Enzalutamide Extends Radiographic PFS in Metastatic Hormone-Sensitive Prostate Cancer

[6357axbz]

ascopost.com/issues/april-1...

[NPfisherman]

Thanks for posting this information...let the medical science keep rolling...

Fish

[AZjame in reply to NPfisherman]

Yes, thanks for posting these important interim results!

[6357axbz in reply to NPfisherman]

Now the question for me is which promises to be more effective for mHSPCa, Abiraterone/prednisone or Enzalutamide? I asked this in another post but so far no definitive responses.

[NPfisherman in reply to 6357axbz]

Great question....just happy that both exist...my MO chose abiraterone post STAMPEDE for me...so far....amongst the "undetectables"...watching the science daily and hoping....there are non-PCa drugs coming which will cross over...RRx-001 is one I watch...bempedoic acid is another...let the science roll and kill the beast..

Don Pescado

[Sherpa111 in reply to NPfisherman]

Same with me, Mr. Fish.

[EdBar in reply to 6357axbz]

For me, Xtandi has been doing the trick. Snuffy Myers started me on Xtandi about four and a half years ago even though I was still hormone sensitive, currently PSA remains undetectable and scans are clear of active mets.

I recently had a visit with Dr. Sartor who said he has had some patients go as long as 7-8 years before Xtandi lost its effectiveness, I’m hoping to beat that. Meanwhile just taking it a day at a time.

Ed

[Break60 in reply to EdBar]

Ed

What was your situation when you went in xtandi?

[EdBar in reply to Break60]

I was dx Stage 4 G9 mets throughout skeleton and in several nodes. When I started seeing Snuffy I was already being treated with Lupron, Casodex, and Avodart. He switched the Casodex to Xtandi. If I recall my PSA at the time was at or near undetectable but mets were still showing up on scans but getting smaller. Snuffy had the “hit it hard early” approach which I agreed with. I also had my prostate and several nodes radiated early on and chemo per CHAARTED. Threw the kitchen sink at it!

Ed

[Break60 in reply to EdBar]

Thanks. I haven’t started the second generation adt meds because I’m doing so well on estradiol . I’ve never had more than two bone mets. Ive followed the axiom “ if it ain’t broke don’t fix it”. I feel good and don’t want the side effects of new treatments unless it’s absolutely necessary.

Bob

[EdBar in reply to Break60]

Can’t blame you there, they do come with a lot of side effects.

[rococo]

Seem like big pharma wants to move these drugs up to earlier stage before they go generic which may be a good thing. Too early for overall surviva rates. Rocco

[monte1111]

Great article since I've been taking Xtandi almost 21 months. But, I am confused, as usual. I started with 59.5 Psa, extensive bone mets, lymph node mets. After lupron, chemo, Xtandi psa has steadily declined to 0.1 Does that make me hormone sensitive metastatic prostate cancer? And if so, does that mean my MO has been giving me Xtandi "off label". Only approved for castrate resistant metastatic prostate cancer? As I say. I am confused.

[NPfisherman in reply to monte1111]

I am confused every day....LOL.... I blame Lupron !!!

Fish

[Sherpa111 in reply to NPfisherman]

So true. Now Why did I log into this site??

[NPfisherman in reply to Sherpa111]

Love it !!! Indeed... why am I here?? I know...because our Administrator needs someone's replies to TA to delete... War over peace... Have a great day !!!

Fish

[j-o-h-n in reply to NPfisherman]

youtube.com/watch?v=ftE8vr0...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 05/08/2019 8:10 PM DST

[NPfisherman in reply to j-o-h-n]

Fabulous....but played to the wrong crowd..sadly...but on a different topic....How you been doing, my Consiglieri de Umorismo...??

Fish

[j-o-h-n in reply to NPfisherman]

Inasmuch as I want to respond to you in Italian... I can't my hands are tied...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 05/08/2019 9:33 PM DST

[NPfisherman in reply to j-o-h-n]

You doin' something kinky again with Dolly...Dang, homey... You and that air bag are wack, slick...

Don Pescado the alias Fish

[j-o-h-n in reply to NPfisherman]

j-o-h-n <==== giggling in Italian....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 05/08/2019 9:41 PM DST