Aspirin - one more time.

[pjoshea13]

New study below [1].

"Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts"

This comes from the National Institutes of Health - I'm assuming that aspirin use has not yet become politicized. lol

"We pooled 423,495 individuals from two prospective, U.S.-based studies: the NIH-AARP Diet and Health Study (1995-2011) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (1993-2009)."

"Weak or null associations were observed for breast, endometrial, and aggressive prostate cancer, with no strong effect modification observed."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/331...

Cancer Causes Control

. 2020 Oct 26. doi: 10.1007/s10552-020-01357-2. Online ahead of print.

Associations between daily aspirin use and cancer risk across strata of major cancer risk factors in two large U.S. cohorts

Lauren M Hurwitz 1 , Kara A Michels 2 , Michael B Cook 2 , Ruth M Pfeiffer 2 , Britton Trabert 2

Affiliations collapse

Affiliations

1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, 20850, USA. [e-mail].

2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, 20850, USA.

PMID: 33104910 DOI: 10.1007/s10552-020-01357-2

Abstract

Purpose: Daily aspirin use has been shown to reduce risk of colorectal, and possibly other, cancers, but it is unknown if these benefits are consistent across subgroups of people with differing cancer risk factors. We investigated whether age, body mass index (BMI), smoking status, physical inactivity, and family history of cancer modify the effect of daily aspirin use on colorectal, ovarian, breast, endometrial and aggressive prostate cancer risk.

Methods: We pooled 423,495 individuals from two prospective, U.S.-based studies: the NIH-AARP Diet and Health Study (1995-2011) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (1993-2009). Using Cox proportional hazards regression, we examined associations between daily aspirin use (≥ 5 days/week) and risk of colorectal, ovarian, breast, endometrial, and aggressive prostate cancer, overall and across strata of risk factors.

Results: Daily aspirin use was associated with a 15% reduction in colorectal cancer risk (hazard ratio [HR]: 0.85, 95% confidence interval [CI] 0.80-0.89). Risk reductions were generally consistent across strata of risk factors but attenuated with increasing BMI (p-interaction = 0.16). For ovarian cancer, there was no significant association overall (HR: 0.93, 95% CI 0.80-1.08) but reduced risk among obese women (HR: 0.73, 95% CI 0.52-0.98, p-interaction = 0.12). Weak or null associations were observed for breast, endometrial, and aggressive prostate cancer, with no strong effect modification observed.

Conclusions: Daily aspirin use appears to reduce colorectal cancer risk regardless of other risk factors, though the potential modifying effect of BMI warrants further investigation and may need to be considered in risk-benefit calculations for aspirin use.

Keywords: Anti-inflammatory agents; Aspirin; Cancer risk; Chemoprevention; Effect modification; Non-steroidal.

Grant support

ZIA CP010128/ImNIH/Intramural NIH HHS/United States

[LearnAll]

81 mg Aspirin generally does good. This small dose can keep platelets from clumping together forming thrombi..thus reducing risk of thromboembolism.

Prostate cancer is a high clotting state and keeping blood less coagulable helps reduce un needed clots. For heart, 81 mg Aspirin does good too. Let nobody defame humble, inexpensive darling called Mini-Aspirin.

[cesanon in reply to LearnAll]

I think it's not so simple. While I use aspirin, I don't disregard the issue of potentially increase in stroke risk.

[LearnAll in reply to cesanon]

Cesanon...there are mainly 2 types of strokes....first type is called "thrombotic stroke" which means a clot forms and circulates in blood and goes and lodges in a brain artery causing paralysis. This type is most common and occurs in over 80% of all strokes.

Second type is "hemorrhagic stroke" much less common type. In this bleeding occurs in brain and that results in stroke. 81 mg Aspirin a day helps prevent the first type which is most of the cases of stroke. There is a very very little risk of slight increase in second type due to mini aspirin. But you will know it beforehand by looking at your platelet count ..if it goes below 50,0000 ,yes. .you can always stop Mini-Aspirin.

[cesanon in reply to LearnAll]

Interesting.

Do you know how much that 80% changes with age?

[LearnAll in reply to cesanon]

Ces...Strokes mostly happen in older humans. Actually, when lay people talk about stroke, they are basically talking about "thrombotic "type and with age this type becomes even more common.

[treedown]

Politicized, that's funny I assume everything is now.

[cesanon in reply to treedown]

huh?

[treedown in reply to cesanon]

Original Post "This comes from the National Institutes of Health - I'm assuming that aspirin use has not yet become politicized. lol"

[Hidden in reply to treedown]

Your name is political. But is it liberal because it has tree in it? Or conservative because it's tree DOWN?

I made sure to use the initials of my name. I hope that letters have not become political yet.

[MateoBeach in reply to Hidden]

And I thought perhaps it was a play on being a "Rishi", a far-sighted one or sage.

[Hidden in reply to MateoBeach]

I like that. Sage #1.

[LearnAll in reply to MateoBeach]

I wonder if the name "Reishi Mushroom" has something to do with "Rishi" BTW, Reishi mushroom is anti cancer....just like Turkey tail, Shitaki and Maitaki Mushrooms.

[pjoshea13 in reply to cesanon]

The NIH & all government scientific institutions are currently expected to stay "on message". Perhaps safer to be working on an aspirin study than COVID-19?

-Patrick

[Stevana]

While the NIH study isn’t supportive of low-dose aspirin use in the prevention to prostate cancer, the article below indicates low-dose aspirin along with omega-3 fatty acids can play a role in keeping tumor growth at bay after chemotherapy. It’s an interesting study and worth the read. Stay strong brothers. 💪 💪🌈

isbscience.org/news/2017/11...

[RonnyBaby]

I've read contradictions about Aspirin - I'm not going to add that to my 'supplement' list. I see no need for it. The point about 'blood thinning' is worthy of note - but there are others ways to achieve that and in 'general' terms, I can't see how it would be 'recommended'.

At least not for 'everybody'.

This is not to criticize ->

I'll await the next iteration, where the jury MIGHT rule in another direction .....

[j-o-h-n]

My ex-wife used to say that "I could give an aspirin a headache". I wonder what she meant by that?

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 10/29/2020 7:40 PM DST

[LearnAll]

thelancet.com/journals/lanc...

My dear Mini Aspirin slows metastases !

[pjoshea13 in reply to LearnAll]

"Slows" or prevents?

"That aspirin prevents distant metastasis could account for the early reduction in cancer deaths in trials of daily aspirin versus control."

I work on the assumption that metastasis depends on micro-clots. I wish I started out with an understanding of altered coagulation 16 years ago. I would have avoided a double DVT & various boney mets. But better late than never. Even when there are mets, one should not encourage the formation of others.

-Patrick

[LearnAll in reply to pjoshea13]

pubmed.ncbi.nlm.nih.gov/294...

ncbi.nlm.nih.gov/pmc/articl...

Yes....even when there are mets..one should try to contain them. Many herbs, spices ,nuts and other supplements have capacity to block Epithelial-Mesochymal transition.(EMT) And EMT is early step in progression of metastases. As I write this ,I am chewing betel leaves with Saffron and rose petals with it. My platelet count is 125,000 and MPV is 13.5 PLR 58.

I just ordered 5 grams of Saffron again from Amazon. I eat at least 5 grams a month.