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Mitochondrial Protections for Aging Humans PartII
Mitochondrial Antioxidants 1) Coenzyme Q10 -Ubiquinone (CoQ10) Coenzyme Q10 (CoQ10) is considered the "mitochondrial specific antioxidant". It is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All
Mitochondrial Antioxidants 1) Coenzyme Q10 -Ubiquinone (CoQ10) Coenzyme Q10 (CoQ10) is considered the "mitochondrial specific antioxidant". It is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All
MateoBeach
in
Fight Prostate Cancer
2 years ago
Ambroxol and Parkinson’s
a clinical trial of ambroxol called ‘Ambroxol to Slow Progression in Parkinson’, or the ‘ASPro – PD’ trial, will begin. This is a large phase 3 clinical trial to determine if ambroxol can slow or stop Parkinson’s. It is led by Professor Anthony Schapira at University College London and is funded by Cure
a clinical trial of ambroxol called ‘Ambroxol to Slow Progression in Parkinson’, or the ‘ASPro – PD’ trial, will begin. This is a large phase 3 clinical trial to determine if ambroxol can slow or stop Parkinson’s. It is led by Professor Anthony Schapira at University College London and is funded by Cure
Farooqji
in
Cure Parkinson's
2 years ago
Immunocompromised
I’m currently in a clinical trial receiving infusions of a drug similar to rituximab, and therefore immunocompromised. I am a public employee and in a battle with my employer. I was working remotely for 2 years, and my job is easily accomplished remotely. They are now requiring me to come back full
I’m currently in a clinical trial receiving infusions of a drug similar to rituximab, and therefore immunocompromised. I am a public employee and in a battle with my employer. I was working remotely for 2 years, and my job is easily accomplished remotely. They are now requiring me to come back full
MsAmyM
in
Kidney Disease
2 years ago
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Early ablation better at preventing AF progression than drug therapy
https://www.medscape.com/viewarticle/983882?src=wnl_edit_tpal&uac=181644BG&impID=4857392&faf=1"CHICAGO – Early ablation of atrial fibrillation (AFib) reduces the risk of progression, compared with antiarrhythmic therapies, according to results of a multicenter, randomized trial called PROGRESSIVE-AF.
https://www.medscape.com/viewarticle/983882?src=wnl_edit_tpal&uac=181644BG&impID=4857392&faf=1"CHICAGO – Early ablation of atrial fibrillation (AFib) reduces the risk of progression, compared with antiarrhythmic therapies, according to results of a multicenter, randomized trial called PROGRESSIVE-AF.
Bagrat
in
AF Association
2 years ago
BIOVAS clinical trial for Non-ANCA associated vasculitis.
Vasculitis UK is supporting the BIOVAS trial by sharing their project to help them recruit patients. If you are interested, please contact your local team to discuss it.
Vasculitis UK is supporting the BIOVAS trial by sharing their project to help them recruit patients. If you are interested, please contact your local team to discuss it.
zoe69
Vasculitis UK
in
Vasculitis UK
2 years ago
A New Cell Therapy Trial for MF
Not sure if this has come up before. This company is focused on improving SCT for bone cancers with a new agent, Orca-T. https://orcabio.com/clinical-programs/ A phase 2 trial for MF had this result among others: "Regression of marrow fibrosis to MF grade 0 or 1 was noted by D+ 100 in 7 of 7 Orca-T
Not sure if this has come up before. This company is focused on improving SCT for bone cancers with a new agent, Orca-T. https://orcabio.com/clinical-programs/ A phase 2 trial for MF had this result among others: "Regression of marrow fibrosis to MF grade 0 or 1 was noted by D+ 100 in 7 of 7 Orca-T
EPguy
in
MPN Voice
2 years ago
Chemo (Docetaxel) with Prednisone
Hi all, Zytiga stopped working for me and I am castrate-resistant. After a failed clinical trial (immunotherapy) I started Docetaxel 2 weeks ago and was prescribed Prednisone (5mg twice per day). I seem to be very sensitive to the Prednisone....having trouble sleeping, feeling anxious, etc. even when
Hi all, Zytiga stopped working for me and I am castrate-resistant. After a failed clinical trial (immunotherapy) I started Docetaxel 2 weeks ago and was prescribed Prednisone (5mg twice per day). I seem to be very sensitive to the Prednisone....having trouble sleeping, feeling anxious, etc. even when
carguy
in
Advanced Prostate Cancer
2 years ago
11 clinical trials that will shape medicine in 2023
https://www.nature.com/articles/s41591-022-02132-3
https://www.nature.com/articles/s41591-022-02132-3
Farooqji
in
Cure Parkinson's
2 years ago
Modified Citrus Pectin - reply from Dr Eliaz
A member asked me to post the reply I was to get from Dr Isaac Eliaz on MCP, Modified Citrus Pectin / Pectasol and I do this. Below is my communication with dr Eliaz, generously facilitated by AnnieAppleseed, followed by excerpts from two studies. Dr. Eliaz writes that 80 % of patients with BRPC,
A member asked me to post the reply I was to get from Dr Isaac Eliaz on MCP, Modified Citrus Pectin / Pectasol and I do this. Below is my communication with dr Eliaz, generously facilitated by AnnieAppleseed, followed by excerpts from two studies. Dr. Eliaz writes that 80 % of patients with BRPC,
Purple-Bike
in
Advanced Prostate Cancer
2 years ago
Pluvicto increases radiographic progression-free survival (rPFS) before chemo
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
This is the early topline results from the
PSMAfore
trial. https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (abiraterone, enzalutamide, darolutamide
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Doxycycline
Bottom Line: Low-dose Doxycycline may be a useful add-on to other therapies, for a number of reasons: i) inhibition of mitochondrial protein synthesis, with decreased ATP and a slowing of proliferation ... ii) ... &, with a particularly detrimental effect on PCa stem cell-like cells iii) inhibition
Bottom Line: Low-dose Doxycycline may be a useful add-on to other therapies, for a number of reasons: i) inhibition of mitochondrial protein synthesis, with decreased ATP and a slowing of proliferation ... ii) ... &, with a particularly detrimental effect on PCa stem cell-like cells iii) inhibition
pca2004
in
Fight Prostate Cancer
2 years ago
A New Clinical Trial for Pain and Fibrosis in Chronic Pancreatitis!
Hi everyone! I wanted to announce that there's a new clinical trial testing proglumide for pain and fibrosis in chronic pancreatitis patients that is currently recruiting participants in the Washington, D.C. area! We helped design this trial, but we need your help to find participants and get this drug
Hi everyone! I wanted to announce that there's a new clinical trial testing proglumide for pain and fibrosis in chronic pancreatitis patients that is currently recruiting participants in the Washington, D.C. area! We helped design this trial, but we need your help to find participants and get this drug
Skye_MC
Administrator
in
Chronic Pancreatitis Support
2 years ago
Anti-arithmetic meds with Paxil (Paroxetine) - an anxiety med.
Was just wondering if anyone is on or has tried Flecainide or Propafenone while also taking Paxil (Paroxetine)? If so, how did it work out? Side effects or health issues or none at all? Thank you for anyone who cares to reply!
Was just wondering if anyone is on or has tried Flecainide or Propafenone while also taking Paxil (Paroxetine)? If so, how did it work out? Side effects or health issues or none at all? Thank you for anyone who cares to reply!
Jpot34
in
AF Association
2 years ago
Anti-Arithmetic meds while taking Paxil (Paroxetine) - an anxiety med.
Does anyone take Paxil (Paroxetine) with Flecainide or Propafenone? Both these AFIB meds work better for vagal AFIB. Was just wondering if anyone mixed these two drugs, and if it has worked out or not? Thank you for any and all replies!
Does anyone take Paxil (Paroxetine) with Flecainide or Propafenone? Both these AFIB meds work better for vagal AFIB. Was just wondering if anyone mixed these two drugs, and if it has worked out or not? Thank you for any and all replies!
Jpot34
in
Arrhythmia Alliance
2 years ago
Atrial Flutter and AFib
Hello, Briefly I've had multiple Aortic/Mitral valve surgeries, with the second in 2013 I acquired Complete Heart Block, Permanent AF, Shunt, and my Pacemaker. I'm probably lucky that I've been reasonably stable over the years, other than every now and again having the PM settings altered. On Warfarin
Hello, Briefly I've had multiple Aortic/Mitral valve surgeries, with the second in 2013 I acquired Complete Heart Block, Permanent AF, Shunt, and my Pacemaker. I'm probably lucky that I've been reasonably stable over the years, other than every now and again having the PM settings altered. On Warfarin
Hidden
in
AF Association
2 years ago
6 month post mini maze (surgical ablation) in the U.K. All is going well, no regrets
hello you lovely lot. I thought I would give you an update as I have had my 6 month (and final eeeek) review with my mini maze surgeon Mr Hunter this morning. All has been going well, in sinus rythm since my mini maze. I had a two week heart monitor a few weeks ago, all good! I have a low burden
hello you lovely lot. I thought I would give you an update as I have had my 6 month (and final eeeek) review with my mini maze surgeon Mr Hunter this morning. All has been going well, in sinus rythm since my mini maze. I had a two week heart monitor a few weeks ago, all good! I have a low burden
MummyLuv
in
AF Association
2 years ago
kardia
Hi, I had atrial flutter treated successfully by ablation 2 years ago. I still take anti-coagulants and have been told that I could now stop these. I am worried about doing this, so my doctor is suggesting monitoring with a Kardia device for a few months and if all good, then stopping. My question
Hi, I had atrial flutter treated successfully by ablation 2 years ago. I still take anti-coagulants and have been told that I could now stop these. I am worried about doing this, so my doctor is suggesting monitoring with a Kardia device for a few months and if all good, then stopping. My question
Easternmost
in
Arrhythmia Alliance
2 years ago
Persistent Afib
Thank you all for your encouraging replies to my post yesterday. Yes unless I have something wrong with me or I over exercise my heart rate does not go above 100. The only worrying concern is the Kardia readings which consistently show a variation of between 2.5 and 6.5 squares in one reading. If you
Thank you all for your encouraging replies to my post yesterday. Yes unless I have something wrong with me or I over exercise my heart rate does not go above 100. The only worrying concern is the Kardia readings which consistently show a variation of between 2.5 and 6.5 squares in one reading. If you
Swimsyroke
in
AF Association
2 years ago
Update on progress with MF and the FEDORA clinical trial
So to recap, I was diagnosed with primary MF in October 2022 and asked to join a new clinical trial called FEDORA. After many tests including a BMB, ultrasound on my abdomen, chest X-ray etc. I started on the pre medication of 400mg/day (in one dose) of Fedratinib in capsule form. This was the first
So to recap, I was diagnosed with primary MF in October 2022 and asked to join a new clinical trial called FEDORA. After many tests including a BMB, ultrasound on my abdomen, chest X-ray etc. I started on the pre medication of 400mg/day (in one dose) of Fedratinib in capsule form. This was the first
Flyingsteamer
in
MPN Voice
2 years ago
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
[u]
"Future studies should study the effects of long-term supplementation of promising nutrients, such as butyrate and niacin, on their abilities to halt or reverse disease progression in PD. "
[/u] Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson
[u]
"Future studies should study the effects of long-term supplementation of promising nutrients, such as butyrate and niacin, on their abilities to halt or reverse disease progression in PD. "
[/u] Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson
Bolt_Upright
in
Cure Parkinson's
2 years ago
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