Experiences with

Jevtana

So my father has now finished 3 rounds of Jevtana and carboplatin. His PSA has only gone up 1-2 points over the last 3 infusions, but today it went up 3 points. Not much compared to The doubling time before but I’m Still concerned if chemo is working or not.

He was on his 3 rd treatment of carbo/Jevtana. Following the treatment his WBC dropped to 0.08 and platelets to 11,000 then to 1,000, went into septic shock from acquiring an infection in his gut. My dad was diagnosed at 65 yrs old in 2011.

Not the news we were praying for😕 my fathers CT scan after 3 rounds of Jevtana and carboplatin to treat NEPC in the lymph nodes, we were hoping that the scans show shrinkage of nodes. Instead the CT scan showed multiple Mets to spine and pelvic bones(all new).

My husband has completed five Jevtana treatments and had a CT and bone scan yesterday. The dr. called this morning to tell us the chemo is not working on his liver cancer. Has anyone else experienced this? I am curious about what the next treatment might be.

My bloods are doing well and my PSA is stable at around 3.5 and I have been off Chemo-Jevtana for nine months.

He suggested that my Dad be placed on another round of chemo - Jevtana. My Dad is in his early 80s. Since the last Chemo in April 2017, my Dad has been on Physical Therapy and he is getting stronger and stronger. He starts Jevtana with Prednisone on March 2nd.

Tried Taxotere, then Jevtana, and was on carbo/Jevtana till he passed. We went to Sloan Kettering, Dana Farber, and Mass General. I had him all over! He was also transfusion dependent receiving weekly transfusions for over a year and a half. That’s about 100 blood transfusions.

So my father just had his third round of Jevtana and carboplatin. We are all highly suspicious that the chemo is not working. It is keeping his PSA stable but the chromogranin A continues to rise. Although he is at the CITY OF HOPE it seems that the CAR-T treatment is still awaiting IRB.

Jevtana is now showing signs of not working my psa just went up again this time from 32 to 36 i just took cycle 22, one every three weeks. this is the last good option i am being told by my cancer , Oncologist i figure i will be off of Jvetana soon and everything beyond that is a roll of the dice. so

After 1st cycle Of Jevtana and carboplatin we were really hoping to see some significant-drop in PSA and CGa. His PSA went from 16.4 to 17.2 a very minor increase. Is this a normal flare? Is chemo even working? What’s the next step if it doesn’t?

Doug is currently on his third round of chemo (Jevtana) and just finished the fifth of six treatments. Starting to feel like we are running out of option treatments and are hopefully for a longer remission time between treatments this go round.

Starting Jevtana (cabazitaxel) + carboplatin chemo next week and wondering if anyone here has any words of wisdom?

He failed Xtandi (3mo absolutely no changes) and now was recommended to start Jevtana and carboplatin. He has so far had chemo #1. As I was doing some research Today I recall Dr.Kwan explaining that it does not have the “small cell pattern” but definitely looks like Neuroendocrine involvement.

In the waiting room now for his first infusion. My nerves are a 10/10 I am so afraid, worried scared.. all these emotions. Listening to the scary side effects.. worried about rare reactions. Any experiences with these please let me know. It might help me calm my nerves!!!! Thank you all wish us luck

This week, he starts Jevtana which I hope he can tolerate. He still suffers with some neuropathy in both hands and feet. Recently, he's been complaining about a severe headache which he's had almost daily. It does improve if he takes something very strong like hydrocodone.

Kwon’s recommendations except she said it would be better to begin with Jevtana instead of Docetaxel. As i was looking through many of the posts and reading the responses from others i noticed that fasting and chemo is a good idea. And interestingly Dr.

Jevtana is a taxane (as is Taxotere), & was approved by the FDA for men with CRPC in 2010. Typically, in castrate-resistant PCa [CRPC], the cancer remains androgen-sensitive & has found alternative sources.

[XC] Cabazitaxel [Jevtana] [XC1] "Cabazitaxel showed significantly higher cytotoxic efficacy than docetaxel in human CRPC cells, accompanied by elevated ROS production" "To investigate whether cabazitaxel-mediated cell death was caused by the ROS generation induced by cabazitaxel, we treated CRPC cells

(we are currently at U of Chicago) Our oncologist recommends starting Jevtana-carboplatin chemo ASAP - in 2 days and says success rate is (only) 33%. Has any else been down this road?

The study enrolled 50 patients who were no longer responding to standard treatments, including docetaxel (Taxotere), abiraterone acetate (Zytiga), enzalutamide (Xtandi), or cabazitaxel (Jevtana). Genomic sequencing was performed on tumor biopsies as a requirement of the study.