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2019 Top Stories in Advanced Prostate Cancer: Cabazitaxel vs Abiraterone or Enzalutamide in Metastatic Prostate Cancer
) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie, abiraterone or
enzalutamide
).
) in men who had previously been treated with docetaxel or the other androgen signaling–targeted inhibitor (ie, abiraterone or
enzalutamide
).
Balsam01
in
Advanced Prostate Cancer
5 years ago
Antitumor Activity Seen With Keytruda in mCRPC
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both
enzalutamide
(Xtandi) and abiraterone (Zytiga).
In the study, 29% of patients had previously undergone two or more chemotherapy regimens, and about 25% were treated with both
enzalutamide
(Xtandi) and abiraterone (Zytiga).
snoraste
in
Advanced Prostate Cancer
5 years ago
BAT failed after 2 years
The JH trials show that BAT re sensitises PCa to
enzalutamide
(Enza) and abiraterone (Abi). My experience is that it does likewise for bicalutamide. When I become resistant to a 2nd generation antiandrogen I will certainly consider reusing BAT. By then we will know more about it.
The JH trials show that BAT re sensitises PCa to
enzalutamide
(Enza) and abiraterone (Abi). My experience is that it does likewise for bicalutamide. When I become resistant to a 2nd generation antiandrogen I will certainly consider reusing BAT. By then we will know more about it.
kaptank
in
Advanced Prostate Cancer
5 years ago
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Veyonda (idronoxil). For enhancing radiation effects and launching abscopal immune response. DARRT Trials and LuPIN Trial
LuPIN-1 trial of Veyonda with Lu-PSMA-617 in mCRPC (Australia) LuPIN-1 is a dose escalation and dose expansion trial of men with mCRPC progressing despite having received docetaxel, cabazitaxel and either abiraterone or
enzalutamide
.
LuPIN-1 trial of Veyonda with Lu-PSMA-617 in mCRPC (Australia) LuPIN-1 is a dose escalation and dose expansion trial of men with mCRPC progressing despite having received docetaxel, cabazitaxel and either abiraterone or
enzalutamide
.
MateoBeach
in
Advanced Prostate Cancer
5 years ago
Indirect Comparisons of Efficacy Between Combination Approaches in Metastatic Hormone-Sensitive Prostate Cancer
In all, seven trials met eligibility criteria using either docetaxel, abiraterone acetate,
enzalutamide
, or apalutamide in combination with ADT.
In all, seven trials met eligibility criteria using either docetaxel, abiraterone acetate,
enzalutamide
, or apalutamide in combination with ADT.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Testosterone & Docetaxel in CRPC.
KEYWORDS: abiraterone; androgen receptor; chemotherapy;
enzalutamide
; prostate-specific antigen PMID: 31816126 DOI: 10.1002/pros.23938
KEYWORDS: abiraterone; androgen receptor; chemotherapy;
enzalutamide
; prostate-specific antigen PMID: 31816126 DOI: 10.1002/pros.23938
pjoshea13
in
Advanced Prostate Cancer
5 years ago
New, Non-hormonal Target Identified for Advanced Prostate Cancer
Huang’s research team tested the drug, navarixin, in laboratory and animal studies, demonstrating that it killed hormone-resistant tumors in combination with
enzalutamide
, where
enzalutamide
failed on its own.
Huang’s research team tested the drug, navarixin, in laboratory and animal studies, demonstrating that it killed hormone-resistant tumors in combination with
enzalutamide
, where
enzalutamide
failed on its own.
DrWrite
in
Advanced Prostate Cancer
5 years ago
Survival With Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer in Clinical Practice
All had prior docetaxel, and 82% prior abiraterone,
enzalutamide
or both. Median duration of cabazitaxel treatment was 3.4 months. Median OS from cabazitaxel initiation was 11.9 months [95% CI: 10.1-12.9].
All had prior docetaxel, and 82% prior abiraterone,
enzalutamide
or both. Median duration of cabazitaxel treatment was 3.4 months. Median OS from cabazitaxel initiation was 11.9 months [95% CI: 10.1-12.9].
Balsam01
in
Advanced Prostate Cancer
5 years ago
Best new drugs for castrate-resistant PC?
I'm looking at new drugs; most-mentioned are abiraterone,
enzalutamide
, and apalutamide (while continuing ADT) -- or some combination. I'd much appreciate advice from those who have tried these. Or maybe I should try one of the others mentioned in your Posts? Many thanks, Yeatz
I'm looking at new drugs; most-mentioned are abiraterone,
enzalutamide
, and apalutamide (while continuing ADT) -- or some combination. I'd much appreciate advice from those who have tried these. Or maybe I should try one of the others mentioned in your Posts? Many thanks, Yeatz
yeatz
in
Advanced Prostate Cancer
5 years ago
ASCO GU 2020: Additional Mechanism of Action of PARP Inhibitor Talazoparib Attacks Prostate Cancer Cells, Spares Normal Cells
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (
enzalutamide
/abiraterone acetate).
Participants have received one to two chemotherapy regimens (at least one taxane-based) and progressed on at least one novel hormone therapy (
enzalutamide
/abiraterone acetate).
Balsam01
in
Advanced Prostate Cancer
5 years ago
Luteolin & Androgen Receptor splice variant 7 [AR-V7].
MiR-8080 induced by luteolin intake enhanced the therapeutic effect of
enzalutamide
on 22Rv1 xenografts under castration conditions.
MiR-8080 induced by luteolin intake enhanced the therapeutic effect of
enzalutamide
on 22Rv1 xenografts under castration conditions.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
William K. Oh, MD [Mount Sinai] & ENZAMET
v=Ey7Pn-aamMg ENZAMET [1] compared "ADT" +
Enzalutamide
with ADT + an older antiandrogen in newly diagnosed metastatic PCa. The Enza combo worked better. However, some men opted to also have chemo, & the benefit of Enza was not seen in those men.
v=Ey7Pn-aamMg ENZAMET [1] compared "ADT" +
Enzalutamide
with ADT + an older antiandrogen in newly diagnosed metastatic PCa. The Enza combo worked better. However, some men opted to also have chemo, & the benefit of Enza was not seen in those men.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Have question about drug Talazoparib.
Or info or involvement in trial using
Enzalutamide
and Talazoparib?
Or info or involvement in trial using
Enzalutamide
and Talazoparib?
Parscore
in
Advanced Prostate Cancer
5 years ago
Lutamides
My current MO has recommended I start
enzalutamide
(Xtandi). My pending MO prefers darolutamide. Has anyone studied the literature to determine if there is any comparative information on these drugs, as well as apalutamide. Also I’m interested in experience with any of the drugs.
My current MO has recommended I start
enzalutamide
(Xtandi). My pending MO prefers darolutamide. Has anyone studied the literature to determine if there is any comparative information on these drugs, as well as apalutamide. Also I’m interested in experience with any of the drugs.
Twoofus
in
Advanced Prostate Cancer
5 years ago
SBRT successful
Treatment with
enzalutamide
must wait. So if you are in my situation, I recommend you that you ask for a SBRT to your oncologist. Regards J.R.P.
Treatment with
enzalutamide
must wait. So if you are in my situation, I recommend you that you ask for a SBRT to your oncologist. Regards J.R.P.
jrodrig
in
Advanced Prostate Cancer
5 years ago
Criteria for Commencement of Next Line Therapy
I am having difficulty finding papers that compared the outcomes of therapies, such as chemotherapy, abiraterone,
enzalutamide
or SBRT, which were started late vs early. If any member is aware of published literature describing the aforementioned, it would be greatly appreciated.
I am having difficulty finding papers that compared the outcomes of therapies, such as chemotherapy, abiraterone,
enzalutamide
or SBRT, which were started late vs early. If any member is aware of published literature describing the aforementioned, it would be greatly appreciated.
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
Minor but steady rise in PCA, recurrence?
Post chemo, salvage radiation, prostatectomy and currently on 4 tabs
enzalutamide
daily,zoledronic 3 monthly, eligard 6 monthly. The PSA seems to be rising <.01, .01,.013,.02 and now .03 in consecutive months. Doctor has asked to monitor another two months and then go for psma pet scan.
Post chemo, salvage radiation, prostatectomy and currently on 4 tabs
enzalutamide
daily,zoledronic 3 monthly, eligard 6 monthly. The PSA seems to be rising <.01, .01,.013,.02 and now .03 in consecutive months. Doctor has asked to monitor another two months and then go for psma pet scan.
caretkr
in
Advanced Prostate Cancer
5 years ago
Docetaxel Improves Survival in Metastatic Hormone-Naïve Prostate Cancer
This implies some degree of cross-resistance between
enzalutamide
and docetaxel with regard to prolongation of survival, and that either of these agents may be effective—but not a triplet with ADT, docetaxel, and
enzalutamide
.
This implies some degree of cross-resistance between
enzalutamide
and docetaxel with regard to prolongation of survival, and that either of these agents may be effective—but not a triplet with ADT, docetaxel, and
enzalutamide
.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Zytiga vs xtandi
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate or
enzalutamide
.
211 patients with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone acetate or
enzalutamide
.
Magnus1964
in
Advanced Prostate Cancer
5 years ago
Home in Hawaii.
Found this: https://www.urologytimes.com/aua-annual-meeting/
enzalutamide
-vs-abiraterone-survival-care-costs-compared Mele Kalikimaka Mahalo Randy
Found this: https://www.urologytimes.com/aua-annual-meeting/
enzalutamide
-vs-abiraterone-survival-care-costs-compared Mele Kalikimaka Mahalo Randy
dockam
in
Advanced Prostate Cancer
5 years ago
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