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Mast cell leukaemia
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Foundation One heme blood test results
Hi, I wonder if somebody knows about this topic. My platelets have been high for six years; the bone marrow biopsy was incomplete because the nurse could not obtain the solid part. Anyway, the liquid aspiration was analyzed, and the bone marrow looked normal; the next-generation sequencing panel from
Hi, I wonder if somebody knows about this topic. My platelets have been high for six years; the bone marrow biopsy was incomplete because the nurse could not obtain the solid part. Anyway, the liquid aspiration was analyzed, and the bone marrow looked normal; the next-generation sequencing panel from
Cusube1967
in
CLL Support
1 year ago
essential, thrombocythemia transformation
has any one you know had leukemic transformation from having essential turn thrombocythemia
has any one you know had leukemic transformation from having essential turn thrombocythemia
Meeileem
in
MPN Voice
1 year ago
New diagnosis
I have just been diagnosed with CLL via complete blood count. I have not been seen by a haematologist yet (9 May) I an a UK citizen actually living in Spain. Does anyone think or know if taking Vitamin B12 helps.
I have just been diagnosed with CLL via complete blood count. I have not been seen by a haematologist yet (9 May) I an a UK citizen actually living in Spain. Does anyone think or know if taking Vitamin B12 helps.
davjb15121
in
CLL Support
1 year ago
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The Role of New Technologies in Myeloproliferative Neoplasms
I was reviewing some of the items in my bookmarked resources and came across this article from 2019. It was worth a reread. The article is a literature review and has some very interesting references regarding various issues related to MPNs, including information about the three driver mutations.
I was reviewing some of the items in my bookmarked resources and came across this article from 2019. It was worth a reread. The article is a literature review and has some very interesting references regarding various issues related to MPNs, including information about the three driver mutations.
hunter5582
in
MPN Voice
1 year ago
The current status and challenges of CAR-T therapy in CLL
A few members of this group are scheduled for CAR-T and others might find themselves in the same situation in the future so I thought this would be of interest. "[i]In recent years, novel immunotherapies, including CAR-T cell therapy, have greatly improved treatment options for patients with hematological
A few members of this group are scheduled for CAR-T and others might find themselves in the same situation in the future so I thought this would be of interest. "[i]In recent years, novel immunotherapies, including CAR-T cell therapy, have greatly improved treatment options for patients with hematological
Jm954
Administrator
in
CLL Support
1 year ago
Pelabresib in Combination With Ruxolitinib for Myelofibrosis
“To our knowledge, the MANIFEST trial in JAKi treatment-naïve patients is the first study with a rational combination of BETi pelabresib and ruxolitinib that showed clinically meaningful durable improvements in splenomegaly and symptoms, was associated with biomarker findings indicating potential disease
“To our knowledge, the MANIFEST trial in JAKi treatment-naïve patients is the first study with a rational combination of BETi pelabresib and ruxolitinib that showed clinically meaningful durable improvements in splenomegaly and symptoms, was associated with biomarker findings indicating potential disease
Manouche
in
MPN Voice
1 year ago
Help understanding my BMB results
Just an update, I have received my post clinic letter from my consultant and the results of the genetic tests are now in. CALR mutated 9 no deletion- neither type 1 nor type 2 ( probably best described as type 2 like) Post ET MF on bone marrow - CALR, IDH2, TET2 mutation s and no copy number abnormalities
Just an update, I have received my post clinic letter from my consultant and the results of the genetic tests are now in. CALR mutated 9 no deletion- neither type 1 nor type 2 ( probably best described as type 2 like) Post ET MF on bone marrow - CALR, IDH2, TET2 mutation s and no copy number abnormalities
UKZA
in
MPN Voice
1 year ago
Besremi Titration Questions
I am 50yo diagnosed with PV/JAK2+ since 2018. I went through HU and then Jakafi before MPN specialist at Johns Hopkins recommended switching to Besremi for longer term complete blood response. I started Besremi titration Dec 21, 2022 at 100mcg. I have been increasing 50mcg every 2 weeks after CBC checks
I am 50yo diagnosed with PV/JAK2+ since 2018. I went through HU and then Jakafi before MPN specialist at Johns Hopkins recommended switching to Besremi for longer term complete blood response. I started Besremi titration Dec 21, 2022 at 100mcg. I have been increasing 50mcg every 2 weeks after CBC checks
RyanCB
in
MPN Voice
1 year ago
UK NICE Approves Ibrutinib +Venetoclax for First Line treatment for ALL Patients from today
Probably one of the best news stories that we have been able to announce in many years for patients in England and Wales. We are absolutely delighted that this effective treatment is now available for ALL CLL patients as their first treatment if their doctor feels it is appropriate. This treatment
Probably one of the best news stories that we have been able to announce in many years for patients in England and Wales. We are absolutely delighted that this effective treatment is now available for ALL CLL patients as their first treatment if their doctor feels it is appropriate. This treatment
Jm954
Administrator
in
CLL Support
1 year ago
Relapsed CLL: New Approaches Prolong Survival
Dr Furman says that genetically unstable CLL patients need a combination therapy approach to treatment irrespective of MRD assessment results. This is only a short read and Dr Furman's opinion is always worth taking note of. In case it’s behind a paywall, here is the article in full. Credit to
Dr Furman says that genetically unstable CLL patients need a combination therapy approach to treatment irrespective of MRD assessment results. This is only a short read and Dr Furman's opinion is always worth taking note of. In case it’s behind a paywall, here is the article in full. Credit to
Jm954
Administrator
in
CLL Support
1 year ago
Expression of TCL1A gene is found to drive onset of blood cancer
[i]One of the causes of blood cancer is non-inherited mutations in blood stem cells that can lead to the cancerous growth of abnormal cells. Reporting in Nature, scientists now suggest that targeting a gene called TCL1A may be able to suppress such growth and decrease the risk of blood cancer....[/i]
[i]One of the causes of blood cancer is non-inherited mutations in blood stem cells that can lead to the cancerous growth of abnormal cells. Reporting in Nature, scientists now suggest that targeting a gene called TCL1A may be able to suppress such growth and decrease the risk of blood cancer....[/i]
bennevisplace
in
CLL Support
1 year ago
'Astonishing' Results: Skip Salvage Chemo, Go Straight to HSCT from ASH 2022 [For Refractory AML/Relapsed AML]
NEW ORLEANS — Investigators confessed to being "astonished" by results of a randomized trial showing that patients with acute myeloid leukemia who have a poor response following induction therapy do just as well going on to immediate allogeneic transplant as they would if they had received an intensive
NEW ORLEANS — Investigators confessed to being "astonished" by results of a randomized trial showing that patients with acute myeloid leukemia who have a poor response following induction therapy do just as well going on to immediate allogeneic transplant as they would if they had received an intensive
PhysAssist
in
MPN Voice
1 year ago
Strategic Masking to Protect Patients from All Respiratory Viral Infections
https://www.nejm.org/doi/full/10.1056/NEJMp2306223 - The end of the public health emergency in the United States is a richly symbolic milestone in the course of the SARS-CoV-2 pandemic. During the height of the pandemic, the virus killed millions of people worldwide, upended lives, and radically altered
https://www.nejm.org/doi/full/10.1056/NEJMp2306223 - The end of the public health emergency in the United States is a richly symbolic milestone in the course of the SARS-CoV-2 pandemic. During the height of the pandemic, the virus killed millions of people worldwide, upended lives, and radically altered
lankisterguy
Volunteer
in
CLL Support
1 year ago
Spotlight on CLL - Nicole Lamanna, MD Wednesday May 24, 2023 1:00 PM to 2:30 PM EDT- sponsored by LLS- USA but open to all
Unlike other webinars I have posted recently, this should be easy to understand, especially for newly diagnosed and those not familiar with Med-Speak. Dr. Lamanna has a track record of explaining CLL and side effects, with a simple, caring & warm style. - Len - Nicole Lamanna, MD Director, Chronic
Unlike other webinars I have posted recently, this should be easy to understand, especially for newly diagnosed and those not familiar with Med-Speak. Dr. Lamanna has a track record of explaining CLL and side effects, with a simple, caring & warm style. - Len - Nicole Lamanna, MD Director, Chronic
lankisterguy
Volunteer
in
CLL Support
1 year ago
Advances in Chronic Lymphocytic Leukemia: A Master Class for the Community Multidisciplinary Team Open Registration April 27 12:00-1:00PM ET
Advances in Chronic Lymphocytic Leukemia: A Master Class for the Community Multidisciplinary Team Live Simulcast | Register now for this interactive CME/CE/CPE-certified workshop to gain expert insight on current best practices and emerging strategies for advances in chronic lymphocytic leukemia
Advances in Chronic Lymphocytic Leukemia: A Master Class for the Community Multidisciplinary Team Live Simulcast | Register now for this interactive CME/CE/CPE-certified workshop to gain expert insight on current best practices and emerging strategies for advances in chronic lymphocytic leukemia
lankisterguy
Volunteer
in
CLL Support
1 year ago
My chemo experience
I started with fludarabine and rituximab which wasn't great. I had feelings of hot and cold, spots before my eyes, vertigo and blacking out. My haematologist was there in minutes, lowered my dose and I was able to complete the course over 6 hours without further adverse effects. Subsequent treatments
I started with fludarabine and rituximab which wasn't great. I had feelings of hot and cold, spots before my eyes, vertigo and blacking out. My haematologist was there in minutes, lowered my dose and I was able to complete the course over 6 hours without further adverse effects. Subsequent treatments
kiwiCanuck
in
CLL Support
1 year ago
SCT while feeling well
I have been put forward for a SCT, providing a further heart scan is ok. I have Post ET Myelofibrosis, MPL positive, I also have another mutation, which I’ve been told will increase my chances of getting leukaemia. I have pretty much decided I will go through with it, but know it will be very tough.
I have been put forward for a SCT, providing a further heart scan is ok. I have Post ET Myelofibrosis, MPL positive, I also have another mutation, which I’ve been told will increase my chances of getting leukaemia. I have pretty much decided I will go through with it, but know it will be very tough.
SRH55
in
MPN Voice
1 year ago
Interesting
Clinical Review of ropeginterferon alfa-2b Suggests Amended Dosing Schedule May Support Improved Clinical Outcomes in Polycythemia Vera Review of studies published in Frontiers in Oncology highlights dosing considerations that may help more patients achieve earlier complete hematological response
Clinical Review of ropeginterferon alfa-2b Suggests Amended Dosing Schedule May Support Improved Clinical Outcomes in Polycythemia Vera Review of studies published in Frontiers in Oncology highlights dosing considerations that may help more patients achieve earlier complete hematological response
wateron
in
MPN Voice
1 year ago
New and Emerging Treatments for Newly Diagnosed and R/R CLL/SLL: Targeted Inhibitors - Dr. Susan O'Brien
This webcast on new and emerging treatments for newly diagnosed and R/R CLL/SLL with a focus on targeted inhibitors, presented by Dr. Susan O'Brien is intended for medical professionals and uses moderate "Med-Speak." So only recommended for those accustomed to the medical language. But if you can follow
This webcast on new and emerging treatments for newly diagnosed and R/R CLL/SLL with a focus on targeted inhibitors, presented by Dr. Susan O'Brien is intended for medical professionals and uses moderate "Med-Speak." So only recommended for those accustomed to the medical language. But if you can follow
lankisterguy
Volunteer
in
CLL Support
1 year ago
Essential Thrombocythaemia and Pneumococcal vaccine safe to take?
hello my husband is 36 with Essential Thrombocythaemia Calr type 1 and on aspirin only he has received a letter for the Pneumococcal vaccine but I’m wondering is it safe to take with having ET?
hello my husband is 36 with Essential Thrombocythaemia Calr type 1 and on aspirin only he has received a letter for the Pneumococcal vaccine but I’m wondering is it safe to take with having ET?
Green1988
in
MPN Voice
1 year ago
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