Experiences with

Dopamine

Effectiveness of each method and how it compares. What about side effects? Which one is less harmful?

There has been some damage to my brain in that it is under functioning/over functioning in the dopamine department and sending messages to various nerve centers. This is totally a layman's explanation but you get the gest . So after a sleep study I will be on Opiates to help get off the ropinirole.

This prompts the release of a hormone called dopamine. Dopamine is called the "feel good" hormone because it causes pleasurable sensations in the brain. The sense of well-being that washes over smokers after taking a puff or two off a cigarette is due to dopamine.

People with Parkinson ’s have a different microbiota than people who don’t have it." "...an undergraduate student who was part of an honors program here at the University of Alabama, Courtney Walker was studying the substantia nigra, which is a region of the brain that contains dopamine neurons.

The substantia nigra, a region of the brainstem that produces dopamine, does not function as it should in PD, resulting in low levels of active dopamine. Studies have shown that the fall in overall dopamine levels begins years before the onset of PD symptoms.

I found in the web an interesting info about a disclaimer contained in the package insert of Sinemet distributed in Australia. It warns as a “side effect the on/off periods may occur to some people after one year use where people may lose their ability to move from minutes to hours then can move again

https://www.fightingparkinsonsdrugfree.com/2019/09/13/fighting-parkinsons-and-your-dopamine-is-not-depleted/

I’m on a dopamine prohibitor and nothing has helped tonight. Currently I have Dysphasia ( due to a auto immune disease) I can’t eat anything that requires a lot of chewing or has to be super soft and covered in a sauce. Like pasta. . Soup. Jello . Ect. A lot of Meat is out of the question .

https://parkinsonsnewstoday.com/2019/09/17/resistant-tremors-arise-outside-brains-dopaminergic-system/

It is to see how much dopamine there is in the brain. Has anyone else had this done ?? She couldn’t say if the findings would help so he is sceptical about having it done.

Background: Parkinson’s disease (PD) involves motor and non-motor symptoms and loss of brain dopamine neurons. Nilotinib is a brain-penetrant tyrosine kinase inhibitor that may alter brain dopamine metabolism.

https://www.nature.com/articles/s41598-019-49876-6

Just over a month tapering off the miaows and a bit of sinemet. Last night, none and had a dreadful night, as most of the others were too. I knew I was in for a tough time, from all of you here, but it was worse. Really no sleep for the duration. I was on mirapex 0.75 daily, and gradually needed the

"E. faecalis was the only strain of bacteria to eat ALL the L-dopa EVERY TIME converting it to dopamine in the gut" https://www.google.com/amp/s/amp.iflscience.com/health-and-medicine/gut-bacteria-may-be-eating-our-medication-and-making-it-ineffective-study-suggests-/ And there seems to be a molecule

For example, are there supplements or things to take or do that help reduce dopamine reduction over time, etc.? Any advice? TIA!

The finding is puzzling because the usual dyskinesias in Parkinson’s are thought to be a result of dopamine action, not serotonin.

Also, I hadn’t responded to dopamine treatment. He then told me it was FND, referred me to a website, neurosymptoms.org, and that was about it! I'm happy (if) it's not PD, but my tremor is stronger than ever.

Ive read somewhere on here that compulsive eating and weight gain is a side effect of any medication with dopamine in. I am on Pramipexole and have been for years and it works for me.

According to the new study, the mechanism of this recalibration is immune-mediated disruption of the dopamine pathway, reducing dopamine release." https://www.news-medical.net/news/20190605/Chronic-inflammation-removes-motivation-by-reducing-dopamine-in-the-brain.aspx?

Modopar , sinemet etc...The supplementation in dopamine seems to be the only response to P.D for most neurologists in France . This website relates new approaches but it seems that the sale of synthetic dopamine is a precious market!!