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Phase 1/2 of TLX592 Targeted Alpha Therapy in Prostate Cancer starting soon - Ac 225
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
3 months ago
Chronic sinus issues
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
I’m currently on an Xtandi, Zometa and Lupron treatment plan. Could there be a correlation between one of these drugs and chronic sinus stuffiness? I also take a cholesterol drug and 3 different blood pressure meds. Thanks in advance if anyone has information. My Best Jim
NDJIM
in
Advanced Prostate Cancer
3 months ago
Ped5i/Tadalafil etc as a benefit to SE of ADT?
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
pj1121
in
Advanced Prostate Cancer
3 months ago
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Will Existing Drugs Stop Cancer's Bone Spread? I don't know but it's driving me crazy!
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Just because I cannot know which are the two repurposed drugs that seem to have such great results with metastasis. The chief researcher is Neta Erez who has great reputation in research about bone metastasis. I am inclined to think about Ivermectin as one of the possible components of the cocktail,
Maxone73
in
Fight Prostate Cancer
3 months ago
Is Orgovyx as effective as Lupron/Degarelix ?
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
My Dad , 83 , with bone mets has started bicalutamide since a week and is soon to take the Lupron shot. But he has a fear of injections as many years back he has developed an abscess due to an injection wrongly given. Is orgovyx as effective as the injections in reducing testesterone ? One doctor
Tinkudi
in
Advanced Prostate Cancer
3 months ago
Lupron - are there heart risks?
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
My father , 83 , recently got diagnosed with Prostate cancer with mets to some bones , as per PSMA test. We have not done a biopsy as one doctor said there is no need to do it as treatment options won’t change but another doctor says it’s good to do it in case later down the line we need to add treatments
Tinkudi
in
Advanced Prostate Cancer
3 months ago
Bayer Starts Phase I Study With Novel Targeted Radionuclide Therapy 225Ac-PSMA-Trillium in Advanced Metastatic Prostate Cancer
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
225Ac-PSMA-Trillium (BAY 3563254) is an investigational next-generation PSMA-targeted alpha therapy with potential to treat patients with advanced metastatic prostate cancer Prostate cancer is the second most commonly diagnosed cancer in men1, with less than three years median survival among metastatic
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Drugs and high Calcium
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
My Oncologist wants me to take Prolia, but the Insurance will not pay for it and wants me to take Zometa. However, I did research on Zometa and its reputation is questionable. What are the alternatives? Xgeva seems better. Any thoughts about this.
Poollover
in
Advanced Prostate Cancer
3 months ago
Non invasive detection of neuroendocrine PCa
An innovation to detect neuroendocrine PCa...and one of the researchers is a friend so I wanted to promote this paper :-P https://www.urotoday.com/video-lectures/prostate-cancer/video/mediaitem/3995-non-invasive-detection-of-neuroendocrine-prostate-cancer-through-targeted-cell-free-dna-methylation-himisha-beltran-francesca-demichelis.html
An innovation to detect neuroendocrine PCa...and one of the researchers is a friend so I wanted to promote this paper :-P https://www.urotoday.com/video-lectures/prostate-cancer/video/mediaitem/3995-non-invasive-detection-of-neuroendocrine-prostate-cancer-through-targeted-cell-free-dna-methylation-himisha-beltran-francesca-demichelis.html
Maxone73
in
Advanced Prostate Cancer
3 months ago
Positive effect of diet on the whole PCa / APCa spectrum
https://www.urologytimes.com/view/plant-based-diet-demonstrates-benefits-along-spectrum-of-prostate-cancer +lots of exercise
https://www.urologytimes.com/view/plant-based-diet-demonstrates-benefits-along-spectrum-of-prostate-cancer +lots of exercise
Derf4223
in
Advanced Prostate Cancer
3 months ago
In vivo/vitro: Dickkopf-1 (DKK1) drives growth and metastases in castration-resistant prostate cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
...does "kopf" mean head? because I could switch to call my cancer dickkopf in that case! Anyway, thanks to CRISPR we have discovered another pathway...they have discovered another pathway! https://communities.springernature.com/posts/dickkopf-1-dkk1-drives-growth-and-metastases-in-castration-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
3 months ago
Found a Reliable Place to Buy Enzalutamide Prostate Cancer Medication at Low Price
I found a trustworthy place to purchase Enzalutamide, a medication for prostate cancer, at a fair price. I bought it from Oddway International, an Indian pharmaceutical distributor. They were really helpful and answered all my questions patiently. The medicine arrived on time and at a price I could afford
I found a trustworthy place to purchase Enzalutamide, a medication for prostate cancer, at a fair price. I bought it from Oddway International, an Indian pharmaceutical distributor. They were really helpful and answered all my questions patiently. The medicine arrived on time and at a price I could afford
davidjroberts
in
Fight Prostate Cancer
3 months ago
My up and down PSA levels.
On this journey I have had an up and down PSA level. My first indication was of 107 . With various drugs and 25 sessions of radiation,PSA was down to .075. That was November 23.December 23...PSA 18 Consultant told me my prostate had metastasize in to my lung. PSA rose to 117...started chemo March 23.
On this journey I have had an up and down PSA level. My first indication was of 107 . With various drugs and 25 sessions of radiation,PSA was down to .075. That was November 23.December 23...PSA 18 Consultant told me my prostate had metastasize in to my lung. PSA rose to 117...started chemo March 23.
PDH2024
in
Advanced Prostate Cancer
3 months ago
Pulmonary Complications Post Lutetium-177-PSMA-617 Therapy in Metastatic Castration-Resistant Prostate Cancer #Pluvicto
We present the case of a patient with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) who underwent treatment with lutetium Lu-177 vipivotide tetraxetan (also known as 177Lu-PSMA-617) due to progressive disease despite multiple lines of therapy, including chemotherapy, hormonal
We present the case of a patient with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) who underwent treatment with lutetium Lu-177 vipivotide tetraxetan (also known as 177Lu-PSMA-617) due to progressive disease despite multiple lines of therapy, including chemotherapy, hormonal
God_Loves_Me
in
Advanced Prostate Cancer
4 months ago
stage 4 Gleason 8/9
I lake low volume Metastatic PCA. Found in 4 lymph nodes / couple spots on pelvic bones . I m on 1m mgs Abby 5 mgs Pred, had a shot of Fermigon and start Lupron next week , Radiation starting end of month . let me know if any suggestions other than a positive attitude? Right now I exercise regularly
I lake low volume Metastatic PCA. Found in 4 lymph nodes / couple spots on pelvic bones . I m on 1m mgs Abby 5 mgs Pred, had a shot of Fermigon and start Lupron next week , Radiation starting end of month . let me know if any suggestions other than a positive attitude? Right now I exercise regularly
Pjford
in
Advanced Prostate Cancer
4 months ago
Be Interviewed and Help Everyone with your story
Based on the outstanding response to yesterday's video with Don (the retired Canadian Mountie), I will be happy to record more interviews with the guys in our prostate cancer community. Your experience could help others navigate their paths and provide invaluable insights into the everyday realities
Based on the outstanding response to yesterday's video with Don (the retired Canadian Mountie), I will be happy to record more interviews with the guys in our prostate cancer community. Your experience could help others navigate their paths and provide invaluable insights into the everyday realities
Darryl
Partner
in
Prostate Cancer Network
4 months ago
Case of stage 3 PCa patient that chose plant based diet
Stewart D Rose & Amanda J Strombom, 2020. "Stage 3 Prostate Cancer Treated with a Plant-Based Diet A Case Report," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 15(5), pages 142-143, February. Volume 15 Issue 5 - February 2020 DOI: 10.19080/CTOIJ.2020.15.555922 Abstract
Stewart D Rose & Amanda J Strombom, 2020. "Stage 3 Prostate Cancer Treated with a Plant-Based Diet A Case Report," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 15(5), pages 142-143, February. Volume 15 Issue 5 - February 2020 DOI: 10.19080/CTOIJ.2020.15.555922 Abstract
Graham49
in
Advanced Prostate Cancer
4 months ago
In the UK Olaparib only seems to be available for those testing positive for BRCA. Is this a cost issue that it is not widely available?
Beej59• A few seconds ago•0 Replies My partner has advanced PC with tumours in ribs, spine and iliac. He has been stable on Zoladex for 8 years but this may now be changing. We insisted on a BRCA test which has come back negative but from what I understand Olaparib is only being made available
Beej59• A few seconds ago•0 Replies My partner has advanced PC with tumours in ribs, spine and iliac. He has been stable on Zoladex for 8 years but this may now be changing. We insisted on a BRCA test which has come back negative but from what I understand Olaparib is only being made available
Beej59
in
Prostate Cancer Network
4 months ago
In the UK Olaparib only seems to be available for those testing positive for BRCA. Is this a cost issue that it is not widely available?
My partner has advanced PC with tumours in ribs, spine and iliac. He has been stable on Zoladex for 8 years but this may now be changing. We insisted on a BRCA test which has come back negative but from what I understand Olaparib is only being made available to patients in the UK for those who test
My partner has advanced PC with tumours in ribs, spine and iliac. He has been stable on Zoladex for 8 years but this may now be changing. We insisted on a BRCA test which has come back negative but from what I understand Olaparib is only being made available to patients in the UK for those who test
Beej59
in
Advanced Prostate Cancer
4 months ago
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