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Docetaxel
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Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
Common CRPC Treatment Options Drug Class Drug Name (Established) Approval Year Indication T axane-based chemotherapeutic
Docetaxel
1996 mCRPC101 Cabazitaxel 2010 mCRPC with previous
docetaxel
treatment102 Immunotherapy Sipuleucel-T 2010 Asymptomatic
Common CRPC Treatment Options Drug Class Drug Name (Established) Approval Year Indication T axane-based chemotherapeutic
Docetaxel
1996 mCRPC101 Cabazitaxel 2010 mCRPC with previous
docetaxel
treatment102 Immunotherapy Sipuleucel-T 2010 Asymptomatic
pjoshea13
in
Advanced Prostate Cancer
4 years ago
PIK3CA mutation
I've had
docetaxel
(fail) Cabazitaxel (fail) carboplatin (fail) and the cancer no longer requires testosterone as a metabolite. I'm in deep shit and hoping there is still a get out of jail card I can use.
I've had
docetaxel
(fail) Cabazitaxel (fail) carboplatin (fail) and the cancer no longer requires testosterone as a metabolite. I'm in deep shit and hoping there is still a get out of jail card I can use.
Easey
in
Advanced Prostate Cancer
4 years ago
Exploring options: BAT, Docetaxel (again) ARV 110
Getting 10 rounds of
Docetaxel
is a good option at this point. However, we are also looking into the ARV-110 trials being conducted at Yale. Dr Beltran has been in contact with them and someone from Yale is calling my brother tomorrow.
Getting 10 rounds of
Docetaxel
is a good option at this point. However, we are also looking into the ARV-110 trials being conducted at Yale. Dr Beltran has been in contact with them and someone from Yale is calling my brother tomorrow.
Faith1111
in
Advanced Prostate Cancer
4 years ago
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Next Steps after Cabazitaxel and Xtandi
The cancer metastasized to 3 bones at that time and I underwent aggressive treatment at NIH with
Docetaxel
and PROSTVAC along with Lupron. When the PSA started rising again after 18 months, I switched to Standard of Care at home with Xtandi and Lupron.
The cancer metastasized to 3 bones at that time and I underwent aggressive treatment at NIH with
Docetaxel
and PROSTVAC along with Lupron. When the PSA started rising again after 18 months, I switched to Standard of Care at home with Xtandi and Lupron.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
Stopping Prednisone
My MO has me weening down my prednisone intake since ending my
docetaxel
regimen. I was on 10 mg per day. I did a week already at 5 mg per day. I am noticing mild pain in my bones already. I am stage 4 metastatic. I have extensive mets. I had no side effects from the prednisone.
My MO has me weening down my prednisone intake since ending my
docetaxel
regimen. I was on 10 mg per day. I did a week already at 5 mg per day. I am noticing mild pain in my bones already. I am stage 4 metastatic. I have extensive mets. I had no side effects from the prednisone.
Pianodude
in
Advanced Prostate Cancer
4 years ago
SOC is working for me - so far anyway.
I had a great response to the standard care of Zoladex and 6 sessions of
Docetaxel
. Scans in May 2019 and showed a significant reduction in tumour volume, my PSA reduced from 152 at diagnosis to a nadir of 0.07 in May 2019 and then a statistically insignificant decline to 0.06 in February 2020.
I had a great response to the standard care of Zoladex and 6 sessions of
Docetaxel
. Scans in May 2019 and showed a significant reduction in tumour volume, my PSA reduced from 152 at diagnosis to a nadir of 0.07 in May 2019 and then a statistically insignificant decline to 0.06 in February 2020.
Bjry
in
Advanced Prostate Cancer
4 years ago
Please share your personal experience and references, but check your biases at the door
Someone on this site "cited" very minimal benefit from
Docetaxel
and presented Lupron as more harm than good. I'm 3+ years into my 3rd remission after
Docetaxel
and Lupron. I hated Lupron, but if it helped stall my cancer while I had other treatments, then I'm happy.
Someone on this site "cited" very minimal benefit from
Docetaxel
and presented Lupron as more harm than good. I'm 3+ years into my 3rd remission after
Docetaxel
and Lupron. I hated Lupron, but if it helped stall my cancer while I had other treatments, then I'm happy.
ron_bucher
in
Advanced Prostate Cancer
4 years ago
Tumour marker spiked again, anyone had this and it's not being progression?
Good morning, Yesterday I had my H&P infusions, the second lot on their own without
docetaxel
which ended in August.
Good morning, Yesterday I had my H&P infusions, the second lot on their own without
docetaxel
which ended in August.
Hidden
in
SHARE Metastatic Breast Cancer
4 years ago
Any treatments left?
He has been on abiraterone, Xtandi twice, zytiga,
Docetaxel
, radium-223, BAT and now he is about to get his 8th treatment of Jevtana. He is 77 years old and is tolerating the Jevtana pretty well. His recent bloodwork shows his PSA is a little over 1000 and his phosphates are just over 300.
He has been on abiraterone, Xtandi twice, zytiga,
Docetaxel
, radium-223, BAT and now he is about to get his 8th treatment of Jevtana. He is 77 years old and is tolerating the Jevtana pretty well. His recent bloodwork shows his PSA is a little over 1000 and his phosphates are just over 300.
Amandaslp78
in
Advanced Prostate Cancer
4 years ago
Is Xofigo a good option for extensive skeletal mets?
I finished my
Docetaxel
treatments after five of six rounds. They decided against the last one because of increasing numbness in my feet. I am still on Firmagon. My bone scan done last week showed a slight improvement in a couple of bones, but overall, not much change.
I finished my
Docetaxel
treatments after five of six rounds. They decided against the last one because of increasing numbness in my feet. I am still on Firmagon. My bone scan done last week showed a slight improvement in a couple of bones, but overall, not much change.
Pianodude
in
Advanced Prostate Cancer
4 years ago
Starting chemo tomorrow. What can we expect?
My dad starts tomorrow on
Docetaxel
. What can we expect? Anyway to prepare for tomorrow? Eating before or after? What helps, if anything? Again thank you in advance!!! πππ
My dad starts tomorrow on
Docetaxel
. What can we expect? Anyway to prepare for tomorrow? Eating before or after? What helps, if anything? Again thank you in advance!!! πππ
Weezer513
in
Advanced Prostate Cancer
4 years ago
Switching gears due to insurance denial of treatment plan
My MO was set to give me cabazitaxel with carboplatin as
docetaxel
was not working. However, insurance denied this treatment as not being beneficial.
My MO was set to give me cabazitaxel with carboplatin as
docetaxel
was not working. However, insurance denied this treatment as not being beneficial.
Maleko808
in
Advanced Prostate Cancer
4 years ago
Follow-up scan and other stuff
I was supposed to have my 6th and last
Docetaxel
infusion today. It was canceled because of my neuropathy in my feet which recently was getting worse. I also had a bone scan and pelvic CT scan last Thursday. I got the reports today. Slight shrinkage in a couple bones.
I was supposed to have my 6th and last
Docetaxel
infusion today. It was canceled because of my neuropathy in my feet which recently was getting worse. I also had a bone scan and pelvic CT scan last Thursday. I got the reports today. Slight shrinkage in a couple bones.
Pianodude
in
Advanced Prostate Cancer
4 years ago
Docetaxel and Carboplatin side effects
On Thursday 9-10, my husband had his first treatment with
Docetaxel
and Carboplatin. I was expecting him to be feeling some side effects, but he is doing great! Is this unusual? Since no other drug has had any effect on his cancer, I'm afraid these drugs are having no effect on him.
On Thursday 9-10, my husband had his first treatment with
Docetaxel
and Carboplatin. I was expecting him to be feeling some side effects, but he is doing great! Is this unusual? Since no other drug has had any effect on his cancer, I'm afraid these drugs are having no effect on him.
Loves2golf
in
Advanced Prostate Cancer
4 years ago
Jevtana beats 2nd-line hormonals as 3rd therapy on pain relief and QOL
Recall that even on a first treatment, the degree of side effects from
docetaxel
was no worse than Zytiga. The side effects were different in kind, but not in severity.
Recall that even on a first treatment, the degree of side effects from
docetaxel
was no worse than Zytiga. The side effects were different in kind, but not in severity.
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
APC doing end run on Docetaxel
I started second series.of
docetaxel
after Talapro2 trial began failing (Xtandi with talazoparib or placebo). Chemo round 1 brought psa from 20 to 9. Round 2, 9 to 4. Round 4 to 8. We did scan just before chemo and again last week. Progression is seen with new bone Mets.
I started second series.of
docetaxel
after Talapro2 trial began failing (Xtandi with talazoparib or placebo). Chemo round 1 brought psa from 20 to 9. Round 2, 9 to 4. Round 4 to 8. We did scan just before chemo and again last week. Progression is seen with new bone Mets.
Maleko808
in
Advanced Prostate Cancer
4 years ago
Great news, I can stop taking Lupron
I went straight on ADT (daily 50mg Casodex and 3 mth Eligard) commenced Chemotherapy (
Docetaxel
) in late Jan 20 and stopped taking Tamsulosin. I had 9 chemo shots but that wasn't enough, so I had a TURBT and 20 VMAT Radiation session to finish the job.
I went straight on ADT (daily 50mg Casodex and 3 mth Eligard) commenced Chemotherapy (
Docetaxel
) in late Jan 20 and stopped taking Tamsulosin. I had 9 chemo shots but that wasn't enough, so I had a TURBT and 20 VMAT Radiation session to finish the job.
Doseydoe
in
Advanced Prostate Cancer
4 years ago
Whats after docetaxol and how much time
Hello I have not written in awhile...things are getting pretty bad. We were diagnosed in 2013 with stage 4. We have done Lupron pretty much continuously, removed prostate, radiation to area, Zytiga with Prednisone, Xofigo, and now Docetaxol. His PSA is over 2000. He is in pain everywhere....I am
Hello I have not written in awhile...things are getting pretty bad. We were diagnosed in 2013 with stage 4. We have done Lupron pretty much continuously, removed prostate, radiation to area, Zytiga with Prednisone, Xofigo, and now Docetaxol. His PSA is over 2000. He is in pain everywhere....I am
lovemyhusband4945
in
Advanced Prostate Cancer
4 years ago
Next in line
He still pushes for that first instead of
docetaxel
. I asked him if we could do xofigo directly after the Provenge and he seemed agreeable to that. Thinking of the recommendation that Tall Allen made suggesting that the combo may work better than either alone
He still pushes for that first instead of
docetaxel
. I asked him if we could do xofigo directly after the Provenge and he seemed agreeable to that. Thinking of the recommendation that Tall Allen made suggesting that the combo may work better than either alone
Peterd110
in
Advanced Prostate Cancer
4 years ago
Patterns of Cancer Progression of Metastatic Hormone-sensitiveProstate Cancer in the ECOG3805 CHAARTED Trial
"ECOG3805 is a randomized trial of testosterone suppression with or without
docetaxel
for metastatic hormone-sensitive prostate cancer (mHSPC).
"ECOG3805 is a randomized trial of testosterone suppression with or without
docetaxel
for metastatic hormone-sensitive prostate cancer (mHSPC).
tango65
in
Advanced Prostate Cancer
4 years ago
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