Lorazepam and levodopa interaction

[Daisies22]

I certainly was not aware of that until my levodopa stopped working.

I wonder why a Neurologist would not inform his patients with Parkinson's about such a serious drug interaction.

drugs.com

LORazepam can decrease the effects of levodopa in some people. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your Parkinson symptoms worsen.

[park_bear]

Good catch!

[LAJ12345]

and if that does other similar drugs might do too.

My husband uses clonazapam and finds it is one of the only things that helps. Maybe because it reduces the effects/ side effects of the levodopa

ChatGPT:

Lorazepam belongs to a class of drugs known as benzodiazepines, which are commonly used to treat anxiety, insomnia, and seizures due to their sedative, muscle-relaxant, and anticonvulsant effects. Benzodiazepines enhance the effect of the neurotransmitter GABA (gamma-aminobutyric acid), producing calming effects.

Here are some other commonly used benzodiazepines that are similar to lorazepam:

1. Diazepam (Valium)

Use: Often prescribed for anxiety, muscle spasms, and alcohol withdrawal.

Duration: Long-acting, with effects lasting up to 24 hours.

Differences: Diazepam is longer-lasting than lorazepam and is often used in situations where longer sedation or anxiety relief is needed.

2. Alprazolam (Xanax)

Use: Commonly prescribed for anxiety and panic disorders.

Duration: Shorter-acting than lorazepam, but with a rapid onset.

Differences: It is more likely to be prescribed for panic disorders due to its fast-acting effects.

3. Clonazepam (Klonopin)

Use: Used for panic disorders, anxiety, and seizure disorders.

Duration: Long-acting, providing relief for 8-12 hours.

Differences: Similar to lorazepam but has a longer duration and is often preferred for seizure disorders.

4. Temazepam (Restoril)

Use: Primarily prescribed for insomnia.

Duration: Short to intermediate duration.

Differences: Often used for sleep issues rather than anxiety or panic attacks.

5. Midazolam (Versed)

Use: Used in sedation for medical procedures and short-term anxiety relief.

Duration: Short-acting, with rapid onset.

Differences: Commonly used in hospital settings for preoperative sedation.

6. Clorazepate (Tranxene)

Use: Treats anxiety, alcohol withdrawal, and seizures.

Duration: Long-acting.

Differences: Has a slower onset compared to lorazepam but lasts longer.

7. Oxazepam (Serax)

Use: Often prescribed for short-term anxiety and alcohol withdrawal.

Duration: Short to intermediate acting.

Differences: Metabolized more slowly, making it a gentler option for older adults or those with liver issues.

All of these drugs work similarly by enhancing GABA’s calming effects on the nervous system, but they vary in terms of onset, duration, and specific medical applications.

It’s important to note that benzodiazepines can lead to dependency, and long-term use should be carefully monitored by a healthcare provider. Always consult with a healthcare professional before considering any medication changes.

[Daisies22 in reply to LAJ12345]

Hi and thanks for sharing the information the ChatGPT collected. I didn't know that so many ''variations" of diazepam existed! I am also surprised that they are so long lasting.

Unfortunately, the few I've tried never really had a positive effect on me so I never felt the need to use them.

Glad that some of the benzos help some people.

Best wishes to you and your husband.

[Ghmac]

I was told by a pharmacist that drug interaction/reactions would automatically get a red flag when prescribed. Apparently this program isn't working well.