Hexose-6-phosphate dehydrogenase blockade reverses enzalutamide resistance

[SimonHL]

New Paper:

“Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation”

stm.sciencemag.org/content/...

[Shooter1]

Enzalutamide failing for me now... too bad the drugs they are dreaming of developing won't be available soon enough for me... Research will continue and in 10 years Xtandi may last many years in treatment. Just hope for those who follow.....

[MateoBeach in reply to Shooter1]

BAT can restore enzalutamide response in many if you are appropriate for that. Docetaxel chemo also, to some degree.

[Shooter1 in reply to MateoBeach]

Heavy duty neuropathy from last round of docetaxel. Don't want to loose use of my toes again, but thanks for info. .

[Spyder54]

One more piece in the puzzle. This piece buys us more time. More time for some of the latest immuno therapies that are finally working to make it thru Phase III Trials keeping us alive for that day.

[Shooter1 in reply to Spyder54]

Life is good. I would like to take grandkids fishing etc.

[Spyder54 in reply to Shooter1]

Love your attitude Shooter! Im tryng to live long enough to see some grandchildren. The kids wait too long.

[Shooter1]

Injectable T for BAT my work. Looks like maybe 40% of people respond. Do you have info showing more>??>

[Shooter1]

No such luck there. Just got test results back showing complete mutation load of 0.48% from my CTC and no actionable mutations. Just regular un-mutated aPca that has learned to like enzalutamide environment.

[Shooter1]

Most anything is worth a try when options start to thin out.

[Spyder54 in reply to Shooter1]

Shooter, you should listen to the BAT suggestion from Mateo Beach and Nalakrats above. Those dudes are some of the smartest here, and both have strong medical backgrounds. Extend your fishing license for another 5 years 🍾👍