Experiences with

Diethylstilbestrol

This reminds me of the debacle over PC-SPES that was a combination of supplements that got a lot of hype only to find it also contained the drug was diethylstilbestrol (also called diethylstilboestrol). Diethylstilbestrol is a hormone therapy. Interestingly my primary treatment Urologist, Dr.

There were men who discussed where to obtain Honvan (Forfestrol) a DES (Diethylstilbestrol) prodrug - usually Mexico. Some cut the pills up & managed to control progression with quite low doses. (These days, India may be a better bet than Mexico.) The study was on men with metastatic CRPC.

For many years, I used a product that probably contained DES (diethylstilbestrol) - perhaps 1 mg? My QoL was very good. When I eventually migrated to 3 mg DES - plus a shot of testosterone cypionate every 3 months - I began to feel frail.

{This was sufficient for me to delay Lupron as long as I could (I still haven't used it, but I do use DES [Diethylstilbestrol]) and to develop the hypothesis that periodic testosterone replacement might be useful during ADT, to reverse adaptations.}

In the end, I decided to skip Abi, Enza & Lupron and go back in time to DES (diethylstilbestrol). It's a synthetic estrogen that maintains bone health even while estradiol falls to zero. And it has anti-PCa properties.

Prior to that time most men who experienced Biochemical Recurrence (BCR) of prostate cancer after primary treatments were given an inexpensive, synthetic, and very effective estrogen pill called Diethylstilbestrol (DES).

I read somewhere that in the pre-Lupron days when DES (Diethylstilbestrol) was commonly used, bone loss was not a major issue.

The latter was done with diethylstilbestrol (DES) offered as fosfestrol and many further names. In India diethylstilbestrol is offered as Honvan and still used today against prostate cancer. In men, the required estrogen is produced from testosterone.

To the best of my knowledge DES (diethylstilbestrol), which was an 'oral' estrogen is no longer available due to the increased risk of cardio events. That's my story and I'm sticking to it! Feel free to contact me...Ron

The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of diethylstilbestrol (23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate

Note: "Patients who progressed were offered diethylstilbestrol." [DES] "[u]Fifty percent of patients subsequently responded to low-dose diethylstilbestrol.[/u]" DES, of course, is the synthetic estrogen that was standard for 30-40 years before Lupron.

I imagine most of you know something about the old, synthetic, oral estrogen DES (diethylstilbestrol) that was used as ADT until the mid 80's when it was discontinued and replaced with Lupron (leuprolide).

Chemicals that are known endocrine disruptors include diethylstilbestrol (the synthetic estrogen DES), dioxin and dioxin-like compounds, polychlorinated biphenyls (PCBs), DDT, and some other pesticides.

KEYWORDS: castrate resistant prostate cancer; diethylstilbestrol PMID: 31249748 PMCID: PMC6579324 DOI: 10.7759/cureus.4470

-Patrick [1] https://en.wikipedia.org/wiki/Diethylstilbestrol

acetate •CP = capsular penetration •CRPC = castration-resistant prostate cancer •CREAT = creatinine •CRYO = cryotherapy, cryoablation, cryosurgery •CS = clinical stage •CT SCAN = computerized tomography (also known as CAT scan or CT scan) •D = diploid •DART = dynamic adaptive radiation therapy •DES = diethylstilbestrol

We are 30+ years into the Lupron era, but diethylstilbestrol [DES] was used for about 45 years before that & shouldn't be entirely ignored. DES is a synthetic estrogen.

The study by Byar was also able to show a contributing effect of insufficient androgen suppression on overall mortality, however, this effect was observed with the administration of diethylstilbestrol (23), and unlike our current study, not with LHRH analogues in conjunction with abiraterone acetate

It is fairly well-known that the old ADT treatment, diethylstilbestrol [DES], a synthetic estradiol, increased the risk for thromboembolic events, but it appears that castration therapy can also increase risk. Nattokinase can accelerate the breakdown of the fibrin in growing clots.

Remarkably, 3 mg per day of diethylstilbestrol (DES) taken orally maintained disease stability for 24 years, at which time his PSA began to rise despite a castrate level of testosterone (28 ng/dl). His bone scan showed metastatic disease to the thoracic spine, sternum, and multiple ribs.