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Docetaxel
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HSD3B1 Genotype in Metastatic Castration-Sensitive Prostate Cancer
There was no interaction between genotype and benefit from
docetaxel
.
There was no interaction between genotype and benefit from
docetaxel
.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Help with Docetaxel
Docetaxel
not working for me! PSA goes up after every dose. NOT sure it's worth the side effects. Any suggestions ?
Docetaxel
not working for me! PSA goes up after every dose. NOT sure it's worth the side effects. Any suggestions ?
roblinic
in
Advanced Prostate Cancer
5 years ago
Aggressive Clinical Trial Patient at JH
Began clinical trial in September 2019 as follows: Lupron (scheduled to be ongoing for 2 years unless guidelines change) 4 cycles of
docetaxel
chemo in November 2 months Zytiga 1000mg/day w prednisone 5 mg November-December 37 IMRT radiation treatments to pelvis and prostate bed completed last
Began clinical trial in September 2019 as follows: Lupron (scheduled to be ongoing for 2 years unless guidelines change) 4 cycles of
docetaxel
chemo in November 2 months Zytiga 1000mg/day w prednisone 5 mg November-December 37 IMRT radiation treatments to pelvis and prostate bed completed last
London441
in
Prostate Cancer Network
4 years ago
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Statin and COX2 inhibitor for MCRPC?
We then embarked on
Docetaxel
10 cycles and 12months after starting chemo his PSA is rising again currently 7.5 at present. We are about to have another PSMA to look for any bone target that might be worth some radiotherapy, just incase it is one or two sites that have progressed.
We then embarked on
Docetaxel
10 cycles and 12months after starting chemo his PSA is rising again currently 7.5 at present. We are about to have another PSMA to look for any bone target that might be worth some radiotherapy, just incase it is one or two sites that have progressed.
Rubyrose1234
in
Advanced Prostate Cancer
4 years ago
Running out of options
He has had
Docetaxel
, all the hormone treatments, radiation and most of the injections. He has been on Zytiga and Abiraterone, plus steroids. Oncologist is looking into Immune therapy and has also offered the last chemotherapy available. Percentage is between 10-25 % effective. So not great odds.
He has had
Docetaxel
, all the hormone treatments, radiation and most of the injections. He has been on Zytiga and Abiraterone, plus steroids. Oncologist is looking into Immune therapy and has also offered the last chemotherapy available. Percentage is between 10-25 % effective. So not great odds.
Mac59
in
Advanced Prostate Cancer
4 years ago
PSA Up During Docetaxel, Scan indicates progression. Determined, Next step??
Started on
Docetaxel
with minimal side effects, However, after second treatment PSA rose from 4 to 11.3. MO discontinued
Docetaxel
after 5th treatment when scans indicated disease progression. And now Barry's in pain!! I thought he'd escape that, at least for longer.
Started on
Docetaxel
with minimal side effects, However, after second treatment PSA rose from 4 to 11.3. MO discontinued
Docetaxel
after 5th treatment when scans indicated disease progression. And now Barry's in pain!! I thought he'd escape that, at least for longer.
Barbara345
in
Advanced Prostate Cancer
4 years ago
Bilateral pleural effusions and basil pulmonary atelectasis
He developed lymphedema on both legs and one arm right after his 6th
Docetaxel
on December 5, 2019. Does the above new development have to do with lymphedema or is it something else?
He developed lymphedema on both legs and one arm right after his 6th
Docetaxel
on December 5, 2019. Does the above new development have to do with lymphedema or is it something else?
Hidden
in
Advanced Prostate Cancer
4 years ago
Help with next steps please
Failed xtandi, zytiga,
docetaxel
. I know hospice is around the corner and we are also waiting phone calls on a couple of immunotherapy trials. My question is there anything left to try at this point?
Failed xtandi, zytiga,
docetaxel
. I know hospice is around the corner and we are also waiting phone calls on a couple of immunotherapy trials. My question is there anything left to try at this point?
Dalipup
in
Advanced Prostate Cancer
4 years ago
PSA Up During Docetaxel, Scan indicates progression. Determined, Next step??
He Started
Docetaxel
with minimal side effects, However, from 2nd to 5th treatment PSA rose from 4 to 11.3. Scans indicated progression, so MO discontinued
Docetaxel
after 5th treatment. And now Barry's in pain!! I thought he'd escape that, at least for longer. Now -- considering what next?
He Started
Docetaxel
with minimal side effects, However, from 2nd to 5th treatment PSA rose from 4 to 11.3. Scans indicated progression, so MO discontinued
Docetaxel
after 5th treatment. And now Barry's in pain!! I thought he'd escape that, at least for longer. Now -- considering what next?
Barbara345
in
Advanced Prostate Cancer
4 years ago
Anyone taking Darolutamide develope asthenia, a known side effect? I've read similar SEs with Xtandi, so is this with all lutamide drugs?
He did the SOC treatment with
Docetaxel
chemo, then the cancer came back a couple months later in his lower spine, so he had 10 RT treatments to his L1-4, Jan 2018, During this time (while not being on any systemic treatment other than Lupron shots every 3 months) the cancer spread to his liver, so
He did the SOC treatment with
Docetaxel
chemo, then the cancer came back a couple months later in his lower spine, so he had 10 RT treatments to his L1-4, Jan 2018, During this time (while not being on any systemic treatment other than Lupron shots every 3 months) the cancer spread to his liver, so
JLS1
in
Advanced Prostate Cancer
4 years ago
Xtandi v Zytiga v Docetaxel
I have been told I am now Stage 4- PSA doubled in past 2 months from 6-14, T now is 51 after 3rd Lupron shot, with sabbatical to every 6 mos. Onc gave me these 3 options along with Patient Education from Kaiser. After reading about possible side effects, has anyone had experience and suggestions for
I have been told I am now Stage 4- PSA doubled in past 2 months from 6-14, T now is 51 after 3rd Lupron shot, with sabbatical to every 6 mos. Onc gave me these 3 options along with Patient Education from Kaiser. After reading about possible side effects, has anyone had experience and suggestions for
arete1105
in
Advanced Prostate Cancer
5 years ago
Docetaxel, Chemo in general
His doctors have all told him to start
Docetaxel
right away, at least to buy him time until the study begins. He is adamantly against chemo and believes he will get sick until he dies. Period, He is in excruciating pain now but as far as we can tell still only has Mets to bones.
His doctors have all told him to start
Docetaxel
right away, at least to buy him time until the study begins. He is adamantly against chemo and believes he will get sick until he dies. Period, He is in excruciating pain now but as far as we can tell still only has Mets to bones.
Hidden
in
Advanced Prostate Cancer
5 years ago
Dr says Enzalutimide... what about Cabazitaxel?
I've made it into my 50s, living with cancer for about 8 years now... 2012: Diagnosis Gleason 4+4=8 and tx with Cyberknife (PSA 21) 2014: Scans confirm metastatic disease confirmed in lungs and one bone lesion (PSA 10), tx with 6 rounds
Docetaxel
and begin Lupron/Casodex 2018: PSA first becomes detectable
I've made it into my 50s, living with cancer for about 8 years now... 2012: Diagnosis Gleason 4+4=8 and tx with Cyberknife (PSA 21) 2014: Scans confirm metastatic disease confirmed in lungs and one bone lesion (PSA 10), tx with 6 rounds
Docetaxel
and begin Lupron/Casodex 2018: PSA first becomes detectable
Tak-Druk
in
Advanced Prostate Cancer
4 years ago
ASCO GU 2020: Additional Mechanism of Action of PARP Inhibitor Talazoparib Attacks Prostate Cancer Cells, Spares Normal Cells
February 13, 2020—San Francisco, California—Talazoparib monotherapy has demonstrated encouraging antitumor activity in
docetaxel
-pretreated patients with metastatic, castration-resistant prostate cancer, especially those harboring BRCA1/2 mutations, and was generally well tolerated.
February 13, 2020—San Francisco, California—Talazoparib monotherapy has demonstrated encouraging antitumor activity in
docetaxel
-pretreated patients with metastatic, castration-resistant prostate cancer, especially those harboring BRCA1/2 mutations, and was generally well tolerated.
Balsam01
in
Advanced Prostate Cancer
4 years ago
PSA measures and Chemo
I have begun
Docetaxel
infusion completing the first cycle. Are PSA measures meaningful during chemo? My Doctor runs PSA, but places more emphasis on bone scans. I am continuing with Xtandi and Lupron during the chemo.
I have begun
Docetaxel
infusion completing the first cycle. Are PSA measures meaningful during chemo? My Doctor runs PSA, but places more emphasis on bone scans. I am continuing with Xtandi and Lupron during the chemo.
Shepard
in
Advanced Prostate Cancer
5 years ago
Chemo-related neuropathy developing despite ice mitts and socks. Anything that can be added now?
My husband is about to get infusion #6 of
Docetaxel
in three days. He's been religious about using the ice mitts and ice socks during the infusion. (He doesn't use an ice cap on his head.) Despite the ice regime, this week he started to feel some tingling in his heel and fingertips.
My husband is about to get infusion #6 of
Docetaxel
in three days. He's been religious about using the ice mitts and ice socks during the infusion. (He doesn't use an ice cap on his head.) Despite the ice regime, this week he started to feel some tingling in his heel and fingertips.
spouse21
in
Advanced Prostate Cancer
5 years ago
Upfront Docetaxel - STAMPEDE trial update.
There was good evidence of benefit of
docetaxel
over SOC on OS (HR = 0.81, 95% CI 0.69-0.95, P = 0.009) with no evidence of heterogeneity of
docetaxel
effect between metastatic burden sub-groups (interaction P = 0.827).
There was good evidence of benefit of
docetaxel
over SOC on OS (HR = 0.81, 95% CI 0.69-0.95, P = 0.009) with no evidence of heterogeneity of
docetaxel
effect between metastatic burden sub-groups (interaction P = 0.827).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
PSMA in circulating tumor cells is a new poor prognostic marker for castration-resistant PCa - Plos One - Published: January 27, 2020
Several drugs available for sequential therapy of CRPC, such as enzalutamide (ENZ), abiraterone (ABI),
docetaxel
(DOC), cabazitaxel (CBZ) and radium-223, have been shown to prolong the survival of CRPC patients [2].
Several drugs available for sequential therapy of CRPC, such as enzalutamide (ENZ), abiraterone (ABI),
docetaxel
(DOC), cabazitaxel (CBZ) and radium-223, have been shown to prolong the survival of CRPC patients [2].
cujoe
in
Fight Prostate Cancer
4 years ago
Maybe some one can tell me how to have Lu177 in Germany?
Doctor in my country and singapore said i must take
docetaxel
for 10 times. But im avoiding chemotheraphy because i feel i cant deal with the side effect. Im contacting with bookinghealth and they gave me an option to have Lu177 in Charite or Helios hospital. The cost estimated €29,000.
Doctor in my country and singapore said i must take
docetaxel
for 10 times. But im avoiding chemotheraphy because i feel i cant deal with the side effect. Im contacting with bookinghealth and they gave me an option to have Lu177 in Charite or Helios hospital. The cost estimated €29,000.
adipras
in
Advanced Prostate Cancer
5 years ago
New member
Docetaxel
or Zytiga I’m 66 years old and was just diagnosed with advanced prostate cancer. It has spread to bones, lungs and lymph node. My PSA was 29, grade 3 and Gleason score 7. I live in Canada and the standard of care is chemo or Zytiga. I’m on ADT.
Docetaxel
or Zytiga I’m 66 years old and was just diagnosed with advanced prostate cancer. It has spread to bones, lungs and lymph node. My PSA was 29, grade 3 and Gleason score 7. I live in Canada and the standard of care is chemo or Zytiga. I’m on ADT.
Zozo123
in
Advanced Prostate Cancer
5 years ago
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