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Can Levodopa Contribute to Gut Dysbiosis via Increased Gut Inflammation and More Dysbiosis? The Study Below Suggests It Can
In this 2021 study they showed through fecal DNA of 107 PwP that levodopa and especially Levodopa/
Carbidopa
Intestinal Gel (LCIG) are associated with an inflammatory microbiome.
In this 2021 study they showed through fecal DNA of 107 PwP that levodopa and especially Levodopa/
Carbidopa
Intestinal Gel (LCIG) are associated with an inflammatory microbiome.
chartist
in
Cure Parkinson's
3 years ago
Trying to get off Sinemet
Still stuck on Sinemet (100mg levidopa/25mg
carbidopa
) which augmented causing severe muscle rigidity along with the worsening RLS convulsions. It was originally prescribed over 2 years ago to reduce potential damages to 4th spinal surgery. No one realized it would be so difficult to stop.
Still stuck on Sinemet (100mg levidopa/25mg
carbidopa
) which augmented causing severe muscle rigidity along with the worsening RLS convulsions. It was originally prescribed over 2 years ago to reduce potential damages to 4th spinal surgery. No one realized it would be so difficult to stop.
betternowman
in
Restless Legs Syndrome
2 years ago
TEN (10) years and what have you learned?
What have you learned in respect to
carbidopa
levodopa?
What have you learned in respect to
carbidopa
levodopa?
Hidden
in
Cure Parkinson's
2 years ago
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RLS and Parkinson's
Hi everyone, I'm new here but have been reading a lot of posts and find it very helpful. Great to find this community that support each other. I wanted to tell about my mother’s condition to see if anyone has any helpful tips or insights. My mum has been diagnosed with Parkinson recently and has started
Hi everyone, I'm new here but have been reading a lot of posts and find it very helpful. Great to find this community that support each other. I wanted to tell about my mother’s condition to see if anyone has any helpful tips or insights. My mum has been diagnosed with Parkinson recently and has started
Fernando80
in
Restless Legs Syndrome
2 years ago
Underprescribing Sinemet for PD?
In 'The New PD Treatment Book' (2015) by Eric Ahlskog he says on page 164, start with one
carbidopa
/levodopa 25/100 3x daily, week 2 up the dose to 1.5 tablets 3x daily, week 3 increase to 2 tablets 3x daily, week 4 increase to 2.5; week 5 try 3 tablets 3x daily.
In 'The New PD Treatment Book' (2015) by Eric Ahlskog he says on page 164, start with one
carbidopa
/levodopa 25/100 3x daily, week 2 up the dose to 1.5 tablets 3x daily, week 3 increase to 2 tablets 3x daily, week 4 increase to 2.5; week 5 try 3 tablets 3x daily.
ramotswe
in
Cure Parkinson's
2 years ago
Equivalence between C/L meds and Mucuna Pruriens.
Does anyone have any knowledge or information on the enhancing effect of
carbidopa
in Sinemet-type medications compared to levodopa found in Mucuna? I believe I've read somewhere 4 or 5 times, is that approximately right?
Does anyone have any knowledge or information on the enhancing effect of
carbidopa
in Sinemet-type medications compared to levodopa found in Mucuna? I believe I've read somewhere 4 or 5 times, is that approximately right?
puretone
in
Cure Parkinson's
3 years ago
The end of Parkinson's as we know it today. From the Levodopa era to the "transformative" information era.
We cannot continue without introducing Mucuna (with or without
carbidopa
); homocysteine reduction with vitamins B2, B6, B9 and B12; the use of sublingual vitamin B12; substances that raise glutathione as well as providing innumerable benefits (alpha lipoic acid, vitamin C, selenium, turmeric, etc.);
We cannot continue without introducing Mucuna (with or without
carbidopa
); homocysteine reduction with vitamins B2, B6, B9 and B12; the use of sublingual vitamin B12; substances that raise glutathione as well as providing innumerable benefits (alpha lipoic acid, vitamin C, selenium, turmeric, etc.);
parkinsonshereandnow
in
Cure Parkinson's
2 years ago
Advise on drug s
Which drug would compliment
carbidopa
-levodopa to make it last long with the least side effects
Which drug would compliment
carbidopa
-levodopa to make it last long with the least side effects
akgirlsrock
in
Cure Parkinson's
3 years ago
Carbidopa/Levodopa Success Stories
Perhaps you saw Jim's recent excellent post "The Value Of
Carbidopa
Levodopa Demonstrated in Two Signatures" at https://healthunlocked.com/cure-parkinsons/posts/146518581/the-value-of-
carbidopa
-levodopa-demonstrated-in-two-signatures How has
carbidopa
/levodopa helped you?
Perhaps you saw Jim's recent excellent post "The Value Of
Carbidopa
Levodopa Demonstrated in Two Signatures" at https://healthunlocked.com/cure-parkinsons/posts/146518581/the-value-of-
carbidopa
-levodopa-demonstrated-in-two-signatures How has
carbidopa
/levodopa helped you?
Hidden
in
Cure Parkinson's
3 years ago
BioVie announces treatment of 1st patient in Phase 2 clinical trial of NE3107,ERK inhibitor that selectively inhibits neuroinflammation
Participants will be treated with
carbidopa
/levodopa and NE3107 or placebo. Forty patients with a defined PD medication “off state” will be randomized 1:1 placebo to: active NE3107 20 mg twice daily for 28 days.
Participants will be treated with
carbidopa
/levodopa and NE3107 or placebo. Forty patients with a defined PD medication “off state” will be randomized 1:1 placebo to: active NE3107 20 mg twice daily for 28 days.
Hidden
in
Cure Parkinson's
2 years ago
Supplementary management with Pycnogenol® in Parkinson's disease to prevent cognitive impairment 2020
The management for these patients was a monotherapy using
carbidopa
/levodopa (standard management; SM). Supplementary Pycnogenol® was used at 150 mg/day for 4 weeks. The neurological management was not affected.
The management for these patients was a monotherapy using
carbidopa
/levodopa (standard management; SM). Supplementary Pycnogenol® was used at 150 mg/day for 4 weeks. The neurological management was not affected.
Bolt_Upright
in
Cure Parkinson's
2 years ago
A Curmudgeonly Approach to Supplements and Research "Progress." 😊
They always circled back to that dreaded
carbidopa
levodopa stuff even though it had horrible side effects and they weren't particularly encouraging or enlightening.
They always circled back to that dreaded
carbidopa
levodopa stuff even though it had horrible side effects and they weren't particularly encouraging or enlightening.
jimcaster
in
Cure Parkinson's
3 years ago
B6 recommended with carbidopa levodopa.
I am 2.5 years dx with Pd and just started
carbidopa
levodopa. It helped quite a bit and took b6 (for depression) this morning and was amazed at how good I felt. Like I was 100 percent normal. I took too much as I have read.
I am 2.5 years dx with Pd and just started
carbidopa
levodopa. It helped quite a bit and took b6 (for depression) this morning and was amazed at how good I felt. Like I was 100 percent normal. I took too much as I have read.
38yroldmale
in
Cure Parkinson's
3 years ago
Clinical Trial Highlights – an update on previously reviewed trials (Phase 3 in focus)
Intec Pharma’s gastric retentive Accordion Pill™
Carbidopa
/Levodopa (AP-CD/LD) was being evaluated in a phase 3 study for its safety and efficacy in advanced PD.
Intec Pharma’s gastric retentive Accordion Pill™
Carbidopa
/Levodopa (AP-CD/LD) was being evaluated in a phase 3 study for its safety and efficacy in advanced PD.
Hidden
in
Cure Parkinson's
2 years ago
Dose Adjustment
My Dose
Carbidopa
levodopa IR 25/100 (2) Thiamine hcl 4 grams daily. Tentatively
Carbidopa
levodopa IR 25/100 (1) Thiamine hcl 6 grams daily.
My Dose
Carbidopa
levodopa IR 25/100 (2) Thiamine hcl 4 grams daily. Tentatively
Carbidopa
levodopa IR 25/100 (1) Thiamine hcl 6 grams daily.
Hidden
in
Cure Parkinson's
3 years ago
Parkinson's could be otherwise.
The patient had been diagnosed as usual, responded well to Sinemet (levodopa/
carbidopa
) and a SPECT DaT test confirmed the diagnosis. Neuroscientist Karishma Smart and colleagues published in 2016.
The patient had been diagnosed as usual, responded well to Sinemet (levodopa/
carbidopa
) and a SPECT DaT test confirmed the diagnosis. Neuroscientist Karishma Smart and colleagues published in 2016.
parkinsonshereandnow
in
Cure Parkinson's
2 years ago
Can anyone tell me why sometimes 100mg/10 mg levodopa/carbidopa is used instead of standard 100/25 version
Sinemet 100/10
Sinemet 100/10
Connie18
in
Cure Parkinson's
2 years ago
The Value Of Carbidopa Levodopa Demonstrated in Two Signatures
One of the first decisions a PwP must make is when (or whether) to begin taking medication. There is no correct answer and we all know how PD varies from person to person. I held off for 2 1/2 years after my diagnosis, but a relatively minor event today caused me to pause and think about how well sinemet
One of the first decisions a PwP must make is when (or whether) to begin taking medication. There is no correct answer and we all know how PD varies from person to person. I held off for 2 1/2 years after my diagnosis, but a relatively minor event today caused me to pause and think about how well sinemet
jimcaster
in
Cure Parkinson's
3 years ago
Sinemet / carbidopa levodopa
“In 1988, the U.S. Food and Drug Administration (FDA) is recommended that the daily dose of Sinemet should not exceed 800 mg per day, and as of 2013, this recommendation has not been revised. In 2018 the labeling of Sinemet recommends not exceeding a levodopa total daily dose of 2,000 mg per day. As
“In 1988, the U.S. Food and Drug Administration (FDA) is recommended that the daily dose of Sinemet should not exceed 800 mg per day, and as of 2013, this recommendation has not been revised. In 2018 the labeling of Sinemet recommends not exceeding a levodopa total daily dose of 2,000 mg per day. As
Hidden
in
Cure Parkinson's
3 years ago
Levodopa/Carbidopa and vitamin C
I am sorry if this was previously discussed but I couldn't find it anywhere. I was told to take my L/C with Emerg-C but I just can't get it down. Can I take it with an Ascorbic Acid supplement instead?
I am sorry if this was previously discussed but I couldn't find it anywhere. I was told to take my L/C with Emerg-C but I just can't get it down. Can I take it with an Ascorbic Acid supplement instead?
Missy0202
in
Cure Parkinson's
3 years ago
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