Actinium shortage - oh no!!!

[HopingForTheBest1]

Just when I was about to start a promising new trial using 225Ac-J591, along with Keytruda + Enzalutamide -

“While early clinical results from actinium-225-based radiopharmaceuticals have been promising, the extreme global shortage of actinium-225 has slowed research and development activities and made commercialization of an actinium-225-based radiopharmaceutical very challenging,” said Dr. Joe McCann, CEO of POINT Biopharma.

I haven't been told yet that the trial will be delayed. I sure hope not. Time is not really on my side.

[lewicki]

It seems that AC-225 is even a shortage at the university of Heidelberg since they only offer it every other month. Was like this when I went in July 2020 and earlier.

[NWLiving]

Ohhhh. Well that’s quite a way to muck up plans and hopes for the summer and beyond. Words cannot express the frustration. How are you feeling physically now?

[HopingForTheBest1 in reply to NWLiving]

Physically ok. Mentally freaking out.

[NWLiving]

Whew for today. But mentally, of course. Who even knew that we had to be worried about an actinium-225 shortage? I wonder if Iran, Pakistan or North Korea have any. We could trade for some vaccine. Haha. 🤞 for a source and the trial is not delayed long.

[Hotrod65]

I have scNEPC differentiation that after Foundation Medicine Genomic Sequencing indicated that although i have no qualified Tumor markers for Prostate Cancer i do have a Hypermutated Tumor burden TMB, that was a match for 2 immunotherapy Checkpoint inhibitors..i have had 50 infusions over past 6 years and recently the first of 2 annual maintainence doses going forward..im considered a rare "Exceptional Responder"and owe my life to Pembrilizimab, i had no options left at the time when told 3-6 months left..it works for some but not for all..i wish i could be more uplifting for you but sounds like you had Sequencing done already there is some very promising combo therapies that include Keytruda as an agent.i wish you much success..stay strong Brother.

[HopingForTheBest1 in reply to Hotrod65]

I am expecting to start a triple therapy of 225Ac-J591 + Keytruda + Enzalutamide at Weill Cornell. You have had 50 infusions of Pembrolizumab/Keytruda, and will you continue them since it is effective for you?

[addicted2cycling in reply to HopingForTheBest1]

Not meaning to step into a conversation where I "technically" have little knowledge, but just wondering if the following information could provide an alternate path >>>

immunsys.com/

If I am breaking rules or offending, please have deleted.

p.s. -- in 2015 I chose to have a triple combo non-FDA approved injection of Opdivo+Keytruda+Yervoy as part of my treatment by Dr. Onik for my GL10

Best of luck HFTB1

[HopingForTheBest1 in reply to addicted2cycling]

Thanks for your info. I will investigate further.

[HopingForTheBest1 in reply to addicted2cycling]

After your treatment in 2015, what have you done since?

[addicted2cycling in reply to HopingForTheBest1]

HopingForTheBest1 wrote --- "After your treatment in 2015, what have you done since?"

Diet + Exercise + hope for the best.

In 2018 a minor return of GL6/7 in left half of remaining prostate required treating(right side was clear) and just hanging in checking numbers every 3 months. I have been a committed pessimist for decades always expecting the worse and as such have prepared for the return of my PCa or something else to present another pothole to avoid as I bicycle through my "journey of life." STRESSING OUT on what might be/what if does no good for me mentally or physically so I just "tune out those thoughts."

How are you making out?

BTW, just as an example of how a POT-HOLE APPEARS >> tomorrow is my 71st BIRTHDAY. For years I've done a Birthday Bicycle Ride that most riders bicycle a distance of one's age in miles or km. For years I have DOUBLED my age and added one extra mile for good measure so this year it's a 143 mile ride. Last Sunday I had a little crash on my bicycle 2 miles from home at mile 100. Thankfully the X-rays showed no broken bones BUT THE PAIN REMAINS. Now MY Birthday Ride distance is in jeopardy so I will simply head out at 12:01AM tomorrow and ride until I drop.

[Fuzzman77]

Try Dr. Ishita Sen with Fortis? That’s in Delhi. I’d at least ask her about it.

[MateoBeach]

Here is the story on Ac225 production. Currently being ramped up.

isotopes.gov/information/ac...

[HopingForTheBest1]

When I click on the link it says Page Not Found.