Experiences with

Busulfan

The consultant suggested they might try Busulfan as an alternative - this concerns me, as I have read about the adverse affects. We have an in person appointment at the hospital next week, and I am going with him.

He has been advised that he should start on either Busulfan or Pegylated Interferon. Hydroxycarbamide was tried for a few months prior to his commencement of Ruxolitinib which at that time had little effect to his pruritus.

Cytoreductive therapy is reserved for high-risk disease with first-line drugs of choice being hydroxyurea and pegylated interferon-α and second-line busulfan and ruxolitinib. In addition, systemic anticoagulation is advised in patients with venous thrombosis history.

since then neither my local hospital hematology or guy's hematology have been able to control my counts , going from high with platelets 4,000 ,WBC 33 ,neutrophils 29,then to lows of neutropenia, my medication was hydroxycarbamide and anagrelide , also had peg inf 180 micrograms, then they put me on busulfan

All I found was that Teferri at the Mayo clinic suggests busulfan. Can any of you share your experience/knowledge about this? Thanks

Everytime l complain about hydroxy side effects to the medics lt feels like lm threatened with Busulfan as the only other treatment option available other than Hydroxycarbamide which has many bad side effects for me.

Anagrelide and Busulfan don’t look attractive! PV dx2017, over 70 yrs so high risk. Any insights would be valuable. Thanks!

These very small, and older pre 2017, (2014-2015) studies were busulfan as 2nd line treatment where the regular drugs didn't work. The 1st study includes Dr Silver as an author. The 1st chart is quite impressive.

I am considering Hydroxyurea or Busulfan oral. I know this has been discussed previously but am interested in side effects if any you have encountered with these chemo drugs good and bad.

I am thinking about going on low dose Busulfan 2mg per day or 500mg Hydroxyurea.I would appreciate any input on side effects . Does it help fatigue or add to it. Thanks.

I was changed to Busulfan which gradually brought the count down.

My consultant is advising me to go onto either Busulfan or Ruxolitinib but concerned that either of these would reduce my immunity.

There is no problem with Busulfan and Lansoprazole. Has anybody been in a similar situation and what was their experience?

high blood pressure or diabetes, are considered more vulnerable and should follow the government’s guidelines for vulnerable individuals (see link above). 3.Patients under 70 years of age who are on medications to control their blood count or their MPN like Hydroxycarbamide, Interferon, Anagrelide, Busulfan

Patients under 70 who are on medications to control their blood count or their MPN, for example Hydroxycarbamide, Interferon, Anagrelide or Busulfan are in a group where the situation is unclear.

We are concerned that Busulfan may be getting no longer suitable. We have attended several MPN forums and Busulfan is rarely mentioned and it appears that Pegasus Interferon is more popular.

When I saw my haematologist a couple of weeks ago she asked if I would like to switch to busulfan to see if I have fewer side effects. Is anyone else on this medication? She said it wasn't offered to younger people because it can affect the lungs.

The patient then receives two days of low-dose busulfan, a chemotherapy drug that makes space in the marrow for the stem cells to grow, and the cells are then infused back into the patient. And the kids are all cured.

The pre-transplant checks went well and commenced conditioning with fludarabine, busulfan and rATG, while sharing a room with another patient who was soon to be discharged. His discharge did not last long and he returned. Turned out that he contracted influenza in his brief time away.

Have now been offered the option of either Radioactive Phosphorus P32, Busulfan or Interferon Alpha. Has anyone any information on these treatments.Incidentally leg ulcers have not quite healed and I am having cramp/burning feelings in lower leg and feet.