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Experiences with
Androgen deprivation therapy (ADT)
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Osteoporosis risk with suppressed TSH
Many of the endocrinologist I've encountered seem to be vexed with borderline sociopathy, lurking beneath grimacing, slightly tolerant demeanors. However, the last one seemed to be merely friendly and inept. Recent communication from current specialist: "Having a low TSH can increase your risk for heart
Many of the endocrinologist I've encountered seem to be vexed with borderline sociopathy, lurking beneath grimacing, slightly tolerant demeanors. However, the last one seemed to be merely friendly and inept. Recent communication from current specialist: "Having a low TSH can increase your risk for heart
RockyPath
in
Thyroid UK
10 months ago
NDT dosing confusion, how to make it work?
Hi All, Trying to understand the NDT dosing and if it's working for me. They say 1 grain of Erfa is about 100 McG of levo. However, 1 grain only gives you 38 McG of T4. So if I was on 88 McG of levo before NDT and I now take 1 grain of NDT instead, I only get 38 McG of T4? How does the 1 grain equals
Hi All, Trying to understand the NDT dosing and if it's working for me. They say 1 grain of Erfa is about 100 McG of levo. However, 1 grain only gives you 38 McG of T4. So if I was on 88 McG of levo before NDT and I now take 1 grain of NDT instead, I only get 38 McG of T4? How does the 1 grain equals
Juliet_22
in
Thyroid UK
10 months ago
Am I a poor converter?
I've just had my latest blood test results after starting 50mg Levothyroxine 6 weeks ago:TSH 1.65 (0.27-4.2) FT4 15.9 (12-22) 39% through range FT3 3.4 (3.1-6.8) 8% through range FT4:FT3 ratio is therefore 4.7. Just before starting Levothyroxine, my results were: TSH 5.88 FT4 12 FT3 3.44 FT4:FT3
I've just had my latest blood test results after starting 50mg Levothyroxine 6 weeks ago:TSH 1.65 (0.27-4.2) FT4 15.9 (12-22) 39% through range FT3 3.4 (3.1-6.8) 8% through range FT4:FT3 ratio is therefore 4.7. Just before starting Levothyroxine, my results were: TSH 5.88 FT4 12 FT3 3.44 FT4:FT3
Schilddruse
in
Thyroid UK
10 months ago
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Mum with CBD
Good morning It's been a while since I wrote on here. My mum got diagnosed with CBD in 2017 we were told in January 2020 she had 4 weeks left to live and was moved into a care home for palliative care. Thankfully she is still with us. Hasn't eaten and been bed bound now for 4 years. She survives on 6
Good morning It's been a while since I wrote on here. My mum got diagnosed with CBD in 2017 we were told in January 2020 she had 4 weeks left to live and was moved into a care home for palliative care. Thankfully she is still with us. Hasn't eaten and been bed bound now for 4 years. She survives on 6
Bobbiejo21
in
PSP Association
8 months ago
EXTEND - Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer
The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase II Trial were published in JAMA Oncology this month [1]. {However, many will have seen the results, as presented at ASTRO 2022, & posted by Fish, 6 months ago [2].}
Results
"The study included
The results of the EXTEND [EXTernal beam radiation to Eliminate Nominal metastatic Disease] Phase II Trial were published in JAMA Oncology this month [1]. {However, many will have seen the results, as presented at ASTRO 2022, & posted by Fish, 6 months ago [2].}
Results
"The study included
pjoshea13
in
Fight Prostate Cancer
1 year ago
Rezvilutamide: new anti-androgen is better than Casodex added to ADT for newly diagnosed high-met HSPC. But is field too crowded?
They randomized patients with 4 or more bone metastases to Rezvilutamide+
ADT
or Casodex+
ADT
. It increased 2-year radiographic progression-free survival by 56% and 2-year overall survival by 42%. It also significantly increased time to castration resistance by 79%.
They randomized patients with 4 or more bone metastases to Rezvilutamide+
ADT
or Casodex+
ADT
. It increased 2-year radiographic progression-free survival by 56% and 2-year overall survival by 42%. It also significantly increased time to castration resistance by 79%.
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Starting Lupron ... Again
After a couple of delays I finally had the appointment with my MO regarding re-starting
ADT
. To review, I've been on a year long
ADT
vacation, my second vacation. This vacation was approximately 18 months after completing RT.
After a couple of delays I finally had the appointment with my MO regarding re-starting
ADT
. To review, I've been on a year long
ADT
vacation, my second vacation. This vacation was approximately 18 months after completing RT.
fireandice123
in
Advanced Prostate Cancer
2 years ago
Converting NDT and T3 to combo
I am currently on 20 mcg T3 and 150 mcg Thyroid—S daily. I have always bought my own medication as I didn't think I would manage to get T3 on NHS. I have just received a message to say they will give it to me so I'm over the moon. They also want me to ditch the Thyroid-S and replace with 100mcg Levo.
I am currently on 20 mcg T3 and 150 mcg Thyroid—S daily. I have always bought my own medication as I didn't think I would manage to get T3 on NHS. I have just received a message to say they will give it to me so I'm over the moon. They also want me to ditch the Thyroid-S and replace with 100mcg Levo.
carolinegodlonton
in
Thyroid UK
10 months ago
Plain English for a layman please!
He has Gleason 5 + 5 disease and regional disease by NCCN classification I'm currently in my 4th month of
ADT
(3-month Eligard injections and 1000mg/d abiraterone), initially planned to last 2 years. I'm set to start proton therapy around 2/1/23.
He has Gleason 5 + 5 disease and regional disease by NCCN classification I'm currently in my 4th month of
ADT
(3-month Eligard injections and 1000mg/d abiraterone), initially planned to last 2 years. I'm set to start proton therapy around 2/1/23.
Atdabeach
in
Advanced Prostate Cancer
1 year ago
one final chance of survival
hi, Yesterday I posted an update about my mum and her icu journey. I have a further update I would like to share. From her ct the original infection is finally clearing up. She has a lot of fluid around her lungs and pneumonia at the bottom that the antibiotics are not clearing. They said the chance
hi, Yesterday I posted an update about my mum and her icu journey. I have a further update I would like to share. From her ct the original infection is finally clearing up. She has a lot of fluid around her lungs and pneumonia at the bottom that the antibiotics are not clearing. They said the chance
Westbeginners1
in
ICUsteps
8 months ago
High TSH on high NDT dose
Hey, I'm feeling so confused. Any advice appreciated! I have used Thyrogold (NDT) to successfully treat my underactive thyroid (Hypothyroid with Hashimotos) for the last few years. Occasionally my dose needs altering slightly but generally it has remained stable on this medication. I am currently taking
Hey, I'm feeling so confused. Any advice appreciated! I have used Thyrogold (NDT) to successfully treat my underactive thyroid (Hypothyroid with Hashimotos) for the last few years. Occasionally my dose needs altering slightly but generally it has remained stable on this medication. I am currently taking
SunshineSaff
in
Thyroid UK
10 months ago
Frustrated at endo's obsession with TSH when other results point in the opposite direction
I hope this isn't going to take too long to explain. And this is really a frustrated rant about the obsession with TSH. I went to see a private endo, as my hypo symptoms had not resolved on a daily dose of 150mcg T4 and a split dose of 40mcg T3, given to me by an NHS endo who was prepared to accept
I hope this isn't going to take too long to explain. And this is really a frustrated rant about the obsession with TSH. I went to see a private endo, as my hypo symptoms had not resolved on a daily dose of 150mcg T4 and a split dose of 40mcg T3, given to me by an NHS endo who was prepared to accept
Reefseeker
in
Thyroid UK
10 months ago
High cortisol
Hello again, So I finally did a 4 point saliva cortisol test and morning cortisol is high , how do I lowe this ? Could this be why im not tolerating my t3 in the ndt ?
Hello again, So I finally did a 4 point saliva cortisol test and morning cortisol is high , how do I lowe this ? Could this be why im not tolerating my t3 in the ndt ?
Rhannii7
in
Thyroid UK
10 months ago
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
University Hospital Virgen del Rocío, 41013 Seville, Spain.PMID: 37189723 DOI: 10.3390/biomedicines11041105
Abstract
Since prostate cancer (PCa) was described as androgen-dependent, the androgen receptor (AR) has become the mainstay of its systemic treatment: androgen deprivation therapy (
ADT
University Hospital Virgen del Rocío, 41013 Seville, Spain.PMID: 37189723 DOI: 10.3390/biomedicines11041105
Abstract
Since prostate cancer (PCa) was described as androgen-dependent, the androgen receptor (AR) has become the mainstay of its systemic treatment: androgen deprivation therapy (
ADT
pca2004
in
Fight Prostate Cancer
1 year ago
Update after 6 months on SARMS Osterine and Carderine along with ADT
I said I would keep my experiment n=1 with SARMS updated for any fellow warriors. PSA still undetectable: 12/7/2022 PSA <0.1 all liver numbers normal. Briefly: RP 2015, then 37 treatments of EBRT after PSA started rising shortly after. Bio recurrence 2019. May-25-2022 TEST RESULTS: PSA 15.2, T
I said I would keep my experiment n=1 with SARMS updated for any fellow warriors. PSA still undetectable: 12/7/2022 PSA <0.1 all liver numbers normal. Briefly: RP 2015, then 37 treatments of EBRT after PSA started rising shortly after. Bio recurrence 2019. May-25-2022 TEST RESULTS: PSA 15.2, T
KocoPr
in
Advanced Prostate Cancer
2 years ago
Is this a "normal" reaction to NDT?
Hi All, I'm trying to take NDT instead of levo, on which I was for around 20 years before, mostly on 75 mcg. My TSH went out of balance back in October 2022 and between then and now it's been a massive struggle. I increase my T4 slightly (even by 12,5 mcg) and get heart palpitations (heart was checked
Hi All, I'm trying to take NDT instead of levo, on which I was for around 20 years before, mostly on 75 mcg. My TSH went out of balance back in October 2022 and between then and now it's been a massive struggle. I increase my T4 slightly (even by 12,5 mcg) and get heart palpitations (heart was checked
Juliet_22
in
Thyroid UK
10 months ago
test results
morning to all , I was just wondering about what I see on my test result My TSH apart from when I have, on a few occasions, reduced hormone treatment runs the same at 0.02 . With little change . Looking at my T4 it changes massively with from 20 sometimes 14 but looks like a see saw . Range
morning to all , I was just wondering about what I see on my test result My TSH apart from when I have, on a few occasions, reduced hormone treatment runs the same at 0.02 . With little change . Looking at my T4 it changes massively with from 20 sometimes 14 but looks like a see saw . Range
Gcart
in
Thyroid UK
1 year ago
Zannado
I was told by endo I could get t3 if I did 6 weeks on levo to show I don't convert properly. I did this on 175 levo but my t4 was rising out of range and t3 not in the highest range. I've been on ndt and t3 but always self sorced. But I was hoping to get t3 on percripton. The gp has said I now have to
I was told by endo I could get t3 if I did 6 weeks on levo to show I don't convert properly. I did this on 175 levo but my t4 was rising out of range and t3 not in the highest range. I've been on ndt and t3 but always self sorced. But I was hoping to get t3 on percripton. The gp has said I now have to
Zannadoo
in
Thyroid UK
10 months ago
serotonin whole blood test level
Is it related to being on
ADT
and the PC? Thanks.
Is it related to being on
ADT
and the PC? Thanks.
Ahk1
in
Advanced Prostate Cancer
2 years ago
Another week of complete agony
I think it is the destruction of muscle and tendon mass caused by
ADT
. My oncology team does not agree. I'm at my whitt's end and am looking for others who may have had this kind of intense pain. I've been on
ADT
for just over two years and never even came close to having this much pain.
I think it is the destruction of muscle and tendon mass caused by
ADT
. My oncology team does not agree. I'm at my whitt's end and am looking for others who may have had this kind of intense pain. I've been on
ADT
for just over two years and never even came close to having this much pain.
bglendi53
in
Advanced Prostate Cancer
2 years ago
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