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PSA Response From Broccoli Sprout Extract (Sulforaphane) May Due To Just Being Moderate ADT
This reminds me of the debacle over PC-SPES that was a combination of supplements that got a lot of hype only to find it also contained the drug was
diethylstilbestrol
(also called diethylstilboestrol).
Diethylstilbestrol
is a hormone therapy. Interestingly my primary treatment Urologist, Dr.
This reminds me of the debacle over PC-SPES that was a combination of supplements that got a lot of hype only to find it also contained the drug was
diethylstilbestrol
(also called diethylstilboestrol).
Diethylstilbestrol
is a hormone therapy. Interestingly my primary treatment Urologist, Dr.
jazj
in
Advanced Prostate Cancer
7 months ago
Fosfestrol (Honvan)
There were men who discussed where to obtain Honvan (Forfestrol) a DES (
Diethylstilbestrol
) prodrug - usually Mexico. Some cut the pills up & managed to control progression with quite low doses. (These days, India may be a better bet than Mexico.) The study was on men with metastatic CRPC.
There were men who discussed where to obtain Honvan (Forfestrol) a DES (
Diethylstilbestrol
) prodrug - usually Mexico. Some cut the pills up & managed to control progression with quite low doses. (These days, India may be a better bet than Mexico.) The study was on men with metastatic CRPC.
pca2004
in
Fight Prostate Cancer
11 months ago
Androstenedione & Frailty
For many years, I used a product that probably contained DES (
diethylstilbestrol
) - perhaps 1 mg? My QoL was very good. When I eventually migrated to 3 mg DES - plus a shot of testosterone cypionate every 3 months - I began to feel frail.
For many years, I used a product that probably contained DES (
diethylstilbestrol
) - perhaps 1 mg? My QoL was very good. When I eventually migrated to 3 mg DES - plus a shot of testosterone cypionate every 3 months - I began to feel frail.
pca2004
in
Fight Prostate Cancer
9 months ago
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BCR May Not Be a Strong Surrogate End Point for Prostate Cancer Survival
{This was sufficient for me to delay Lupron as long as I could (I still haven't used it, but I do use DES [
Diethylstilbestrol
]) and to develop the hypothesis that periodic testosterone replacement might be useful during ADT, to reverse adaptations.}
{This was sufficient for me to delay Lupron as long as I could (I still haven't used it, but I do use DES [
Diethylstilbestrol
]) and to develop the hypothesis that periodic testosterone replacement might be useful during ADT, to reverse adaptations.}
pca2004
in
Fight Prostate Cancer
11 months ago
Transdermal E2 Gel
Prior to that time most men who experienced Biochemical Recurrence (BCR) of prostate cancer after primary treatments were given an inexpensive, synthetic, and very effective estrogen pill called
Diethylstilbestrol
(DES).
Prior to that time most men who experienced Biochemical Recurrence (BCR) of prostate cancer after primary treatments were given an inexpensive, synthetic, and very effective estrogen pill called
Diethylstilbestrol
(DES).
E2-Guy
in
Advanced Prostate Cancer
2 years ago
PSA suppression
In the end, I decided to skip Abi, Enza & Lupron and go back in time to DES (
diethylstilbestrol
). It's a synthetic estrogen that maintains bone health even while estradiol falls to zero. And it has anti-PCa properties.
In the end, I decided to skip Abi, Enza & Lupron and go back in time to DES (
diethylstilbestrol
). It's a synthetic estrogen that maintains bone health even while estradiol falls to zero. And it has anti-PCa properties.
pca2004
in
Fight Prostate Cancer
8 months ago
Bone Density - Dexa
I read somewhere that in the pre-Lupron days when DES (
Diethylstilbestrol
) was commonly used, bone loss was not a major issue.
I read somewhere that in the pre-Lupron days when DES (
Diethylstilbestrol
) was commonly used, bone loss was not a major issue.
pjoshea13
in
Fight Prostate Cancer
1 year ago
Estrogen therapy rediscovered
The latter was done with
diethylstilbestrol
(DES) offered as fosfestrol and many further names. In India
diethylstilbestrol
is offered as Honvan and still used today against prostate cancer. In men, the required estrogen is produced from testosterone.
The latter was done with
diethylstilbestrol
(DES) offered as fosfestrol and many further names. In India
diethylstilbestrol
is offered as Honvan and still used today against prostate cancer. In men, the required estrogen is produced from testosterone.
GP24
in
Advanced Prostate Cancer
4 years ago
35 month tE2 update
To the best of my knowledge DES (
diethylstilbestrol
), which was an 'oral' estrogen is no longer available due to the increased risk of cardio events. That's my story and I'm sticking to it! Feel free to contact me...Ron
To the best of my knowledge DES (
diethylstilbestrol
), which was an 'oral' estrogen is no longer available due to the increased risk of cardio events. That's my story and I'm sticking to it! Feel free to contact me...Ron
E2-Guy
in
Advanced Prostate Cancer
4 years ago
Free vs Total Testosterone? - Redux.
The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of
diethylstilbestrol
(23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate
The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of
diethylstilbestrol
(23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate
pjoshea13
in
Advanced Prostate Cancer
4 years ago
CRPC & Transdermal Estrogen
Note: "Patients who progressed were offered
diethylstilbestrol
." [DES] "[u]Fifty percent of patients subsequently responded to low-dose
diethylstilbestrol
.[/u]" DES, of course, is the synthetic estrogen that was standard for 30-40 years before Lupron.
Note: "Patients who progressed were offered
diethylstilbestrol
." [DES] "[u]Fifty percent of patients subsequently responded to low-dose
diethylstilbestrol
.[/u]" DES, of course, is the synthetic estrogen that was standard for 30-40 years before Lupron.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
How many of you are using tE2 as your only form of ADT?
I imagine most of you know something about the old, synthetic, oral estrogen DES (
diethylstilbestrol
) that was used as ADT until the mid 80's when it was discontinued and replaced with Lupron (leuprolide).
I imagine most of you know something about the old, synthetic, oral estrogen DES (
diethylstilbestrol
) that was used as ADT until the mid 80's when it was discontinued and replaced with Lupron (leuprolide).
E2-Guy
in
Advanced Prostate Cancer
4 years ago
Endocrine disrupting chemicals (EDCs) & Diabetes.
Chemicals that are known endocrine disruptors include
diethylstilbestrol
(the synthetic estrogen DES), dioxin and dioxin-like compounds, polychlorinated biphenyls (PCBs), DDT, and some other pesticides.
Chemicals that are known endocrine disruptors include
diethylstilbestrol
(the synthetic estrogen DES), dioxin and dioxin-like compounds, polychlorinated biphenyls (PCBs), DDT, and some other pesticides.
gangadharan_nair
in
Diabetes India
5 years ago
Diethylstilbestrol when faced with "economic constraint".
KEYWORDS: castrate resistant prostate cancer;
diethylstilbestrol
PMID: 31249748 PMCID: PMC6579324 DOI: 10.7759/cureus.4470
KEYWORDS: castrate resistant prostate cancer;
diethylstilbestrol
PMID: 31249748 PMCID: PMC6579324 DOI: 10.7759/cureus.4470
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Diethylstilbestrol [DES]
-Patrick [1] https://en.wikipedia.org/wiki/
Diethylstilbestrol
-Patrick [1] https://en.wikipedia.org/wiki/
Diethylstilbestrol
pjoshea13
in
Advanced Prostate Cancer
5 years ago
PCa Abbreviation List UPDATED 1/26/2023
acetate •CP = capsular penetration •CRPC = castration-resistant prostate cancer •CREAT = creatinine •CRYO = cryotherapy, cryoablation, cryosurgery •CS = clinical stage •CT SCAN = computerized tomography (also known as CAT scan or CT scan) •D = diploid •DART = dynamic adaptive radiation therapy •DES =
diethylstilbestrol
acetate •CP = capsular penetration •CRPC = castration-resistant prostate cancer •CREAT = creatinine •CRYO = cryotherapy, cryoablation, cryosurgery •CS = clinical stage •CT SCAN = computerized tomography (also known as CAT scan or CT scan) •D = diploid •DART = dynamic adaptive radiation therapy •DES =
diethylstilbestrol
Moespy
in
Advanced Prostate Cancer
6 years ago
HIF-1α inhibition by DES.
We are 30+ years into the Lupron era, but
diethylstilbestrol
[DES] was used for about 45 years before that & shouldn't be entirely ignored. DES is a synthetic estrogen.
We are 30+ years into the Lupron era, but
diethylstilbestrol
[DES] was used for about 45 years before that & shouldn't be entirely ignored. DES is a synthetic estrogen.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of
diethylstilbestrol
(23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate
The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of
diethylstilbestrol
(23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Occult cancer in patients with deep-vein thrombosis [DVT].
It is fairly well-known that the old ADT treatment,
diethylstilbestrol
[DES], a synthetic estradiol, increased the risk for thromboembolic events, but it appears that castration therapy can also increase risk. Nattokinase can accelerate the breakdown of the fibrin in growing clots.
It is fairly well-known that the old ADT treatment,
diethylstilbestrol
[DES], a synthetic estradiol, increased the risk for thromboembolic events, but it appears that castration therapy can also increase risk. Nattokinase can accelerate the breakdown of the fibrin in growing clots.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Prostate Cancer & Hormones - Insulin-like growth factor [IGF] axis.
Remarkably, 3 mg per day of
diethylstilbestrol
(DES) taken orally maintained disease stability for 24 years, at which time his PSA began to rise despite a castrate level of testosterone (28 ng/dl). His bone scan showed metastatic disease to the thoracic spine, sternum, and multiple ribs.
Remarkably, 3 mg per day of
diethylstilbestrol
(DES) taken orally maintained disease stability for 24 years, at which time his PSA began to rise despite a castrate level of testosterone (28 ng/dl). His bone scan showed metastatic disease to the thoracic spine, sternum, and multiple ribs.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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