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Enzalutamide
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Abiraterone/enzalutamide+PARP inhibitor better than abiraterone/enzalutamide alone for mCRPC, even without BRCA+
By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or
enzalutamide
, cancer progression was slowed, even in men who were BRCA-.
By combining the PARP inhibitor (Lynparza (olaparib) or Talzenna (talazoparib)) with either abiraterone or
enzalutamide
, cancer progression was slowed, even in men who were BRCA-.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Small molecule ACK1 inhibitor (R)-9b - third generation AR receptor - clinical trial I in 2023
We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome
Enzalutamide
and abiraterone-resistant prostate cancer.
We have identified (R)-9b as a `third generation' of AR-antagonist, which has ability to overcome
Enzalutamide
and abiraterone-resistant prostate cancer.
Hidden
in
Advanced Prostate Cancer
2 years ago
Proteolysis Targeting Chimeras
"[i]The compounds ... significantly inhibit
enzalutamide
-resistant growth of castration resistant prostate cancer (CRPC) cells.
"[i]The compounds ... significantly inhibit
enzalutamide
-resistant growth of castration resistant prostate cancer (CRPC) cells.
pjoshea13
in
Fight Prostate Cancer
2 years ago
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Re engagement of Enzalutamide in the UK?
Ahead of an oncology appointment, I was wondering if anyone had had positive experience of this, especially in the UK? I have a feeling it is rarely entertained. There is little doubt this drug made the most difference in regressing my cancer but I was taken off it when my PSA started to rise. Despite
Ahead of an oncology appointment, I was wondering if anyone had had positive experience of this, especially in the UK? I have a feeling it is rarely entertained. There is little doubt this drug made the most difference in regressing my cancer but I was taken off it when my PSA started to rise. Despite
Finlay66
in
Advanced Prostate Cancer
2 years ago
looking for recommendations,other options, last advice we got from a doc...nubeqa isn't working but let's keep doing it
-rising PSA and declining urinary function 1/2021,
enzalutamide
instituted with excellent initial PSA response but cognitive decline necessitating 50% dose reduction. PSA rising late 2021.
-rising PSA and declining urinary function 1/2021,
enzalutamide
instituted with excellent initial PSA response but cognitive decline necessitating 50% dose reduction. PSA rising late 2021.
Spring15-3
in
Prostate Cancer Network
2 years ago
Enzalutamide induced non-ischemic cardiomyopathy. Case report & review of literature on anti-androgen therapy-related cardiovascular events
This is a one-off case, but I wanted to share, just to help those of you on
Enzalutamide
, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
This is a one-off case, but I wanted to share, just to help those of you on
Enzalutamide
, to be aware that this is possible: https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-023-00160-7
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
Is Simvastatin more effective than the other statins, against PCa?
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
In castration-resistant LNCaPabl cells,
enzalutamide
combined with atorvastatin resulted in the most prominent growth inhibition. Notably, simvastatin and also rosuvastatin were able to increase the effect of
enzalutamide
in 22Rv1 cells.
GeorgeGlass
in
Advanced Prostate Cancer
2 years ago
FYI: New data on progression of visceral mets without PSA progression (discordance) and ARAT/docetaxel therapy
., abiraterone and
enzalutamide
) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
., abiraterone and
enzalutamide
) may be susceptible to discordant progression. With the incorporation of early ARAT in SOC, we may see this number rise.
SeosamhM
in
Advanced Prostate Cancer
1 year ago
ASCO 23 - Transdermal square-wave testosterone therapy
Upon disease progression, therapy was switched to
Enzalutamide
(Enza) until progression. (This could be repeated again within the 12 month study period.) As with BAT, the men had CRPC & on ADT throughout. For results, see: https://meetings.asco.org/abstracts-presentations/217181
Upon disease progression, therapy was switched to
Enzalutamide
(Enza) until progression. (This could be repeated again within the 12 month study period.) As with BAT, the men had CRPC & on ADT throughout. For results, see: https://meetings.asco.org/abstracts-presentations/217181
pjoshea13
in
Fight Prostate Cancer
2 years ago
Interesting paper summarising state of art (2022) for ADT
From Chapter 7 “All four agents (docetaxel, abiraterone,
enzalutamide
, and apalutamide) have been FDA-approved for the treatment of metastatic, castration-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
From Chapter 7 “All four agents (docetaxel, abiraterone,
enzalutamide
, and apalutamide) have been FDA-approved for the treatment of metastatic, castration-sensitive prostate cancer and are now listed as category 1 recommendations within the NCCN guidelines.81 Treatment choice between agents for metastatic
Graham49
in
Advanced Prostate Cancer
2 years ago
Side effects of Enzalutamide: High blood pressure, Tinnitus & Headaches.
Side effects of
Enzalutamide
: High blood pressure, Tinnitus & Headaches. I have Advance Prostate Cancer Stage 4 with Metastasis to the lymph nodes and bones. Have been on Enza for approx 3 months. I am 66 yrs and living in Malaysia with my wife for the past 25 years.
Side effects of
Enzalutamide
: High blood pressure, Tinnitus & Headaches. I have Advance Prostate Cancer Stage 4 with Metastasis to the lymph nodes and bones. Have been on Enza for approx 3 months. I am 66 yrs and living in Malaysia with my wife for the past 25 years.
barry0405
in
Advanced Prostate Cancer
2 years ago
Genetics - Some answers but not all
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or
enzalutamide
outcome in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2019;25(6):1766–73. https://doi.org/10.1158/1078-0432.CCR-18-1943.
TP53 outperforms other androgen receptor biomarkers to predict abiraterone or
enzalutamide
outcome in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2019;25(6):1766–73. https://doi.org/10.1158/1078-0432.CCR-18-1943.
spw1
in
Advanced Prostate Cancer
2 years ago
Why we add an AART drug to ADT?
So
enzalutamide
or apalutamide used without ADT will increase circulating T while simultaneously blocking it at the AR receptors. This may not apply to darolutamide which does not cross into the brain to reach the hypothalamus.
So
enzalutamide
or apalutamide used without ADT will increase circulating T while simultaneously blocking it at the AR receptors. This may not apply to darolutamide which does not cross into the brain to reach the hypothalamus.
MateoBeach
in
Fight Prostate Cancer
2 years ago
PCa spread to Liver
He is currently on
Enzalutamide
+ hormone injections(monthly) and has had 6 rounds of chemo (Docetaxel) finished in first week of March 2023.
He is currently on
Enzalutamide
+ hormone injections(monthly) and has had 6 rounds of chemo (Docetaxel) finished in first week of March 2023.
A-rat-22
in
Advanced Prostate Cancer
1 year ago
Is Radium223 treatment suitable option for me now
Some participants will get course of Radium223 others will get course of
Enzalutamide
. Just found out I have been assigned to the Radium223 group I have some bone mets (pelvic and L3 area) but no bone pain.
Some participants will get course of Radium223 others will get course of
Enzalutamide
. Just found out I have been assigned to the Radium223 group I have some bone mets (pelvic and L3 area) but no bone pain.
Ronnie7C
in
Advanced Prostate Cancer
2 years ago
Xtandi.....(enzalutamide tablets)
I have received my medication, and it is Xtandi, not Erleada which I thought it would be from the brochure I received from the physician.....Anyone using this stuff.....and if you will.....what's the "scoop" on this stuff..........thanks......I will start this in early May
I have received my medication, and it is Xtandi, not Erleada which I thought it would be from the brochure I received from the physician.....Anyone using this stuff.....and if you will.....what's the "scoop" on this stuff..........thanks......I will start this in early May
eddieboy52
in
Advanced Prostate Cancer
1 year ago
Xtandi (enzalutamide) +ADT slows metastases in recurrent men
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html Early treatment with either may allow extended ADT vacations.
https://www.prostatecancer.news/2023/05/xtandi-
enzalutamide
-adt-slows.html Early treatment with either may allow extended ADT vacations.
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy
"Furthermore, targeting MAOA can disrupt the crosstalk between MAOA and the androgen receptor (AR)
to restore
sensitivity, blocks glucocorticoid receptor (GR)- and AR-dependent PCa cell growth, and is a potential strategy for immune checkpoint inhibition, thereby alleviating immune
"Furthermore, targeting MAOA can disrupt the crosstalk between MAOA and the androgen receptor (AR)
to restore
sensitivity, blocks glucocorticoid receptor (GR)- and AR-dependent PCa cell growth, and is a potential strategy for immune checkpoint inhibition, thereby alleviating immune
pjoshea13
in
Fight Prostate Cancer
1 year ago
I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405
in
Advanced Prostate Cancer
2 years ago
I've Prostate Cancer Stage 4 Mets to lymph nodes & bones. On Hormonal Trmt Enzalutamide. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
On Hormonal Trmt
Enzalutamide
. Has anyone undergo Prostactomy Da Vinci Surgery?
barry0405
in
Advanced Prostate Cancer
2 years ago
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