will be closing on the 30th April 2024. Despite the closure of the HealthUnlocked forum, Leukaemia Care remains committed to supporting individuals affected by leukaemia through
NicoleLeukaemiaCare
in
Leukaemia Support
7 months ago
JAK2 Allele Frequency/Burden
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
I am a 69-year-old female and was diagnosed with polycythemia vera in November 2023. I have been taking hydroxyurea since the middle of November it has helped my numbers and my symptoms. I am seeing a very reputable oncologist/hematologist - there are no MPN specialist in my area. I am JAK-2 positive
FlannelPJs
in
MPN Voice
7 months ago
NO CD20? How concerned to be?
Hi all! Went in with a recently diagnosed loved one to an oncology appointment recently. I don’t have FISH back yet, but I found out (at least preliminary) flow showed CD20 negative. Doctor Google sent me into a panic stating this was very not great news for NH lymphoma patients. But then it also said
Hi all! Went in with a recently diagnosed loved one to an oncology appointment recently. I don’t have FISH back yet, but I found out (at least preliminary) flow showed CD20 negative. Doctor Google sent me into a panic stating this was very not great news for NH lymphoma patients. But then it also said
anongirll1927
in
CLL Support
14 days ago
Following LeoPa's “On CLL, diet and possible connections.”
I am also curious about the preferred energy source of CLL cells. Particularly the cholesterol role. If the CLL cells use cholesterol do they use whatever is present, or is there a signaling going on telling/initiating production—that causes cholesterol to rise? Below are a few articles I found on
I am also curious about the preferred energy source of CLL cells. Particularly the cholesterol role. If the CLL cells use cholesterol do they use whatever is present, or is there a signaling going on telling/initiating production—that causes cholesterol to rise? Below are a few articles I found on
Lavinia-Blue
in
CLL Support
15 days ago
Hot Sauna for CLL Patients
I am diagnosed with CLL since 2021 and curregtiy on W&W with relatively stable WBC. I have hot sauna in my building gym. Is it beneficial for me to do hot sauna once a week or can sauna trigger CLL to activate into a fast progression? Thank you
I am diagnosed with CLL since 2021 and curregtiy on W&W with relatively stable WBC. I have hot sauna in my building gym. Is it beneficial for me to do hot sauna once a week or can sauna trigger CLL to activate into a fast progression? Thank you
Lovely67
in
CLL Support
26 days ago
Allograft
Just wanted to know if anyone knew anything about Allograft. My husband has just finished 2 yrs on ventaclax, all blood's good, and we expected to just go away and go back for blood's until maybe time for a different treatment, but was told they would like us to have a chat to a specialist about allograft
Just wanted to know if anyone knew anything about Allograft. My husband has just finished 2 yrs on ventaclax, all blood's good, and we expected to just go away and go back for blood's until maybe time for a different treatment, but was told they would like us to have a chat to a specialist about allograft
sue6741
in
CLL Support
30 days ago
Median PFS for FCR treated CLL patients with IGHV-M was 14.6 years vs 4.2 years for patients with IGHV-UM. V+O and I+R look to be superior
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
AussieNeil
Partner
in
CLL Support
1 month ago
GVHD and skin dryness.
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Unfortunately I have chronic graft versus host desiese of the skin and have controlled it with a steroid cream since my ASCT a year and a half ago. My only issue currently is that I find it hard to look after the skin on my hands and feet that are dry and chapped. I have used quite a few emoluments
Kraskie1915
in
CLL Support
7 months ago
Not officially diagnosed...in watch and wait
As the title says, I'm in the WW stage. I saw a hematologist 5 years ago about my lymphocytosis and he felt he could not give a definitive diagnosis. In March this year, I had some stomach issues and bloodwork (above). A peripheral blood smear was done. Below are the notes: There is mild leukocytosis
As the title says, I'm in the WW stage. I saw a hematologist 5 years ago about my lymphocytosis and he felt he could not give a definitive diagnosis. In March this year, I had some stomach issues and bloodwork (above). A peripheral blood smear was done. Below are the notes: There is mild leukocytosis
Purplecat1919
in
CLL Support
2 months ago
root canals
hi all , I have been on the W and W program. My blood dis-order was discovered in 2019. I referred to it as a blood disorder as they still haven’t taken a bone marrow sample to confirm that it’s truly CLL. I am curious if anyone in the group has tried removing any old root canals to see if it
hi all , I have been on the W and W program. My blood dis-order was discovered in 2019. I referred to it as a blood disorder as they still haven’t taken a bone marrow sample to confirm that it’s truly CLL. I am curious if anyone in the group has tried removing any old root canals to see if it
Jrugg
in
CLL Support
2 months ago
Puzzled
Hi folks! Hope we're all travelling well. Can I tap into your collective wisdom and experience? I've just come back from my regular check up with the CLL specialist. My ALC has gone from 29 to 53 in 6 months, or 91% of the blood count. Before then, it was steadily rising, but dropping at intervals. The
Hi folks! Hope we're all travelling well. Can I tap into your collective wisdom and experience? I've just come back from my regular check up with the CLL specialist. My ALC has gone from 29 to 53 in 6 months, or 91% of the blood count. Before then, it was steadily rising, but dropping at intervals. The
Guffy
in
CLL Support
2 months ago
Re-inoculate?
Hello you wonderful and oh-so-knowledgeable folks! This is a good-news story. After 11 months on a zanu-obin-venetoclax trial I've been in remission for 3 years. AND a lymphocyte subset test suggests that my B cells are coming back! Now here's my question: while I was on treatment and in the past
Hello you wonderful and oh-so-knowledgeable folks! This is a good-news story. After 11 months on a zanu-obin-venetoclax trial I've been in remission for 3 years. AND a lymphocyte subset test suggests that my B cells are coming back! Now here's my question: while I was on treatment and in the past
mouseandchair
in
CLL Support
2 months ago
CLL/CML treatment update
Hi All, Thank you for your passed and continuing help and support. Been taking dasatsnib since 2018 or 2019; with 1 incidence of Pleural effusion/thoracenticis, etc., in 2021. —that’s when I switched to Dr Cortes. zwent from 100mg to 20. For last 2-3 years. Dx’d in 2014. I have CLL and CML simultaneously
Hi All, Thank you for your passed and continuing help and support. Been taking dasatsnib since 2018 or 2019; with 1 incidence of Pleural effusion/thoracenticis, etc., in 2021. —that’s when I switched to Dr Cortes. zwent from 100mg to 20. For last 2-3 years. Dx’d in 2014. I have CLL and CML simultaneously
tedrog
in
CLL Support
2 months ago
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